Proceedings of the National Academy of Sciences
Articles in this Issue
Trace fossils constrain the perceptual ranges of the earliest motile animals
The late Ediacaran marks a pivotal interval in early animal evolution, when benthic organisms began engaging with increasingly heterogeneous and dynamic seafloor environments. These shifts signal the...
Rethinking energy transition strategies for the European Union amid rising energy prices
Geopolitical tensions and the disruption of major energy imports have sharply elevated energy prices across the European Union (EU), creating a persistent energy supply gap and posing long-term challe...
“Alternative” or integrated role of mitochondrial glycerol-3-phosphate dehydrogenase
Coordinated expression and assembly of BiP, p58 <sup>IPK</sup> , and ER chaperone complexes maximize proinsulin folding in pancreatic β cells
Proper proinsulin folding in the endoplasmic reticulum (ER) is prerequisite to producing bioactive insulin, and proinsulin misfolding causing β cell ER stress accompanies pancreatic β cell dysfunction...
Crotonylation impedes c-Myc oncogenic activity
c-Myc, an important oncoprotein, is highly regulated via posttranslational modifications. Herein, we report c-Myc crotonylation, an acylation stemming from the short-chain fatty acid crotonate. By bio...
A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance
Pancreatic ductal adenocarcinoma (PDAC) has one of the lowest cancer survival rates. Recent studies using RAS inhibitors have opened the door to more efficacious therapies although their beneficial ef...