Blood
Articles in this Issue
National temporal trends and demographic disparities in nutritional anemia-relatedmortality in the United States, 1999–2024
Abstract Background: Nutritional anemias remain a preventable cause of morbidity and mortality in the United States, dis...
Contrasting real-world treatment landscapes of bispecific antibodies and CAR-T cells in multiple myeloma and diffuse large B-cell lymphoma
Abstract Introduction: Bispecific antibodies and Chimeric Antigen Receptor (CAR)-T cell therapies are transformative treatments for Multiple...
Folate receptor beta targeting of tumor-associated macrophages improves lymphoma cell responses to CD19 CAR T cells
Abstract Chimeric antigen receptor (CAR) T cell therapies have revolutionized the treatment of patients with relapsed and refractory (R/R) d...
Single-center experience with mitoxantrone hydrochloride liposome-based therapy for patients with myeloid sarcoma
Abstract Background: Myeloid sarcoma (MS) accounts for 3% to 8% of acute myeloid leukemia (AML) cases and is characterized by an extramedulla...
Validation of the artificial intelligence prediction of acute leukemia tool in a Latin American retrospective cohort
Abstract Introduction: Early and accurate identification of acute leukemia (AL) subtypes—acute lymphoblastic leukemia (ALL), acute myeloid l...
Ivosidenib with or without hypomethylating agent in IDH1-mutated AML: Real-world evidence to inform frontline therapy
Abstract Introduction IDH1-mutated (mIDH1) acute myeloid leukemia (AML) is defined by D-2 hydroxyglutarate-driven epigenetic disruption and...
Comparative analysis between inhibitor screen and mini bethesda assay to diagnose low titre inhibitors in hemophilia patients - an experience from a hemophilia comprehensive care center in India
Abstract Introduction : The most common treatment-associated complication in patients with Hemophilia A is the development of inhibitors. In...
Immune population dynamics predict multiple myeloma progression while on daratumumab maintenance therapy following autologous stem cell transplant
Abstract Introduction: Daratumumab, a CD38-targeted monoclonal antibody, is a highly effective therapy in multiple myeloma. Beyond its anti-...
The SCOPE trial: A phase 2 Study of selinexor in combination with pomalidomide and dexamethasone for patients with relapsed and/or refractory multiple myeloma
Abstract Background Multiple myeloma, the second most common hematologic malignancy, has witnessed incremental progress in its management ov...
A phase 2, open-label study of the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of DISC-3405 in participants with polycythemia vera (PV)
Abstract Background and Significance: Polycythemia vera (PV) is a myeloproliferative neoplasm associated with pathologic...
Phase I trial of ruxolitinib plus fostamatinib for the treatment of steroid refractory chronic graft versus host disease
Abstract Background and Significance: Current therapies for steroid-refractory chronic graft versus host disease (SR-cGVHD) feature limited...
Code red (Código Rojo): Multimodal generative AI for specialized hematology education
Abstract Introduction Recent advances in artificial intelligence—particularly in Natural Language Processing via Large Language Models (LLMs...
Trends and disparities in anemia and pneumonia-related mortality in the United States from 1999 to 2023: A CDC wonder database analysis
Abstract Introduction: Anemia and pneumonia are prevalent and often coexisting conditions that contribute significantly to morbidity and mor...
Negative feedback regulation of nfkb, MAPK, and JAK-STAT drives adaptive resistance to gilteritinib in AML
Abstract Kinase activating mutations in the FMS like tyrosine kinase 3 (FLT3) gene represent the most frequent molecular lesion in acute mye...
Efficacy and safety of a retreatment with inotuzumab ozogamicin in adult patients with relapsed/refractory acute lymphoblastic leukemia: A Campus ALL study
Abstract Introduction Inotuzumab ozogamicin (Ino) is an anti-CD22 immuno-conjugated monoclonal antibody, which has impro...
Circadian rhythm disruption impairs CAR-T cell efficacy by promoting an immunosuppressive tumor microenvironment through enhancing monocyte-MDSC infiltration
Abstract Background: Circadian rhythm disruption is associated with various chronic diseases and cancers, and may influence cancer immunothe...
Reprogramming CAR-NK cells with IL-7/IL-7Rα to amplify STAT1 signaling and activate bystander T cells for enhanced immunotherapy
Abstract Chimeric antigen receptor (CAR)-T and CAR-NK cell therapies have shown promise in cancer treatment, but their effectiveness remains...
Pharmacologic activators of immunoproteasomes unmask actionable public and private neoantigens in multiple myeloma patients
Abstract Immunotherapy has emerged as a powerful tool for myeloma-directed cytotoxicity with the unique potential to induce immune memory an...
Multiparametric integration improves diagnostic categorisation of mature, non-CLL B-cell leukemias including atypical CLL - results from the prospective enable-NGS study
Abstract Introduction Enhanced diagnostic categorisation improves patient access to information, novel therapies and clinical trials. We pre...
Lactylation-related LGALS1 promotes immunosuppressive tumor microenvironment and venetoclax resistance in Acute Myeloid Leukemia
Abstract Acute myeloid leukemia (AML) is a highly heterogeneous and immunosuppressive hematologic malignancy. Novel therapies like venetocla...
Evaluation of factors from established prognostic models in patients with chronic lymphocytic leukemia (CLL) treated with zanubrutinib: A post-hoc analysis of two phase 3 studies (SEQUOIA and ALPINE)
Abstract Background: The CLL-International Prognostic Index (IPI) is a weighted scoring system that combines 5 factors (age, clinical stage,...
Adrenal insufficiency in sickle cell disease: A Case series of a potentially underrecognized complication
Abstract Introduction: Endocrinopathies, including adrenal insufficiency (AI), are recognized complications that can occur in sickle cell di...
Treatment patterns and outcomes among warm autoimmune hemolytic anemia patients receiving rituximab in the United States: A retrospective database study
Abstract Background: Rituximab (RTX) is one of the preferred initial treatment options for patients living with warm autoimmune hemolytic an...
Durable efficacy and long-term safety with pelabresib plus ruxolitinib in JAK Inhibitor–Naive myelofibrosis: 96-week Results from the Phase III MANIFEST-2 study
Abstract Janus kinase inhibitor (JAKi) monotherapy, the standard of care for myelofibrosis (MF), improves splenomegaly and symptom burden bu...
NSD2 inhibition suppresses t(4;14) gene expression and oncogenic signaling to impair proliferation in multiple myeloma
Abstract Introduction: The t(4;14) translocation is present in ~12% of Multiple Myeloma (MM) patients and uniformly results in high levels of...