Blood
Articles in this Issue
Plasma cell leukemia: A single institution review of cases
Abstract Introduction: Plasma cell leukemia (PCL) is an aggressive variant of multiple myeloma (MM) characterized by circulating plasma cell...
Tumor mutational burden as a novel biomarker of resistance to CD19 CAR-T cell therapy in large B-cell lymphoma
Abstract Background: Relapse and progression of disease (POD) remain the leading causes of treatment failure after CD19-directed chimeric an...
Heterogeneity of circulating CD57+ cytotoxic cell subsets across disease stage and aggressiveness in cutaneous T cell lymphoma
Abstract Background: CD57 is a terminal differentiation marker expressed on subsets of T- and NK cells with high cytotoxic potential, and its...
Real-world outcomes of transplant-ineligible newly diagnosed multiple myeloma patients treated in the United States with contemporary regimens
Abstract Background Outcomes for patients (pts) with transplant-ineligible newly diagnosed multiple myeloma (TI-NDMM) have improved with the...
Title: Hacs1 is a myeloma immunosuppressor driving pro-tumorigenic myelopoiesis and myeloid cell differentiation through MS4A3/IL3/GM-CSF signaling
Abstract Introduction: The bone marrow (BM) microenvironment supports survival of the malignant multiple myeloma (MM) cells and is composed...
Vancomycin-resistant enterococci (VRE) colonization is associated with worse outcomes post allogenic hemopoietic stem cell transplantation
Abstract Background Intestinal colonization with vancomycin-resistant enterococci (VRE) is associated with gut microbiom...
Impact of protein-energy malnutrition on in-hospital outcomes in patients undergoing bone marrow transplantation: Insights from a national inpatient sample
Abstract Background: Protein-energy malnutrition (PEM) is a known contributor to adverse clinical outcomes, particularly in immunocompromise...
Tissue factor pathway inhibitor-reduced and antithrombin-reduced hemophilia state exhibit different coagulation responses to bypassing agents
Abstract Background : Non-factor therapies have been developed to overcome the limitations of conventional treatments in people with hemophi...
Rapid bone marrow blast reduction-guided selinexor-based regimen therapy in relapsed/refractory and newly diagnosed acute myeloid leukemia
Abstract Background:Therapeutic options for relapsed/refractory acute myeloid leukemia (R/R AML) remain limited, with poor long-term surviva...
Quantitative measures of imcd lymph nodes reveal distinguishing characteristics of imcd lymph nodes and clinical subtypes
Abstract Background: Idiopathic multicentric Castleman disease (iMCD) is a rare and complex disorder involving multicentric lymphadenopathy,...
Memory NKG2C+ NK cells develop from NKG2C+ transitional precursors and persist within secondary lymphoid organs
Abstract Background: Natural Killer (NK) cells are critical components of the innate immune system, providing rapid responses against virall...
Anti-CD3/CD20 bispecific antibodies as salvage therapy after CAR-T failure in Relapsed/Refractory large B-cell lymphoma: A systematic review and meta-analysis
Abstract Background Patients with relapsed or refractory (R/R) large B-cell lymphoma (LBCL) who progress after chimeric antigen receptor T-c...
Durability of complete response outperforms complete response rates as a surrogate endpoint for advancing to phase III trials in high-risk myelodysplastic syndromes
Abstract Introduction: Hypomethylating agents (HMAs) remain the only approved standard-of-care therapy shown to improve overall survival (OS...
Electrocardiographic abnormalities and QTc prolongation in sickle cell disease: Insights from the CSSCD cardiac ancillary Study
Abstract Objective: Sickle cell disease (SCD) is associated with multiple cardiovascular complications, including QTc interval prolongation—...
Outcomes of T-cell/histocyte-rich large B-cell lymphoma (THRLBCL): An international LEO/MER and NiHiL collaborative study
Abstract Introduction: THRLBCL is a rare disease accounting for less than 10% of all diffuse large B-cell lymphoma (DLBCL) subtypes. THRLBCL...
Does stroke or silent infarct affect quality of life in adults with sickle cell disease?: A multi-centre study
Abstract Introduction: Stroke is a devastating complication of sickle cell disorders (SCD) causing major morbidity and mortality. Few data e...
Efficacy and safety of lisocabtagene maraleucel monotherapy in relapsed or refractory large B-cell lymphoma: A systematic review and meta-analysis of clinical trials and real-world studies
Abstract Background: Relapsed or refractory (R/R) large B-cell lymphoma (LBCL) has historically been associated with limited responses to th...
The features of FLT3 internal tandem duplication (ITD) in acute myeloid leukemia (AML) patients and impact on prognosis
Abstract Introduction The presence of FMS-like tyrosine kinase 3 internal tandem duplications (FLT3-ITD) in patients wit...
Selinexor, mezigdomide, and dexamethasone in patients with Relapsed/Refractory multiple myeloma who relapsed or are ineligible for T-cell–redirecting therapy: Stomp Phase 1 results
Abstract Introduction CAR T and bispecific antibody treatment for relapsed/refractory multiple myeloma (RRMM) show promising clinical activit...
Trials in progress - a Phase II study of pirtobrutinib in combination with rituximab in untreated marginal zone lymphoma (PIONEER-MZL)
Abstract Background: Marginal zone lymphoma (MZL) is the third most common B-cell lymphoma and accounts for ~7% of all newly diagnosed non-Ho...
Venetoclax in combination with cytarabine with or without idarubicin in children with relapsed or refractory acute myeloid leukemia: A multi-center phase II expansion study
Abstract Background: The prognosis for pediatric patients with relapsed or refractory acute myeloid leukemia (AML) remains poor, with 5-year...
Venetoclax with hypomethylating agents versus intensive chemotherapy as induction therapy in patients with newly diagnosed acute monocytic leukemia
Abstract Introduction Acute monocytic leukemia (AML-M5), a subtype of AML with poor prognosis, has traditionally been treated with intensive...
Impact of molecular profile and variant allele frequency in patients with Acute Myeloid Leukemia undergoing allogeneic transplantation in first remission: A study by the pethema group
Abstract Background: Prognosis and relapse risk in acute myeloid leukemia (AML) depend on factors like age, comorbidities, and notably cytog...
Chronic obstructive pulmonary disease and prior pneumonia as predictors of infectious risk in chronic lymphocytic leukemia patients receiving acalabrutinib or zanubrutinib: A seifem multicentre Study.
Abstract Infections remain a major cause of morbidity and mortality in patients with Chronic Lymphocytic Leukemia (CLL). Although the advent...
T-cell clones of uncertain significance are prevalent in cutaneous T-cell lymphomas
Abstract Background: T-cell receptor (TCR) sequencing is increasingly incorporated into the diagnosis and monitoring of T-cell lymphomas, in...