Blood
Articles in this Issue
Brentuximab vedotin plus DHAP as effective salvage therapy in CD30+ peripheral T-cell lymphoma: A retrospective multicenter study
Abstract The prognosis of most nodal peripheral T-cell lymphomas (T-NHL) has not significantly improved over the past 25 years. Stage- or IP...
Real-world outcomes of autologous CD19-directed CAR T-cell therapy in relapsed/refractory large B-cell lymphoma: A single-center experience
Abstract Introduction Chimeric antigen receptor T-cell therapy (CART) has emerged as a pivotal treatment option for pati...
Sphingosine-1-phosphate receptor modulators overcome FLT3 inhibitor resistance in Acute Myeloid Leukemia with FLT3-ITD and NRAS mutations through sphingosine kinase 1/AKT pathway downregulation.
Abstract Background FLT3-ITD is present in acute myeloid leukemia (AML) in 25% of patients and is associated with poor treatment outcomes. FL...
The role of neutrophil extracellular traps in thrombosis of paroxysmal nocturnal hemoglobinuria
Abstract Background Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematopoietic stem cell disorder caused by PIGA mutations, charact...
Advancing risk prediction in sickle cell disease through multi-task deep learning of mortality and intermediate risk factors
Abstract Sickle cell disease (SCD) displays a wide spectrum of clinical severity that becomes more apparent with age. Transplantation and ge...
EZH2 oncogenic mutation disrupts germinal center B cell dynamics and promotes early lymphomagenic behaviors
Abstract A major clinical challenge in germinal center (GC)-derived lymphomas, such as follicular lymphoma (FL) and diffuse large B-cell lym...
The CSMD1 gene is involved in hematopoietic stem cell HSC pruning in patients with acquired immune-mediated aplastic anemia
Abstract Introduction Somatic mutations in Hematopoietic Stem Cells and Progenitors (HSC/HCP) are very frequent in patie...
Interferon-induced cell senescence as a novel mechanism of eculizumab resistance in transplant associated thrombotic microangiopathy
Abstract Eculizumab significantly increased survival in patients with transplant associated thrombotic microangiopathy (TA-TMA), however one...
Sickle cell disease treatment with arginine therapy (STArT) – results of a phase-3 randomized controlled trial
Abstract Background: Vaso-occlusive pain episodes (VOE) are the leading cause of emergency department (ED) visits and hospitalizations for p...
Mechanical thrombectomy: Long-term risk for venous thromboembolism recurrence
Abstract Introduction Venous thromboembolism (VTE) represents a major cause of cardiovascular morbidity, with mechanical thrombectomy (MT) i...
Acute Myeloid Leukemia with deletion 12p: An adverse-risk disease
Abstract Introduction: AML is risk categorized based on the presence and cooperation of certain cytogenetics and molecular characteristics....
Updated results from the frailty-stratified, randomised controlled bayesian adaptive trial of bortezomib versus lenalidomide in transplant ineligible myeloma (TI NDMM) – the FRAIL-m study (AMaRC 19-01; ALLG MM22)
Abstract Introduction: Real-world survival for TI NDMM patients (pts) is inferior to transplant eligible (TE)-NDMM pts with median OS of 48...
Patient perspectives and preferences for step-up dosing and treatment with teclistamab and talquetamab: Insights from a patient survey
Abstract Background Teclistamab (Tec) and Talquetamab (Tal) are the two first FDA approved bispecific antibodies (BsAb) for the treatment of...
ITCC-101/APAL2020D: A randomized Phase 3 trial of fludarabine/cytarabine/gemtuzumab ozogamycin with or without venetoclax in children with relapsed Acute Myeloid Leukemia
Abstract Background Despite improvements in the treatment of children with acute myeloid leukemia (AML) with modern multi-agent therapy, sur...
Social isolation and patient-reported and healthcare utilization in adults with sickle cell disease
Abstract Background Adults with sickle cell disease (SCD) endure immense physical and psychological suffering related to their illness. Pati...
Post-transplant maintenance with revumenib in children with HOX-driven AML
Abstract Background: Children with HOX-driven AML, including KMT2A or NUP98 rearrangements (KMT2Ar, NUP98r), have poor outcomes, particularly...
Distinct predictors of mortality and conduction disease in AL cardiac amyloidosis
Abstract Introduction: For hematologists managing light-chain (AL) cardiac amyloidosis, risk stratification is complicated by the dual threat...
Trial in progress: Open-label dose-finding and dose-expansion study to evaluate the safety, expansion, persistence, and clinical activity of UCART20x22 in subjects with relapsed or refractory B-cell non-Hodgkin lymphoma (B-NHL) nathali-01
Abstract Background: Despite significant advances in the treatment of B-cell non-Hodgkin's lymphoma, new treatment approaches are needed for...
Extended treatment-free hospitalization-free time and quality of life benefits with CAR T-cell therapy in subgroups of patients with relapsed/refractory MM: Insights from the KarMMa-3 trial
Abstract Introduction: Many treatments for relapsed/refractory multiple myeloma (RRMM) require treat-to-progression, which can result in cum...
Performance of molecular classifiers relative to the international prognostic index (IPI) for overall and event-free survival in diffuse large B-cell lymphoma (DLBCL)
Abstract Over the past decade, classification systems using high-throughput genetic data have been developed to identify molecular subtypes...
Racial disparities in treatment initiation and early outcomes among patients with multiple myeloma: A real-world, multi-institutional cohort study
Abstract Background: Despite therapeutic advances in multiple myeloma (MM), racial disparities in treatment access and outcomes persist. Pri...
The early discharge clinic: A safe and efficient model for intensive outpatient management of hematologic malignancies
Abstract Hematologic malignancies often necessitate complex treatment regimens that can result in prolonged hospitalizations, increasing hea...
Outcomes of relapsed or refractory mature T/NK-cell lymphomas in the era of novel agents: A nationwide observational Study in Japan
Abstract Background: Mature T-cell and natural killer-cell lymphomas (MTNKLs) are often refractory to conventional treatment and associated...
Fusion transcript dynamics as predictor of optimal molecular response in core-binding factor Acute Myeloid Leukemia
Abstract Background: Core binding factorfactor (CBF) leukemias are defined by presence of unique translocation events; t(8;21)(RUNX1::RUNX1T...
National cross-sectional Study to explore current state of patient awareness of multiple myeloma (MM) disease basics and its management: Identifying gaps and associations
Abstract Background: MM is the second most common hematologic malignancy, which despite significant therapeutic advancements, remains incura...