Proceedings of the National Academy of Sciences
Articles in this Issue
Maternal Krüppel-like factor 2 (KLF2)+ CD4 T cells promote fertility and fetal tolerance
Pregnancy requires expanded maternal tolerance to semiallogeneic fetal-expressed antigens to protect against fetal loss and other pregnancy complications. Our understanding of how this biological impe...
Targeting the ANGPTL4/NRP1/ABL1/RAD51 axis reverses cisplatin resistance by impairing DNA damage repair in head and neck cancer
Drug chemoresistance remains a major reason of treatment failure in cancer patients. In head and neck squamous cell carcinoma (HNSCC), the seventh most common cancer worldwide, cisplatin chemotherapy...
VAMP8 function reveals tight linkage between endocytic recycling and endocytosis
Clathrin-mediated endocytosis (CME) is a multistage process that involves the initiation and stabilization of clathrin-coated pits (CCPs) that invaginate and finally detach from the plasma membrane to...
Large future genetic diversity losses are predicted from conservation indicators even with habitat protection
Genetic diversity within species underpins evolutionary adaptation and has recently been included as a target for protection in the United Nations’ Global Biodiversity Framework (GBF). Yet, we lack ma...
Multigenerational and gender-symmetric transmission of migration behaviors in historical Quebec
Migration decisions are embedded in social and family trajectories that escape traditional data sources, which tend to observe individuals in isolation. Genealogical microdata now make it possible to...
Correction for Liaño-Pons et al., Combined targeting of PRDX6 and GSTP1 as a potential differentiation strategy for neuroblastoma treatment
Controlled propagation of soliton bullets in an engineered strain field
Predicting and controlling the propagation of nonlinear responses in materials is critical to a range of fields, from the manipulation of single electrons in quantum optics to the understanding of cra...
Energy landscape statistics and thermodynamics of a machine-learned model of water
Water’s anomalous thermodynamic behavior arises from the presence of intricate hydrogen-bond networks that are highly sensitive to many-body interactions, challenging molecular modeling for decades. T...
Monoclonal antibodies from COVID-19 convalescent patients target cryptic epitopes for broad SARS-CoV-2 neutralization
The COVID-19 pandemic, which has resulted in over seven million global fatalities, poses a substantial threat to public health and precipitated a global economic crisis. Emerging variants of concern (...
Uncovering the embodied dimension of the wandering mind
When at rest, the mind becomes preoccupied with self-generated thoughts, commonly known as mind-wandering. While the social, autobiographical, and temporal features of these thoughts have been extensi...
Receptor sequence divergence, gain, loss, duplication, and neofunctionalization drive olfactory adaptation in <i>Drosophila suzukii</i>
Shifts in ecological niches are often driven by evolutionary changes in the olfactory system, yet the underlying mechanisms remain poorly understood. To investigate this, we used D...
Immune cell profiling reveals expanded stem cell–like memory T cells in anti-GAD65-associated neurological syndromes
The immunopathogenesis of autoimmune neurological syndromes (AINS) with antibodies against the 65 kDa isoform of glutamic acid decarboxylase (anti-GAD65 AINS) remains poorly understood. To elucidate u...
Cnpy1 is a candidate endoplasmic reticulum chaperone of vomeronasal type 2 GPCRs
Mouse vomeronasal sensory neurons are continuously generated from stem cells and differentiate to express either V1R or V2R G protein–coupled receptors (GPCRs), along with their respective Gαi2 or Gαo...
Microstrain-engineered platinum nanoclathrins for fuel cells
Proton exchange membrane fuel cells (PEMFCs) hold great promise for clean energy conversion, yet their performance is limited by insufficient mass transport bottlenecks within the catalyst layer. Addr...
Genomic epidemiology of <i>Salmonella</i> and <i>Campylobacter</i> in poultry production: Quantifying the contribution of primary breeders
The US broiler production system processes over 9.3 billion chickens annually through a highly integrated pyramid structure where two primary breeding companies supply genetic stock to approximately 4...
Tyrosine phosphoproteome profiling identifies cell-intrinsic signals limiting the efficacy of tyrosine kinase inhibitor therapies
Tyrosine kinases (TKs) are frequently mutated or overexpressed in cancer, and TK inhibitors (TKIs) are an important therapeutic modality against TK-driven cancers, but many patients show an underwhelm...
Ultrasound-responsive liposomes: A mechanistic framework to decode the effects of acoustic parameters
Ultrasound offers a noninvasive, clinically relevant means to achieve precise spatiotemporal control of cargo release from ultrasound-responsive drug delivery systems within deep tissues. This approac...
Global stability of ecological and evolutionary dynamics via equivalence
The replicator and the Generalized Lotka–Volterra equations are closely related, foundational models in evolutionary game theory and community ecology, respectively. The concept of evolutionary stabil...
PHGDH phosphorylation mediated by WNK1 serves as a dual marker of metabolic vulnerability and responsiveness to oxaliplatin treatment
Metabolic reprogramming is a fundamental hallmark of cancer progression. However, the oncogenic mechanisms underlying serine metabolism and its impact on chemotherapeutic sensitivity in gastric cancer...
Tau catalyzes amyloid-β aggregation and toxicity in a polymorph-dependent manner
Interactions between amyloidogenic proteins are emerging as critical drivers of neurodegenerative diseases. Among others, in Alzheimer’s disease (AD) and severe forms of chronic traumatic encephalopat...
Polypharmacology of S-1117, an Fc-fused IgG-selective degrading enzyme, for chronic treatment of autoantibody-mediated diseases
Antigen-specific immunoglobulin-G (IgG) antibodies cause or contribute to the pathogenesis of a wide spectrum of human diseases and conditions. Multiple therapeutic approaches have been developed, yet...
Neural signatures of human psychological resilience driven by acute stress
Neurophysiological mechanisms underlying psychological resilience—the ability to overcome adversity—have been extensively studied in animals. However, compared to that in animals, human resilience is...
A conserved ethylene-triggered cell death mechanism may underlie hollow stem formation across plant species
Hollow stems have independently evolved multiple times across the plant kingdom and play crucial roles in plant development and various environmental adaptations. However, the mechanisms underlying st...
A modular platform for Sterically Masked Activated Cytokines (SMACks)
Cytokines are critical signaling molecules, but their therapeutic potential remains unrealized due to pleiotropic effects across cell types. Current strategies to develop conditionally active cytokine...
Data-driven Mori–Zwanzig modeling of Lagrangian particle dynamics in turbulent flows
The dynamics of Lagrangian particles in turbulence play a crucial role in mixing, transport, and dispersion in complex flows. Their trajectories exhibit highly nontrivial statistical behavior, motivat...