Blood
Articles in this Issue
Clinical characteristics, treatment strategies, and response patterns in evans syndrome: Initial analysis from the spanish resti cohort
Abstract Introduction: Evans syndrome (ES) is a rare, heterogeneous autoimmune disorder characterized by the simultaneous or sequential occu...
Golidocitinib, a selective JAK1 kinase inhibitor, in treatment of late thrombocytopenia after CAR-T cell therapy: Case report
Abstract BackgroundDespite its remarkable success, CAR-T therapy is accompanied by common adverse events, including cytokine release syndrom...
Real-world outcomes with elranatamab in multiple myeloma: A multi-center analysis from the United States multiple myeloma immunotherapy consortium
Abstract Introduction: Elranatamab, a BCMA-CD3 bispecific antibody, has shown efficacy in relapsed multiple myeloma (MM), but real-world dat...
Long-term outcome and risk factors for relapse in pediatric warm autoimmune hemolytic anemia.
Abstract Warm-antibody autoimmune hemolytic anemia (wAIHA) in children is a rare condition with limited data to predict outcomes or optimize...
Optimal dose regimen of epcoritamab in combination with lenalidomide and rituximab in relapsed or refractory follicular lymphoma - analyses of pharmacokinetics and exposure-response relationships of epcore FL-1 Phase 3 study
Abstract Introduction: Epcoritamab is a subcutaneous CD3xCD20 bispecific T-cell engager approved for treating relapsed or refractory (R/R) d...
Development and validation of the predictive aplastic score system (PASS): A simplified tool to diagnose acquired aplastic anemia in adults
Abstract Acquired aplastic anemia (AA) is an immune-mediated bone marrow failure characterized by pancytopenia and a hypocellular marrow, re...
The relationship between neutrophil-to-lymphocyte ratio and mid-term evaluation in patients with gastrointestinal Diffuse large B-cell lymphoma
Abstract Background: Diffuse large B - cell lymphoma (DLBCL) is the most common subtype of non - Hodgkin lymphoma. Approximately 30% - 40% o...
Lactate promotes DLBCL progression via NAT10/ldha axis and immune suppression
Abstract Introduction： Lactate, a metabolic byproduct, can induce protein lactylation that plays a key role in protein stability. However, t...
Non-invasive MDS diagnostic algorithm can also identify pre-MDS and distinguishes normal controls from MDS/pre-MDS patients without bone marrow examination
Abstract Background: Myelodysplastic syndromes (MDS) are often preceded by preMDS states, idiopathic cytopenia of undetermined significance...
Advancing sickle cell disease diagnosis in low-resource settings using Gazelle™, a paper-based microchip electrophoresis platform
Abstract Sickle Cell Disease (SCD), an inherited hemoglobinopathy, disproportionately affects people from the African subcontinent extensive...
Real-world experience with ruxolitinib therapy for steroid-refractory acute graft-versus-host disease following umbilical cord blood transplantation
Abstract Background: Umbilical cord blood transplantation (UCBT) is associated with a slightly lower incidence and sever...
Circulating cell-free BRAFV600E as a biomarker in patients with erdheim-chester disease
Abstract Background and aims: Erdheim-Chester disease (ECD) is a rare, heterogeneous histiocytic disease with recurrent MAPK pathway mutatio...
Motixafortide (CXCR4 inhibition) alone and in combination with natalizumab (VLA-4 inhibition) to mobilize hematopoietic stem cells for gene therapy in sickle cell disease: A first-in-human, safety and feasibility study
Abstract Autologous hematopoietic stem cell (HSC) based gene therapy for sickle cell disease (SCD) requires mobilizing sufficient peripheral...
A unified clinical algorithm for the diagnosis and management of platelet transfusion refractoriness: A systematic synthesis and proposed framework
Abstract Background: Platelet transfusion refractoriness (PTR), or inability to achieve an acceptable rise in platelet c...
Ectopic BCL11B disrupts the activity of early hematopoietic transcription factors to skew lineage commitment
Abstract Enhancer hijacking events that aberrantly activate the T-lineage transcription factor (TF) gene, BCL11B, define a subtype of lineag...
Etiology of anemia in a murine model of myelodysplastic syndrome
Abstract MDS are clonal stem cell disorders characterized by peripheral cytopenias, particularly macrocytic anemia, which is often refractor...
Primary efficacy analysis of phase II study investigating tyrosine kinase inhibitor (TKI) and inotuzumab ozogamicin-based therapy for newly diagnosed Philadelphia-chromosome positive acute lymphoblastic leukemia (Ph+ ALL)
Abstract Introduction: Amongst patients (pts) ≥ 50 years old diagnosed with B-ALL, half have Ph+ ALL. Achieving a BCR::ABL1 qRT-PCR of &...
Immune-based risk score derived from bulk and single-cell transcriptomics enhances prognostic stratification in MDS
Abstract Background Bulk RNA sequencing is a powerful and cost-effective high-throughput technology that provides comprehensive insights int...
Preoperative platelet transfusion in cancer surgery: Outcomes across and above guideline thresholds
Abstract Background: Thrombocytopenia is common in patients with malignancy and frequently encountered prior to surgery. Perioperative guide...
Restarting etentamig therapy after dosing delays or interruptions: Population pharmacokinetics (PopPK) and PK/PD simulations and supporting clinical data
Abstract Introduction Etentamig (ABBV-383) is a differentiated B-cell maturation antigen (BCMA) x CD3 bispecific antibody (fully humanized I...
Outcomes of elderly patients with newly diagnosed multiple myeloma (NDMM): A retrospective comparison of daratumumab-based induction versus autologous stem cell transplant (autoSCT)
Abstract Introduction: AutoSCT is often considered for fit patients up to the age of 75. However, the MAIA trial showed that transplant-inel...
Therapeutic targeting of focal adhesion kinase (FAK) modulates oncogenic and immune pathways in myeloid progenitor cells expressing oncogenic Janus kinase 2-V617F.
Abstract Introduction: Myeloproliferative neoplasms (MPNs) are clonal blood cancers marked by excessive production of mature myeloid cells. T...
Association of infection frequency and incident clonal hematopoiesis
Abstract Background: Clonal hematopoiesis (CH) is an age-related phenomenon in which hematopoietic stem cells acquire somatic mutations that...
Inflammatory and oxidative stress biomarkers associated with cognitive function in patients with Hodgkin lymphoma treated with chemotherapy
Abstract Background: Cancer-related cognitive impairment (CRCI) is a common and clinically significant issue among cancer patients, negativel...
Real-world evidence of improved survival with pola-based regimen in newly diagnosed DLBCL patients with extranodal involvement
Abstract Background: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease, with extranodal (EN) involvement in nearly 50% of new...