Blood
Articles in this Issue
Low-dose teclistamab in newly diagnosed multiple myeloma patients
Abstract Background: Teclistamab is a bispecific antibody targeting B-cell maturation antigen (BCMA), which has shown efficacy in the achieve...
Real-world characteristics and outcomes of newly diagnosed multiple myeloma patients receiving autologous stem cell transplantation (2018–2024) from the honeur network
Abstract Introduction Eligibility for autologous stem cell transplantation (ASCT) in multiple myeloma clinical trials is primarily determine...
Increased prevalence and severity of cardiac iron overload in transfusion dependent diamond-blackfan anemia syndrome caused by small versus large ribosomal subunit mutations
Abstract Background and Aims Diamond-Blackfan anemia syndrome (DBAS) is an inherited bone marrow failure syndrome characterized by erythroid...
Using a medically trained LLM-based end-to-end system in automating patient eligibility screening across a health system for A phase 3 study evaluating the safety of givinostat in patients with polycythemia vera.
Abstract Background: The process of assessing and identifying eligible participants for clinical trials is lengthy, and resource-intensive,...
Integrating the cardiovascular-renal-metabolic syndrome（ckm）: Construction and validation of a comprehensive model for early identification of high-risk multiple myeloma
Abstract BackgroundHigh-risk multiple myeloma (HRMM) is a subtype that accounts for approximately 15-20% of MM patients and is characterized...
Comparison of outcomes with different approaches to antithrombotic therapy after venous stenting
Abstract Purpose: Venous obstruction can occur as a result of deep vein thrombosis (DVT), anatomic abnormalities like Ma...
Exploring the anti-AML mechanisms of compound zhebei granule via integrated network pharmacology, transcriptomic sequencing, and experimental validation
Abstract Background: Acute myeloid leukemia (AML) is a hematologic malignancy with a poor prognosis. In recent years, the clinical applicati...
Frequency and impact of FLT3-ITD microclones in younger AML patients
Abstract Introduction: FLT3 internal tandem duplications (ITD) are found in approximately 25% AML and defined by an allelic ratio (AR)≥0.05,...
Prognostic evaluation of ELN-2022 and ELN-2024 risk stratification in newly diagnosed AML patients and development of a novel genetic risk model
Abstract Background: The pathogenesis of acute myeloid leukemia (AML) is complex, with cytogenetic and molecular abnormalities currently reg...
Direct measurement is required for accurate assessment of body composition during therapy for acute lymphoblastic leukemia: A report from the T2020-003 IDEAL2 trial
Abstract Background: Obesity adversely impacts disease response and survival for children, adolescents, and adults with acute lymphoblastic...
BTK inhibitor (Bruton Tyrosine Kinase inhibitor) plus anti-CD20 antibody therapy surpasses CIT( chemoimmunotherapy)in frontline CLL( chronic lymphocytic leukemia) with obinutuzumab drives deeper remissions: A meta‑analysis of randomized controlled trials
Abstract Introduction Bruton Tyrosine Kinase inhibitors (BTKi) combined with anti-CD20 monoclonal antibodies have emerged as chemotherapy-fr...
Hematopoietic cell transplantation in acute lymphoplastic leukemia: The Mexican experience
Abstract INTRODUCTION Allogeneic hematopoietic cell transplantation (HCT) is an effective therapy for high-risk and relapsed/refractory acute...
Diagnostic evolution in systemic mastocytosis: Clinical impact of who 2022 criteria on smoldering systemic mastocytosis identification in pioneer
Abstract Background: Systemic mastocytosis (SM) is a hematologic neoplasm that includes advanced and non-advanced subtypes. The latter inclu...
Total marrow irradiation-based, intensified reduced-intensity conditioning regimen for hematopoietic cell transplantation in patients aged 60 years or older: A prospective study
Abstract Introduction Although non-myeloablative conditioning regimens are an established option for elderly patients un...
Efficacy and safety of Golidocitinib-based first line regimen in peripheral T-cell lymphoma: A multicenter retrospective study
Abstract Background Peripheral T-cell lymphoma (PTCL) represents a heterogeneous and aggressive non-Hodgkin lymphoma associated with poor cl...
Time burden of treatment with parenteral hypomethylating agents in combination with venetoclax among patients with newly diagnosed Acute Myeloid Leukemia
Abstract INTRODUCTION: Standard of care for patients with newly diagnosed acute myeloid leukemia (AML) who are not eligible for intensive ch...
Rituximab dosing to prevent clinical relapse in immune thrombotic thrombocytopaenic purpura.
Abstract Introduction Pre-emptive rituximab (RTX) is used to treat ADAMTS13 relapse in immune TTP (iTTP) and prevent clinical relapse but th...
Upregulation of BCMA expression by selinexor
Abstract Introduction Selinexor is a first-in-class, selective inhibitor of nuclear export that targets exportin 1 (XPO1), a key nuclear exp...
Trial in progress: A Phase IIb randomized clinical trial combining oral azacitidine and vididencel, a novel immunotherapy, for post-remission / maintenance therapy for adult patients with cytogenetically intermediate and high-risk Acute Myeloid Leukemia (ALLG AMLM22/D4 CADENCE)
Abstract Despite achieving remission, patients with AML have a substantial risk of relapse, particularly if adverse molecular risk, elderly...
Toxicity, efficacy, and clinical management of bispecific antibodies in routine clinical practice: A real-world geltamo study in B-cell lymphoma
Abstract Background: CD20/CD3 bispecific antibodies (BsAbs) have reshaped the treatment of relapsed/refractory large B-cell lymphoma (LBCL)...
Survey on fertility management and outcomes after cellular therapies, on behalf of the EBMT cellular therapy and immunobiology working party
Abstract Chimeric antigen receptor (CAR) T-cell therapy has demonstrated remarkable efficacy in the treatment of B-cell and plasma cell hema...
A branched chain amino acid rheostat controls hematopoietic stem cell replicative lifespan
Abstract Hematopoietic stem cells (HSCs) self-renew and give rise to all mature blood cells upon activation. However, studies using the hist...
A predictive model based on NCCN-IPI and 2 pirnas for prognostic risk stratification of diffuse large B-cell lymphoma (DLBCL)
Abstract Background: This study investigates the prognostic value of abnormally expressed piRNAs in DLBCL and establishes a more accurate pro...
Comparison of paired bone marrow and peripheral blood measurable residual disease in pediatric acute lymphoblastic leukemia by next-generation sequencing: A report from the dana farber ALL consortium protocol 16-001.
Abstract Introduction: Current protocols treating acute lymphoblastic leukemia (ALL) in children, adolescents, and young adults utilize bone...
Impact of continuous lenalidomide on second primary malignancies in patients with multiple myeloma
Abstract Background Approved in 2017, lenalidomide quickly became a cornerstone for maintenance therapy of multiple myeloma (MM). However, e...