Blood
Articles in this Issue
Metronomic dose decitabine therapy for TP53 complex karyotype myeloid neoplasms
Abstract Introduction: Hypomethylating agent and venetoclax (VEN)–based therapy has transformed the treatment landscape for older adults wit...
Novel risk stratification of ph-like ALL cohort receiving CD19-directed CAR-T therapy
Abstract Background: Preliminary studies, including ours, have demonstrated that CAR-T (CAR19) therapy confers suboptimal therapeutic effica...
Comparable response rates to therapies in idiopathic multicentric castleman disease patients with and without expert-confirmed diagnoses
Abstract Background Idiopathic multicentric Castleman disease (iMCD) is a rare, cytokine-driven disorder defined by lymphadenopathy, distinc...
HIV infection and survival of diffuse large B-cell lymphoma in the era of combined antiretroviral therapy: Comparative and trend analysis
Abstract Background Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma and a frequ...
What remains matters: Real-world impact of measurable residual disease testing in multiple myeloma
Abstract Introduction: Therapeutic options for multiple myeloma (MM) have evolved rapidly with the introduction of proteasome inhibitors, im...
PIM1 mutation drives ANXA2 membrane relocalization and promotes lymphomagenesis through PI3K/AKT/mTOR pathway in DLBCL
Abstract Background ：Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma and we have observed high muta...
International, prospective study comparing nilotinib versus imatinib with early switch to nilotinib to obtain sustained treatment-free remission (TFR) in patients with chronic myeloid leukemia: The tfr rate at the end of follow-up
Abstract Background Today, an important final endpoint in the management of chronic phase chronic myeloid leukemia (CP-C...
Aspirin use among patients with thrombotic antiphospholipid antibody syndrome
Abstract Introduction Antiphospholipid syndrome (APS) is a leading acquired cause of thrombotic events and pregnancy morbidity in the United...
High HLA evolutionary divergence mismatch increases the risk of acute graft-versus-host disease and mortality after haploidentical hematopoietic stem cell transplantation
Abstract Background HLA evolutionary divergence (HED) quantifies physicochemical differences between HLA protein sequenc...
Experience with post-transplant cyclophosphamide (PTCy) for GVHD prophylaxis in HLA-matched related donor HSCT in pediatric and adult patients. evidence of real-life outcomes from a Latin American transplant center.
Abstract Introduction: Post-transplant cyclophosphamide based prophylaxis against graft-versus-host disease (GVHD) has been widely used in t...
Tumor clearance, T-cell fitness, and minimal residual disease (MRD) outcomes in patients with relapsed/refractory multiple myeloma (RRMM) treated with cevostamab plus pomalidomide and dexamethasone: Biomarker analyses from CAMMA 1 Arm B
Abstract Background Fc receptor-homolog 5 (FcRH5) is a type I membrane protein that is ubiquitously expressed on multiple myeloma cells. Cev...
Impact of antibiotic timing on survival outcomes in CD19 and BCMA CAR-T cell therapy
Abstract Introduction: Patients undergoing chimeric antigen receptor T-cell (CAR-T)therapy are often treated with antibiotics in the post CA...
Comparative trends in mortality from acute lymphoblastic and Acute Myeloid Leukemia in the United States: A CDC wonder analysis (1999–2020)
Abstract Background Acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) are the most common forms of acu...
Impact CD34+ cell doses and allograft composition on acute graft-versus-host disease: A single-center prospective cohort study
Abstract Acute graft vs host disease (aGVHD) is a major cause of morbidity and mortality in allogeneic hematopoietic stem cell transplant (a...
Nationwide trends in cardiac arrest and fatal arrhythmias-related mortality in patients with plasma cell disorders: A CDC wonder analysis, 2018–2023
Abstract Background: Cardiac arrest and malignant arrhythmias are major contributors to mortality in patients with plasma cell disorders. Un...
Ophthalmic manifestations of antiphospholipid syndrome
Abstract Introduction: Antiphospholipid syndrome (APS) is an acquired, systemic autoimmune disorder characterized by mac...
An implementation science approach to optimize adoption of hematopoietic cell transplant survivorship care plans
Abstract Background Allogeneic hematopoietic stem cell transplant (HCT) recipients are at risk for late complications that can impact their...
Integrated multi-omic profiling identifies molecular subtypes and predicts outcomes in newly diagnosed peripheral T-cell lymphomas
Abstract Introduction Peripheral T-cell lymphomas (PTCLs) comprise a heterogeneous group of aggressive hematological malignancies, accountin...
Consistent benefits of pegcetacoplan treatment in PNH patients with and without a history of aplastic anemia in real world: Analysis of the ongoing COMPLETE Phase IV observational study
Abstract Introduction PNH is a rare disease characterized by complement-mediated hemolysis. Pegcetacoplan (PEG), a C3/C3b inhibitor approved...
Respiratory failure from viral infections in adults with indolent lymphomas: A national study
Abstract Background: Indolent B-cell lymphomas, including follicular lymphoma (FL), marginal zone lymphoma (MZL), small lymphocytic lymphoma...
Real-world incidence of treatment-emergent cardiovascular events among chronic lymphocytic leukemia/small lymphocytic lymphoma patients receiving acalabrutinib or zanubrutinib monotherapy
Abstract Background: Second-generation Bruton's tyrosine kinase inhibitors (BTKis), including acalabrutinib (acala) and zanubrutinib (zanu),...
The geographical distribution of clonal hematopoiesis-associated mutations among patients diagnosed with myeloid neoplasms
Abstract Background: The presence of clonal hematopoiesis driver mutations has been associated with an increased risk of developing hematolo...
Aberrant autophagy in TET2-deficient macrophages exacerbates foam cell formation
Abstract Clonal hematopoiesis of indeterminate potential (CHIP), defined as presence of somatic mutations in the blood in genes described to...
A randomized, double-blind, placebo-controlled study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple ascending doses of CTO1681 (GP1681) in healthy adult participants
Abstract CytoAgents is developing CTO1681 as an orally available immunomodulatory agent capable of reducing the exaggerated inflammatory res...
Epcoritamab with rituximab + lenalidomide (R2) and epcoritamab maintenance deliver deep and durable remissions in previously untreated (1L) follicular lymphoma (FL): 3-year outcomes from epcore NHL-2 arms 6 and 7
Abstract Introduction: Most patients (pts) with newly diagnosed FL receive chemotherapy (chemo)-containing regimens. While R² offers a chemo...