Blood
Articles in this Issue
Phased variant circulating tumor DNA (ctDNA) tracking provides limited additional power in predicting progressive disease compared with duplex variant tracking in patients with Relapsed/Refractory (R/R) B-cell non-Hodgkin lymphoma (B-NHL) treated with odronextamab
Abstract Introduction Odronextamab, a CD20×CD3 bispecific antibody, showed compelling efficacy and generally manageable safety in patients (...
High efficacy of blinatumomab combined with pembrolizumab in patients with relapsed/refractory (r/r) B cell acute lymphoblastic leukemia (B-ALL): primary analysis of a Phase 1/2 study
Abstract Blinatumomab (blina), a bispecific anti-CD19/CD3 T cell engaging antibody (Ab), provides improved outcomes in patients (pts) with r...
First miniaturized electrophoresis diagnostic platform in USA for hemoglobinopathies : From diagnosis to therapeutic monitoring in real time.
Abstract Hemoglobinopathies, including sickle cell disease (SCD) and thalassemia's, are the most common monogenic diseases globally, affecti...
Loss of the Y chromosome drives context-dependent transcriptional reprogramming in myeloid progenitors and AML1-ETO acute myeloid leukemia (AML)
Abstract Mosaic loss of chromosome Y (LOY) is a highly prevalent somatic event in many cancers (~30% of male tumors) and is frequently obser...
Preclinical feasibility analysis for Phase I study using adoptive iNKT cell transfer to prevent GVHD
Abstract Background. Graft versus host disease (GVHD) remains a leading cause of morbidity and mortality after allogeneic hematopoietic stem...
Interim Results of the CMML intercept study: A prospective observational study to evaluate the role of acute inflammation in CMML disease progression
Abstract Background: Chronic myelomonocytic leukemia (CMML) is a universally fatal adult myeloid neoplasm with a median survival of 32 month...
Quantitative profiling and clinical correlative analysis of fibrocytes and mesenchymal stromal cells in myelofibrosis spleen
Abstract Background: Splenomegaly due to extramedullary hematopoiesis (EMH) is a hallmark of myelofibrosis (MF). Previous studies of splenec...
Differential expression of coagulation and inflammation genes in ITP patients before and after treatment with thrombopoietin receptor agonists
Abstract Introduction Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by low platelet count resulting from immune-medi...
Long-term progression-free survival benefit with ciltacabtagene autoleucel in standard-risk relapsed / refractory multiple myeloma
Abstract Introduction: The CARTITUDE-4 study (NCT04181827), which enrolled patients with lenalidomide-refractory multiple myeloma (MM) after...
Using FXIa-triggered thrombin generation to assess the risk of breakthrough bleeding in patients receiving emicizumab for acquired Hemophilia A
Abstract The treatment of patients with acquired hemophilia A (AHA) is currently changing. Immunosuppressive therapy (IST), the standard of...
Exploiting RAS pathway addiction as a therapeutic vulnerability in myeloid sarcoma
Abstract Myeloid sarcoma is a distinct form of acute myeloid leukemia (AML) which affects approximately 10-15% of patients (pts) with AML. I...
VSA012, a CFB-targeted siRNA, demonstrates a favorable safety profile and sustained efficacy in PNH patients: Interim Analysis from a Phase Ib Study
Abstract Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired hemolytic disorder caused by somatic mutations in the PIG-...
Elevated prevalence of hereditary thrombophilia variants in an endogamous jewish-Mexican cohort
Abstract Background: Hereditary thrombophilias (HTs) are genetic disorders associated with an increased risk of venous thromboembolism (VTE)...
CD43 functions as a CD47 independent “don't eat me” signal and novel immune checkpoint in AML
Abstract CD47 has gained significant attention as a critical anti-phagocytic molecule and therapeutic target for blood cancer immunotherapy....
Heart failure readmissions in patients with iron deficiency anemia: A national readmission database analysis
Abstract Background: Heart Failure is a long-standing enervative that contributes to significant morbidity and mortality...
Enhanced vsvg variants for binder‑dependent and high‑specificity transduction of primary T cells
Abstract Although certain canonical mutation combination of VSVG effectively reduces the affinity between VSVG and LDLR—thereby improving tr...
Low expressed SRSF1 promotes lck exon 8 skipping to attenuate TCR signaling and treg induction in immune thrombocytopenia
Abstract Introduction: Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by platelet destruction and impaired production...
High complete response rates, low dropout rate, and low-grade toxicities in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) receiving GLPG5101, a fresh, early memory-enriched CAR T-cell therapy with a 7-day vein-to-vein time: Results from the ATALANTA-1 DLBCL cohort
Abstract Introduction:CAR T-cell therapies have revolutionized treatment for relapsed/refractory (R/R) DLBCL; however, high rates of progres...
Understanding the burden and predictors of 90-day all-cause readmissions following hospitalization for diffuse large B-cell lymphoma: An analysis of the nationwide readmissions database
Abstract Introduction Diffuse large B-cell lymphoma accounts for one of the highest annual death rates among non-Hodgkin lymphomas, with clo...
Excellent outcomes with anti-PD1 therapy in relapsed/refractory primary mediastinal large B-cell lymphoma: Real-world data from the lysa group
Abstract Background: Relapsed/refractory primary mediastinal large B-cell lymphoma (R/R PMBL) remains a therapeutic challenge, with limited...
Survival outcomes of patients with secondary hemophagocytic lymphohistiocytosis at two academic medical centers in the United States
Abstract Introduction: Secondary hemophagocytic lymphohistiocytosis (sHLH) is a rare, life-threatening hyperinflammatory syndrome characteri...
Outcomes during BTKi treatment for chronic lymphocytic leukemia: Insights from remote therapeutic monitoring
Abstract Introduction Bruton tyrosine kinase inhibitors (BTKis) are an established cornerstone therapy for chronic lymphocytic leukemia/ sma...
Genetic evolution of Waldenström macroglobulinemia across disease stages
Abstract Background: Waldenström Macroglobulinemia (WM) is an indolent B-cell lymphoplasmacytic lymphoma characterized by heterogeneous clini...
A baseline transcriptomic signature predictive of clinical response to menin inhibitors in AML : The PRE-men retrosprospective Study
Abstract Introduction Menin inhbitors (MENi) have been developed mainly in KMT2-r and NPM1cmut aute myeloid leukemia (AML) and showed encoura...
Hematological symptom burden and treatment patterns in patients with IgG4-related disease: A real-world, multicenter retrospective analysis
Abstract Background: IgG4-related disease (IgG4-RD) is a rare, immune-mediated fibroinflammatory condition characterized by tissue infiltrat...