Proceedings of the National Academy of Sciences
Articles in this Issue
Harnessing hemostasis to transform surgical scars into CAR-T immunological niches
Proximity-driven acceleration of challenging solid-phase peptide couplings
Many important solid-phase synthesis reactions proceed slowly and inefficiently, for example, the coupling of an activated ester to a sterically hindered, bead-displayed amine, a critical step in the...
Correction for Curtis et al., Fragmentation signatures in cancer patients resemble those of patients with vascular or autoimmune diseases
RPA-independent activation of the ATR/CHK1 pathway
The ATR/CHK1 pathway governs a crucial intra-S-phase checkpoint that safeguards genome stability under replication stress by stabilizing stalled replication forks and ensuring high-fidelity DNA replic...
Reply to Compton et al.: Another paradoxical misunderstanding
Deglacial stratification of the polar Southern Ocean
It is widely accepted that meltwater from northern ice sheets drove changes in the Atlantic Meridional Overturning Circulation, impacting global climate. In contrast, data are lacking on the Antarctic...
For reducing premature adult mortality in India, education matters more than income
Preventing premature death is a global policy objective reflected in the SDGs. While numerous studies have found socioeconomic factors to be significantly associated with premature death everywhere in...
Neuron-specific modulation of SLC30A10 identifies dopaminergic and glutamatergic neurons as targets of manganese-induced motor disease
Essential metals accumulate in the basal ganglia at elevated levels and induce incurable motor disease. But, unlike other motor diseases, the neuronal targets of essential metals are unknown, and this...
Divergent understandings in comparative oncology
Evolution of Pliocene-Pleistocene tropical terrestrial Andean temperature amplification
The Pliocene is the most recent epoch in which the Earth warmed under atmospheric CO 2 levels similar to today (>400 ppm). The Pliocene then transitioned to...
Selective peroxynitrite-mediated protein nitration catalyzed by glyoxalase domain containing protein 4
Tyrosine nitration alters the structure, function, and cellular localization of proteins and is implicated in the pathology of multiple diseases [G. Ferrer-Sueta et al....
Early psychosocial deprivation alters the refinement of neural dynamics across adolescence
Adolescence is a crucial period for the refinement of neural circuits and cognitive skills. During this time, executive functions mature alongside pronounced structural changes in the brain, including...
Lead in archived hair documents a decline in lead exposure to humans since the establishment of the US Environmental Protection Agency
Lead (Pb) is well known to be toxic to humans. We use archived hair from individuals living along the Wasatch Front in Utah to evaluate changes in exposure to lead over the last 100 y. Current concent...
Flagellar rotation comes full circle
Oxidizing pollutants can disrupt nestmate recognition in ants
Eusocial hymenoptera recognize nestmates based on colony-specific profiles of cuticular hydrocarbons (CHCs). While these profiles contain a variety of alkanes, the less abundant alkenes are crucial fo...
Noncircular rolling contact joints enable programmed behavior in robotic linkages
Rolling contact joints (RCJs) guide motion in robotic linkages, including manipulators, surgical devices, prosthetics, and more. In this work, we present a generalized optimization method to tailor th...
Projecting nitrous oxide over the 21st century, uncertainty related to stratospheric loss
Extending the N 2 O lifetime derived from Microwave Limb Sounder satellite observations, we find a mean value of 117 y and a likely decrease of –1.4 ± 0.9% per...
Toddlers expect ingroup loyalty to override personal preferences when outgroups are present
When outgroups are present, adults may endorse ingroup choices that are at odds with their personal preferences, in an outward show of ingroup loyalty. Here, we examined whether 2-y-old toddlers (...
Correction for Yi et al., Underestimated input of terrestrial dissolved organic carbon to the ocean
Correction for Vierock et al., Multicolor photoreactions of the red light–activated channelrhodopsin Chrimson
Next-generation anti-DLL3 radiopharmaceuticals targeting high-grade neuroendocrine lung and prostate cancers
Delta-like ligand 3 (DLL3) is a tumor-selective cell surface protein upregulated in high-grade neuroendocrine tumors, including small-cell lung cancer (SCLC) and neuroendocrine prostate cancer (NEPC)....
PLETHORA–autophagy axis activates organ regeneration through ROS modulation
Injury-induced disruption of cellular homeostasis leads to accumulation of stress at sites adjacent to a wound. How do these cells mitigate wound-induced stress and restore cellular homeostasis to pro...
Diets, dominance hierarchies, and kleptoparasitism drive asymmetrical interactions between wolves and cougars
After widespread extirpation, conservation efforts have restored large carnivores to portions of their former range. Substantial research has since focused on their ability to alter ecological communi...
Ancestral and local adaptation contribute to dispersal out of the Qinghai–Tibet Plateau in a bumblebee
The Qinghai–Tibet Plateau (QTP) region is the greatest hotspot of social bumblebee diversity worldwide. However, how the high diversity of bumblebees in the QTP evolved and contributed to their divers...
Evidence for the earliest hominin use of wooden handheld tools found at Marathousa 1 (Greece)
The Middle Pleistocene (MP; ca. 774 to 129 ka) marks a critical period of human evolution, characterized by increasing behavioral complexity and the first unambiguous evidence of plant-based technolog...