Proceedings of the National Academy of Sciences
Articles in this Issue
Measurement accuracy in mechanobiology: A unifying statistical framework for testing cellular forces
Mechanobiology is gaining traction as it reveals the fundamental role of physical forces and mechanical stress in biological function. Because physiologically relevant experiments are often inaccessib...
Stabilization of recurrent neural networks through divisive normalization
Stability is a fundamental requirement for both biological and engineered neural circuits, yet it is surprisingly difficult to guarantee in the presence of recurrent interactions. Standard linear dyna...
Equilibrium and stability of coupled nonlinear energy-storing components
Coupled systems of nonlinear components occur across physics and engineering and can display rich behaviors such as multistability, snap-through, and memory. These phenomena play a key role in physica...
The multilayered cuticle underlying structural coloration in red algae shares features with the metazoan extracellular matrix
Structural coloration, a physical phenomenon observed in many living organisms, may arise from the interference of light with highly organized surface nanostructures. In some seaweeds, these nanostruc...
TBC1D9 and TBC1D9B are ARL8 effectors that modulate exosome secretion through a RAB11A–exocyst pathway
Multivesicular endosomes (MVEs) are endolysosomal compartments containing intraluminal vesicles (ILVs) that follow two alternative pathways: fusion with lysosomes, leading to ILV degradation, or fusio...