Immune cell profiling reveals expanded stem cell–like memory T cells in anti-GAD65-associated neurological syndromes

S Sumanta Barman (Department of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University) M Martijn van Duijn (Department of Neurology, Erasmus MC University Medical Center) M Madeleine Scharf (Institute for Experimental Immunology, affiliated to Euroimmun Medizinische Labordiagnostika Aktiengesellschaft) M Marisol Herrera-Rivero (Institute of Epidemiology and Social Medicine, University of Münster) P Paul Disse (Department of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University) L Lara-Maria Preuth (Department of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University) V Valeria Gulyaeva (Department of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University) I Ilja Schwan (Department of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University) E Eliza vom Stein (Department of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University) M Michael Heming (Department of Neurology, University Hospital Münster) L Louisa Müller-Miny (Department of Neurology, University Hospital Münster) M Manuela Paunovic (Department of Neurology, Erasmus MC University Medical Center) E Ebru Haholu (Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität München) J Jan Bartosch (Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität München) E Elisabeth Kaufmann (Department of Neurology, University Hospital) S Sabine Kahl (Institute for Clinical Diabetology, German Diabetes Center (Deutsches Diabetes-Zentrum), Leibniz Center for Diabetes Research at Heinrich Heine University) E Eric Bindels (Department of Hematology, Erasmus MC University Medical Center) H Heinz Wiendl (Institute for Neurology and Neurophysiology, Faculty of Medicine, University of Freiburg) N Nikolas H. Stoecklein (Department of General, Visceral and Pediatric Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University) J Johannes Fischer (Institute for Transplantation Diagnostics and Cell Therapeutics, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University) N Norbert Goebels (Department of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University) L Lars Komorowski (Institute for Experimental Immunology, affiliated to Euroimmun Medizinische Labordiagnostika Aktiengesellschaft) M Michael Roden (Institute for Clinical Diabetology, German Diabetes Center (Deutsches Diabetes-Zentrum), Leibniz Center for Diabetes Research at Heinrich Heine University) A Andrea Rossi (Genome Engineering and Model Development Lab, Institut für umweltmedizinische Forschung-Leibniz Research Institute for Environmental Medicine) M Monika Stoll (Department of Genetic Epidemiology, Institute of Human Genetics, University of Münster) A Albert J. Becker (Institute of Cellular Neurosciences II, University Hospital Bonn) M Motaz Hamed (Clinic for Neurosurgery, University Hospital of Bonn) C Christian G. Bien (Department of Epileptology) R Romana Höftberger (Division of Neuropathology and Neurochemistry, Department of Neurology and Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna) J Jan Bauer (Department of Neuroimmunology, Centre for Brain Research, Medical University of Vienna) S Sven G. Meuth (Department of Neurology, Heinrich-Heine University Düsseldorf) M Maarten J. Titulaer (Department of Neurology, Erasmus MC University Medical Center) J Juna M. de Vries M Mariska M. P. Nagtzaam S Suzanne C. Franken Y Yvette S. Crijnen J Juliette Brenner R Robin W. van Steenhoven J Jeroen Kerstens M Marienke A. A. M. de Bruijn A Anna E. M. Bastiaansen R Remco M. Hoogenboezem S Sharon Veenbergen P Peter A. E. Sillevis Smitt M Marwa Al-Dubai L Luise Appeltshauser I Ilya Ayzenberg C Carolin Baade-Büttner A Andreas van Baalen S Sebastian Baatz O Oliver Bähr B Bettina Balint I Iason Bartzokis S Sebastian Bauer A Annette Baumgartner T Tobias Baumgartner A Antonios Bayas S Stefanie Becker S Sonka Benesch R Robert Berger (Fachbereich Chemie, Theoretische Chemie, Philipps-Universität Marburg, Hans-Meerwein-Str. 4, 35032 Marburg, Germany) B Birgit Berger M Martin Berghoff S Sarah Bernsen A Achim Berthele C Christian Bien C Corinna Bien J Julia Bierwith A Andreas Binder S Stefan Bittner D Daniel Bittner F Franz Blaes A Astrid Blaschek A Amelie Bohn M Moritz Böhringer M Marie Braun S Sergio Castro-Gomez J Justina Dargvainiene (Institute of Clinical Chemistry, University Hospital Schleswig-Holstein) T Timo Deba J Julia Maren Decker J Johanna-Maria Dietmaier A Andre Dik J Julian Dominik K Kathrin Doppler M Mona Dreesmann L Lena Edelhoff L Laura Ehrhardt S Sven Ehrlich K Katharina Eisenhut (Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität München) A Alexander Emmer D Dominique Endres M Marina Entscheva-Storr D Daniela Esser (Institute of Clinical Chemistry, University Hospital Schleswig-Holstein) T Thorleif Etgen J Jürgen Hartmut Faiss K Kim Kristin Falk T Timo Faustmann W Walid Fazeli A Alexander Finke C Carsten Finke F Felix Fischbach D Dirk Fitzner M Marina Flotats-Bastardas M Mathias Fousse T Tobias Freilinger M Manuel Friese H Hannah Fuhrer A Armin Johannes Gaebler M Marco Gallus M Marcel Gebhard C Christian Geis C Clemens Gödel A Anna Gorsler A Armin Grau O Oliver Grauer B Britta Greshake C Catharina roß T Thomas Grüter A Aiden Haghikia R Robert Handreka I Iris Hannibal N Niels Hansen (Institute of Thermodynamics and Thermal Process Engineering, University of Stuttgart, Pfaffenwaldring 9, Stuttgart 70569, Germany) S Sandra Hansmann J Jens Harmel A Antonia Harms Y Yetzenia Dubraska Haro Alizo A Alkomiet Hasan M Martin Häusler I Ida Sybille Haussleiter J Joachim Havla C Chung Ha-Yeun W Wolfgang Heide V Valentin Held K Kerstin Hellwig M Marina Herwerth P Philip Hillebrand F Frank Hoffmann C Christian Hofmann U Ulrich Hofstadt-van Oy D Dominica Hudasch (ehem. Ratuszny) Y Yannik Hülsmann M Martinv Hümmert P Peter Huppke H Hagen Huttner F Fatme Seval Ismail M Martina Jansen M Mareike Jansen M Marius Jonas (Department of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University) A Aleksandra Juranek D Daniel Kamp M Michael Karenfort A Annika Kather M Max Kaufmann C Christoph Kellinghaus C Constanze Kerin (geb. Mönig) R Ruth Kerkhoff R Rolf Kern J Jaqueline Klausewitz M Michael Kluge S Susanne Knake B Benjamin Knier E Ellen Knierim F Frank Kohlert I Inga Koneczny F Felix Konen P Peter Körtvélyessy S Stjepana Kovac A Andrea Kraft M Markus Krämer V Verena Kraus C Christos Krogias G Gregor Kuhlenbäumer O Olga Kukhlenko T Tania Kümpfel A Albrecht Kunze H Hanna Lapp C Christoph Lehrich M Martin Lesser J Jan Lewerenz F Frank Leypoldt (Institute of Clinical Chemistry, University Hospital Schleswig-Holstein) A Andreas Linsa D Daniel Lüdecke J Jan Lünemann M Marie Madlener M Michael Malter N Nils Margraf C Carlos Martinez Quesada M Monika Meister N Nico Melzer (Department of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University) K Kristin Stefanie Melzer T Til Menge S Sven Meuth G Gerd Meyer zu Hörste (Department of Neurology, University Hospital Münster) F Fabian Möller M Marie-Luise Mono S Sigrid Mues H Hiltrud Muhle A Anna-Katharina Mundorf M Marc Nikolaus J Jost Obrocki F Friedemann Paul L Loana Penner L Lena Kristina Pfeffer T Thomas Pfefferkorn S Steffen Pfeuffer A Alexandra Philipsen J Johannes Piepgras J Julika Pitsch F Felix von Podewils M Mosche Pompsch J Josef Priller A Anne-Katrin Pröbstel H Harald Prüss (Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin) D Duygu Pul (Department of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University) D Daniel Rapp J Johanna Maria Helena Rau S Saskia Räuber (Department of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University) M Markus Rauchenzauner R Robert Rehmann I Ina Reichen G Gernot Reimann M Momsen Reincke R Raphael Reinecke J Jonathan Repple N Nele Retzlaff S Sigrid Reuter M Marius Ringelstein (Department of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University) H Henrik Rohner F Felix Rosenow K Kevin Rostásy T Theodor Rüber S Stephan Rüegg Y Yannic Saathoff J Jens Schaumberg H Hanna Schellhorn R Ruth Schilling J Jens Schmidt M Melissa Schmitz I Ina-Isabelle Schmütz H Hauke Schneider P Patrick Schramm S Stephan Schreiber S Stefanie Schreiber G Gesa Schreyer I Ina Schröder S Simon Schuster P Philip Schwenkenbecher G Günter Seidel F Frank Seifert T Thomas Seifert-Held M Makbule Senel K Kai Siebenbrodt O Olga Simova C Claudia Sommer J Juliane Spiegler O Oliver Stammel S Slobodan Stankovic A Andreas Steinbrecher J Johann Steiner H Henning Stolze M Muriel Stoppe K Karin Storm van’s Gravesande C Christine Strippel (Department of Neurology, University Hospital Münster) D Dietrich Sturm K Klarissa Hanja Stürner K Kurt-Wolfram Sühs S Steffen Syrbe S Simone Taube F Franziska Thaler (Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität München) F Florian Then Bergh K Katrin Thies A Anja Tietz C Corinna Trebst G George Trendelenburg R Regina Trollmann T Thanos Tsaktanis H Hayrettin Tumani M Mehtap Türedi C Christian Urbanek R Rem Vaizian N Niklas Vogel M Max Vogtmann M Matthias von Mering K Katharina von Zedtwitz J Judith Wagner J Jan Wagner E Elias Wagner (Department of Psychiatry, Psychotherapy, and Psychosomatics, Medical Faculty University of Augsburg) B Barbara Wagner K Klaus-Peter Wandinger M Mirko Wegschneider J Judith Weiser R Robert Weissert N Njiku Melchior Wellmer B Brigitte Wildemann J Jonathan Wickel K Karsten Witt K Katharina Wurdack Y Yavor Yalachkov L Lara Zieger