Proceedings of the National Academy of Sciences
Articles in this Issue
PANCS-spec-Binders: A system for rapidly discovering isoform- or epitope-specific binders
Proteins that bind to a target protein of interest, termed “binders”, are essential components of biological research reagents and therapeutics. Target proteins present multiple binding surfaces with...
Impacts of future sea level change on Greenland from community knowledge, coastal mapping, and glacial isostatic adjustment models
Making predictions of global change relevant to individual communities is a critical challenge, especially where local impacts diverge from global predictions. While sea level is rising globally, in G...
Beyond temperature: Why climate adaptation in agriculture needs a systems approach
Habitat split drives assembly of less protective host microbiomes
HLA micropolymorphisms confine neoantigen conformational adaptability and guide T cell receptor selectivity
T cell receptor (TCR) restriction by highly polymorphic major histocompatibility complex (MHC) proteins is a foundation of cellular immunity. Although the effects of MHC polymorphisms on peptide bindi...
Navigating the unknown: Nanobubbles and the hidden complexity of aerophilic surfaces
Synthetic pectin–cellulose nanofiber capsule recapitulates the mechanical properties of a regenerating plant cell wall
Plant primary cell walls are dynamic supramolecular assemblies composed of layered cellulose, hemicellulose, and pectin, progressively built through synthesis and secretion. However, the specific arch...
Type I hair cells of striolar and central zones in vestibular organs are essential for head stability and postural control
The vestibular system of the inner ear provides head motion and orientation information required for maintaining balance and spatial orientation. Each of the five vestibular sensory organs contains ty...
From bedside to bench: A multimodal approach uncovering the molecular basis of the <i>MYBPC1</i> -linked Myotrem myopathy
Myotrem is an untreatable, early-onset, congenital myopathy characterized by hypotonia, muscle weakness, skeletal deformities, dysmorphia, respiratory insufficiency, and myogenic tremor (V. Shashi...
Canadian wildfires are losing their climate-cooling influence from postfire snow albedo
The 2023 Canadian fire season was record-breaking in terms of burned area and carbon emissions. Here, we present estimates of the regional climate-cooling effect from postfire surface albedo changes,...
Control of lipid metabolism in chondrocytes is critical for skeletal growth
Chondrodysplasia is a genetic disorder characterized by impaired cartilage development and bone growth. Dysregulation of the endoplasmic reticulum (ER) stress is associated with chondrodysplasia. Here...
Bilingualism predicts executive function resilience after COVID-19 in aging
Bilingualism has been associated with enhanced executive functions (EFs), particularly attentional control, and may confer protection against cognitive decline in older age. At the same time, the COVI...
Did Stora Karlsö wolves reach the island naturally or by boat?
miR-146a is a pleiotropic regulator of motor neuron degeneration
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting motor neurons. Here, we have profiled motor neuron microRNAs (miRNAs) during motor neuron degeneration in vivo...
Resetting population mobility responses under repeated nonpharmaceutical interventions: Implications for hypothesized pandemic fatigue
Nonpharmaceutical interventions (NPIs) are essential for controlling infectious diseases during prevaccine periods, yet their success hinges on sustained population behavioral responses to restriction...
Climate change, inequality, and childhood stunting in African countries
Childhood stunting is associated with increased mortality, higher risk of chronic disease, impaired cognitive development, lower educational attainment, reduced economic opportunities, and intergenera...
Resolving Feynman’s restaurant problem reveals optimal solutions and human strategies
In the 1970s, physicist Richard Feynman turned lunch with a friend into a math problem—how to optimize dish selection over multiple meals—but his handwritten notes remained a mystery for decades. Here...
Reply to Janssens and Mech: The possibility of natural wolf dispersal to Stora Karlsö
Potassium controls skin adaptation in <i>Candida auris</i>
Egress thresholds and wildfire fatalities
Avoiding human fatalities during wildfires is a key public policy objective. Outward road access, or the number of egress routes, is widely assumed to influence wildfire fatalities, yet few studies ha...
Polyphosphate affects the growth and methanogenesis of deep-sea methanogenic archaea
Microorganisms employ inorganic polyphosphate (polyP) as an ancient strategy for energy and phosphate storage, yet its physiological roles in methanogenic archaea remain largely unexplored. Here, we r...
Polyunsaturated fatty acid–derived lipid mediator patterns determine viral pneumonia severity and risk for critical COVID-19
Severe respiratory infections such as COVID-19 are characterized by excessive inflammation leading to the development of pneumonia and acute respiratory distress syndrome. Bioactive lipid mediators (L...
Canonical and variant PRC1 functionally converge on PRC2 targets to regulate transcriptional programs during mouse limb development
The developing limb is a classical model system for studying genetic aspects of pattern formation and mechanisms underlying tissue differentiation. The transition from early to differentiated cell fat...
Memory, chaos, and noise in ecological forecasting
Ecological populations fluctuate for reasons that are often ascribed—separately—to historical legacies, intrinsic nonlinear dynamics, or stochastic noise. Yet these forces rarely act in isolation. We...