Proceedings of the National Academy of Sciences
Articles in this Issue
Regulation of antiviral and antitumor immunity by the <i>BRCA1</i> pseudogene in human cancers
Pseudogenes have been regarded as nonfunctional byproducts of evolutionary processes. However, emerging evidence indicates that pseudogenes perform diverse biological roles in human physiology and pat...
Climatic mechanisms underlying a southwestern French Neanderthal refugium at the onset of the last glaciation
Did it all begin with hydrogen cyanide?
Correction for Esposito et al., Three-dimensional high-content imaging of unstained soft tissue with subcellular resolution using a laboratory-based X-ray microscope
A ginsenoside metabolite and its derivative target PRELID3B against lung cancer cells
Ginseng is widely praised for its benefits on cancer patients, often attributed to its metabolite compound K ( CK ). Here, we synthesized a derivative (...
Convergent antibody solutions revealed by focused humanized repertoires
Correction for Osvatic et al., Global biogeography of chemosynthetic symbionts reveals both localized and globally distributed symbiont groups
Correction for Walls et al., The radical SAM enzyme EpeE exhibits distinct site reactivity during the biosynthesis of the RiPP natural product epipeptide
Improving the job market in economics (and beyond…)
Eosinophil-derived COX-2 protects against experimental colitis through the PGE <sub>2</sub> –IL-22 axis
Inflammatory bowel disease (IBD) is driven by a breakdown in immune regulation and epithelial barrier function, yet the contribution of eosinophils to this process has remained poorly defined and cont...
Timing and origins of Mexican and Central American oak diversity
The origins and assembly of temperate biodiversity hotspots remain poorly understood. This knowledge gap is particularly evident in low-latitude montane regions of the Americas, where northern lineage...
Historical legacies shape continental variation in contemporary mammal food webs
Contemporary ecological networks reflect the influence of evolutionary and ecological processes on species interactions. Additionally, late Quaternary megafaunal extinctions and subsequent range contr...
Historic logbooks reveal spatial footprints of commercial whaling
Commercial harvesting of bowhead whales ( Balaena mysticetus ), primarily by British and American whalers during the late-1700s to early-1900s, nearly caused th...
An independent center for the origin of bread wheat in the Neolithic period of Georgia in the South Caucasus
Bread wheat ( Triticum aestivum L.) is the most popular wheat species in the world today. However, studies on the domestication of wheat have rarely focused on...
Repeated snowball–hothouse cycles within the Neoproterozoic Sturtian glaciation
The Neoproterozoic Era was a pivotal era of Earth’s history in which multiple severe glaciations profoundly influenced the biosphere, but explaining the duration and nature of these events remains a m...
Antiretroviral therapy blocks natural selection on protective and disease-susceptible HLA-B alleles in HIV-1 infection
MHC polymorphism is explained by natural selection driven by the MHC-dependent impact of certain infections, inflammatory conditions, autoimmune diseases, and cancers. However, examples of human disea...
Neanderthal brain and cognition reconsidered
Neanderthal endocrania are different in shape, though slightly larger in size than modern humans on average. These shape differences have long been used to suggest Neanderthals differed cognitively fr...