Proceedings of the National Academy of Sciences
Articles in this Issue
A soft electrode array with reconfigurable hydrogel interfaces for high-fidelity neurophysiological monitoring during craniotomy
Achieving accurate monitoring of electrophysiological activity from the brain cortex is critical for preventing postoperative neurological deficits during craniotomy. However, current technologies fac...
Single-cell analyses identify independent aging processes that compete to determine cellular fate in budding yeast
Phenotypic heterogeneity is prevalent during aging, yet its underlying molecular drivers remain poorly understood. In budding yeast, two distinct aging trajectories, characterized by either ribosomal...
Lithosyntrophy: Obligate syntrophy in a phosphite-oxidizing, methanogenic culture
The anaerobic conversion of organic matter to methane and carbon dioxide typically relies on obligate syntrophic interactions between bacteria and methanogenic archaea, where interspecies electron tra...
FDA must regulate stem cell therapies to mitigate risks to patients and the public
Phase separation of DDHD2 remodels lipid metabolism to dictate treatment sensitivity in luminal breast cancer
Luminal breast cancer is characterized by a persistent risk of recurrence and dysregulated lipid metabolism. However, the role of phase separation, a novel mechanism for the spatial compartmentalizati...
SypC, a symbiont outer membrane vesicle protein, impacts the development of the squid–vibrio partnership
Bacterial outer membrane vesicles (OMVs) and the cargo they carry are increasingly recognized as a means of communication between microbial symbionts and the cells of their host. However, few studies...
Conserved use of tetraspanin CD9 as an entry receptor by rhabdoviruses spanning multiple genera
Rhabdoviruses exhibit a broad host range, yet the cellular receptors underlying their cross-species tropism remain poorly defined. Here, we identified tetraspanin CD9 as a conserved functional entry r...
Quantum-inspired entanglement between collaborating brains during human memory encoding
The extent to which two brains align during information processing is thought to be central to collaborative memory encoding; however, the neural mechanisms that support such interpersonal alignment r...
Smooth-to-rough morphotype switching, a mechanism of phage resistance in <i> <i>Mycobacterium</i> abscessus </i>
Mycobacterium abscessus infections represent a growing global health concern due to their severe pathology and difficulty of treatment, l...
Personalized functional topography–based multisite brain age prediction modeling reveals divergent neurodevelopment in major depression
Major depressive disorder (MDD) is associated with widespread alterations in functional brain networks across the lifespan. However, heterogeneity in atypical brain development among patients with MDD...
Viral mimicry may help explain immunogenic cell death
Viral mimicry may be an underappreciated contributor to chemotherapeutic potency in animal models and patients. This hypothesis is based on studies of a bis-Au(I)-NHC complex that was found to generat...
Correction for Jaen Maisonet et al., Small-molecule allosteric activator of ubiquitin-specific protease 7 (USP7)
Gut microbiome–produced bile acid metabolite lengthens the circadian period in host intestinal cells
Host circadian signaling, feeding, and the gut microbiome are tightly interconnected. Changes in the gut microbial community can affect the expression of core clock genes, but the specific metabolites...
BRCA1-A and LIG4 complexes mediate ecDNA biogenesis and cancer drug resistance
Extrachromosomal circular DNA (ecDNA) is frequently generated within the nucleus, contributing to genome dynamics and heterogeneity, thereby promoting cancer cell evolution and adaptation. However, th...
Directed differentiation of bovine trophoblast stem cells: A useful in vitro model for placenta development
Cattle have a synepitheliochorial type of placenta characterized by placental cotyledons and maternal endometrial caruncles forming placentomes that are essential for fetal development to term. As the...
Locus coeruleus–amygdala circuit disrupts prefrontal control to impair fear extinction
Stress undermines extinction learning and hinders exposure-based clinical therapies for a variety of neuropsychiatric disorders. In both animals and humans, dysfunction in the ventromedial prefrontal...
Correction for Liu et al., A distinct LHCI arrangement is recruited to photosystem I in Fe-starved green algae
Moiré collapse and Luttinger liquids in twisted anisotropic homobilayers
We introduce twisted anisotropic homobilayers as a distinct class of moiré systems, characterized by a distinctive “magic angle,”...
Modulation of electronic structure via dual moiré patterns in twisted 1 <i>T</i> -TaSe <sub>2</sub>
We investigate a twisted bilayer of 1 T -TaSe 2 (twist angle...
Bridging developmental and statistical approaches to variation and evolution
Phenotypic variation is the raw material for evolutionary diversification and adaptation. However, a critical gap remains in evolutionary theory between developmental and statistical representations o...
Ubiquitin-specific peptidase-19 links TDP-43 aggregation to ER stress
Aggregation and deposition of TAR DNA-binding protein 43 (TDP-43) is a salient pathological signature of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration-TDP (FTLD-TDP). TDP-4...
Histone modification clocks for robust cross-species biological age prediction and elucidating senescence regulation
Histone modifications represent an untapped resource for biological age prediction that overcomes limitations of traditional DNA methylation-based epigenetic clocks. Here, we developed and validated h...
Collective bacterial condensation is fundamentally constrained by the emergence of active turbulence
Collective bacterial condensation arises from positive feedback between the ability of bacteria to generate chemical gradients in their environment and their chemotactic ability to follow those gradie...
Sleep deprivation exhibits an age-dependent effect on infraslow global brain activity
Infraslow (<0.1 Hz) global brain activity, quantified by the global mean blood-oxygenation-level-dependent (gBOLD) signal in resting-state functional magnetic resonance imaging (fMRI), is elevated...
Electron localization in noncompact covalent bonds captured by the r <sup>2</sup> SCAN+ <i>V</i> approach
In density functional theory, the SCAN (Strongly Constrained and Appropriately Normed) and r 2 SCAN (regularized–restored SCAN) functionals significantly improv...