Blood
Articles in this Issue
Diagnosis and prediction of precursor states in multiple myeloma using cell-free chromatin
Abstract Multiple myeloma (MM) is a hematological malignancy that, in many cases, is preceded by monoclonal gammopathy of undetermined signi...
Phosphatidylcholine synthesis inhibition diminishes ASXL1 and DNMT3a mutation driven clonal hematopoiesis
Abstract The acquisition of somatic mutations that increase the competitive potential of hematopoietic stem and progenitor cell (HSPC) clone...
Clinical outcomes up to 4 years of once-weekly efanesoctocog alfa prophylaxis in previously treated adults, adolescents, and children with severe hemophilia A: Interim analysis of the Phase 3 XTEND-ed long-term extension study
Abstract Introduction Efanesoctocog alfa is a first-in-class high-sustained factor VIII (FVIII) replacement therapy designed to decouple rec...
Paquinimod regulate megakaryocyte function by restoring mitochondrial oxidative phosphorylation in acute myeloid leukemia
Abstract Introduction A malignant inflammatory microenvironment exists in acute myeloid leukemia (AML), and many inflammatory molecules affe...
A novel VWF mutation associated with macrothrombocytopenia, cytoskeletal defects, and distinct functional abnormalities: A case report
Abstract Background: von Willebrand disease type 2B (vWD 2B) is a rare inherited bleeding disorder characterized by gain-of-function mutatio...
An interactive database containing all known variants in ADAMTS13 yields new insight into the genetic variation and protein changes underlying congenital TTP
Abstract Introduction A disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13 (ADAMTS13) is encoded by a 45kb gene o...
Disparities in venous thromboembolism management in patients with sickle cell disease: A nationwide inpatient sample study
Abstract Background: Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), is a substantial b...
Glofitamab combined with salvage therapy for relapsed or refractory aggressive B-cell lymphomas: Efficacy and safety in a real-world prospective observational study
Abstract Background: Glofitamab, a CD20×CD3 bispecific antibody, has shown remarkable efficacy in relapsed or refractory (R/R) aggressive B-...
β‑hydroxybutyrate metabolism enhances CAR T cell function via transcriptional and epigenetic reprogramming
Abstract Introduction. The impact of patient (pt) lifestyle, particularly diet, on chimeric antigen receptor (CAR) T cell therapy remains po...
Healthcare Providers' knowledge and attitudes toward venous thromboembolism prophylaxis in multiple myeloma: A cross-sectional survey
Abstract Background: Venous thromboembolism (VTE) remains a major complication in multiple myeloma (MM), despite the recommended predictive...
Feasibility and impact of rapid newborn screening for sickle cell disease in Tanzania: Results from the tabora region pilot program (SickleCare)
Abstract Background: Tanzania bears a substantial burden of sickle cell disease (SCD), with an estimated 11,000 affected...
Indole-related metabolites suppress the anti-tumor function of CD8+ T cells in the bone marrow microenvironment of multiple myeloma
Abstract Multiple myeloma (MM), the second most common hematologic malignancy, presents significant clinical challenges due to its relapsing...
CRISPR-ko screen identifies RARα inhibition as a strategy to increase CD38 expression in multiple myeloma and potentiate anti-CD38 therapy.
Abstract The monoclonal antibody (mAb) Daratumumab (Dara) targets CD38 to trigger cytotoxicity against myeloma cells. Dara achieves good res...
HIT or miss?: Long-term outcomes of direct thrombin inhibitors vs fondaparinux use in heparin-induced thrombocytopenia
Abstract Background: Heparin-induced thrombocytopenia (HIT) is a rare but serious immune-mediated complication of heparin therapy characteriz...
A novel random survival forest model for adult NPM1-mutated Acute Myeloid Leukemia patients
Abstract Background: NPM1-mutated acute myeloid leukemia (AML) is the most common molecular subtype in adult AML, comprising 30-35% of cases...
Curcumin and resveratrol sensitizes TP53 mutant acute myeloid leukemia (AML) cell lines to venetoclax-induced apoptosis
Abstract While venetoclax-based regimens have significantly improved outcomes for many patients with acute myeloid leukemia (AML), those wit...
Heme-regulated eIF2α (HRI) is required during iron restriction to alleviate ß-thalassemia via mTORC1 inhibition, autophagy activation, and suppression of protein synthesis, contributing to clearance of toxic free α-globin
Abstract In β-thalassemia, hepcidin deficiency and chronic red blood cell (RBC) transfusions cause iron overload leading to multi-organ dama...
*pediatric transplant data from a center in a remote area in interior sindh, Pakistan*
Abstract Background: The Gambat Institute of Medical Sciences (GIMS), located in a remote region of interior Sindh, is only public-sector fa...
A randomized, multicenter trial of shorter durations of hypomethylating agents in lower-risk Myelodysplastic Syndromes
Abstract Background In higher-risk myelodysplastic syndromes (MDS), the standard doses of hypomethylating agents are azacitidine 75 mg/m2 fo...
CTD402: Allogeneic CAR-t manufacturing that overcomes donor- & process-derived variation with robust clinical activity
Abstract Background: Allogeneic CAR-T cell therapies offer key advantages over autologous approaches, including simplified manufacturing log...
Treatment funding source and educational level are important prognostic factors for patients with diffuse large B-cell lymphoma in the state of São paulo, Brazil: Analysis of a large real-world data.
Abstract Introduction: Diffuse large B-cell lymphoma (DLBCL) is among the ten most prevalent cancers in Brazil. Although the country has num...
Novel von willebrand factor targeting thrombolytic TGD001 is safe and well tolerated in a phase 1 first-in-human trial
Abstract Introduction TGD001 is a novel thrombolytic fusion protein that binds with high affinity to von Willebrand factor (VWF) for targete...
Impact of sequencing of CART vs bi-specific antibody on survival in relapsed/refractory large B-cell lymphoma: An analysis from the ABC consortium
Abstract Background: CART and bispecific antibodies (BsAb) are both effective treatments for patients (pts) with relapse...
The m5C-binding protein YB-1 modulates proteasome inhibitors resistance in multiple myeloma via epigenetic modification
Abstract Multiple myeloma (MM) is a malignant proliferative disorder of plasma cells, and resistance to proteasome inhibitors (PIs) represen...
Imaging flow cytometry for detection of red blood cell inclusions: A quantitative approach to assess splenic filtration function in sickle cell disease
Abstract Introduction. The spleen plays a critical role in maintaining red blood cell (RBC) homeostasis by removing intracellular inclusions...