Proceedings of the National Academy of Sciences
Articles in this Issue
Human beauty illustrates the economic impact of heritable physical traits
Intergenerational transmission of inequality is a central question in the social sciences. We use one trait, beauty, to infer how much parents’ physical characteristics transmit inequality across gene...
The revised elastic field of an edge dislocation
We modify the traditional linear-elastic field of an edge dislocation. The modifications stem from symmetry and energy requirements imposed in terms of embedded (deformed) coordinates. These requireme...
Identification of a central regulator of ginkgolide biosynthesis in <i>Ginkgo biloba</i> that integrates jasmonate and light signaling
Ginkgolides are secondary metabolites unique to Ginkgo biloba with the potential to prevent and treat cardiovascular and cerebrovascular diseases. Although the...
Biochemical and structural bases for talin ABSs–F-actin interactions
Focal adhesions (FAs) are large intracellular macromolecular assemblies that play a critical role in cell polarization and migration. Talin serves as a direct connection between integrin receptor and...
Human MAIT cell response profiles biased toward IL-17 or IL-10 are distinct effector states directed by the cytokine milieu
Mucosal-associated invariant T (MAIT) cells are unconventional T cells that mediate rapid antimicrobial immune responses to antigens derived from microbial riboflavin pathway metabolites presented by...
Creation, stabilization, and investigation at ambient pressure of pressure-induced superconductivity in Bi <sub>0.5</sub> Sb <sub>1.5</sub> Te <sub>3</sub>
In light of breakthroughs in superconductivity under high pressure, and considering that record critical temperatures (T c s) across various systems have been a...
Quantifying the impact of air pollution from coal-fired electricity generation on crop productivity in India
Air pollution from coal electricity generation is a major driver of poor air quality in India and its effects on human health have been extensively studied. Despite considerable evidence that the same...
High-throughput discovery of inhibitory protein fragments with AlphaFold
Peptides can bind to specific sites on larger proteins and thereby function as inhibitors and regulatory elements. Peptide fragments of larger proteins are particularly attractive for achieving these...
Translation elongation defects activate the <i>Caenorhabditis elegans</i> ZIP-2 bZIP transcription factor–mediated toxin defense
The Caenorhabditis elegans bZIP transcription factor ZIP-2 is activated by toxins or mutations that inhibit translational elongation. The zi...
Light’s hidden power: Vacuum fluctuations reshape superconductivity from within
Yet another twist to the regulation of the TGF-β family ligands
A 5,000-fold increase in the HAT reactivity of a nonheme Fe <sup>IV</sup> =O complex simply by replacing two pyridines of the pentadentate N4Py ligand with pyrazoles
A pentadentate [N5] ligand (N2Py2Pz) based on the classic N4Py ( N,N -bis(2-pyridylmethyl)- N -bis(2-pyridyl)methylamine...
Co-zorbs: Motile, multispecies biofilms aid transport of diverse bacterial species
Biofilms are three-dimensional structures containing one or more bacterial species embedded in extracellular polymeric substances. Although most biofilms are stationary, Flavobacte...
Spatiotemporal distribution of the North American Indigenous population prior to European contact
We examine spatiotemporal trends in the pre-European-contact Indigenous population of North America using radiocarbon ( 14 C) dates of the past 2000 y. At a con...
The Regulatory-associated protein of target of rapamycin 1B (RAPTOR 1B) interconnects with the photoperiod pathway to promote flowering in <i>Arabidopsis</i>
The transition from vegetative to reproductive growth, or floral transition, is a tightly regulated, energy-demanding process. In Arabidopsis , the interplay of...
Active vision in freely moving marmosets using head-mounted eye tracking
Our understanding of how vision functions as primates actively navigate the real-world is remarkably sparse. As most data have been limited to chaired and typically head-restrained animals, the synerg...
Energyscapes pinpoint marine megafauna feeding hotspots in the Mediterranean
Ocean giants shape the structure and functioning of marine food webs via trophic top–down controls, landscapes of fear, vertical and horizontal redistribution of nutrients, energy, and matter. Yet, th...
Bonobos point more for ignorant than knowledgeable social partners
Numerous uniquely human phenomena, from teaching to our most complex forms of cooperation, depend on our ability to tailor our communication to the knowledge and ignorance states of our social partner...
Cataract-prone variants of γD-crystallin populate a conformation with a partially unfolded N-terminal domain under native conditions
Human γD-crystallin, a monomeric protein abundant in the eye lens nucleus, must remain stably folded for an individual’s entire lifetime to avoid aggregation and protein deposition-associated cataract...
The unique reactivity of EKODE lipid peroxidation products allows in vivo detection of inflammation
Lipid peroxidation is a complex biochemical process associated with oxidative stress, and its products play crucial roles in cellular signaling and the pathophysiology of many diseases. Among the dive...
Adoption of improved crop varieties limited biodiversity losses, terrestrial carbon emissions, and cropland expansion in the tropics
Research investments in crop improvements, including by national and international agricultural research centers, have made significant contributions to raising yields of staple food crops in developi...
The C2 domain augments Ras GTPase-activating protein catalytic activity
Regulation of Ras GTPases by GTPase-activating proteins (GAPs) is essential for their normal signaling. Nine of the ten GAPs for Ras contain a C2 domain immediately proximal to their canonical GAP dom...
Bilateral cellular flows display asymmetry prior to left–right organizer formation in amniote gastrulation
A bilateral body plan is predominant throughout the animal kingdom. Bilaterality of amniote embryos becomes recognizable as midline morphogenesis begins at gastrulation, bisecting an embryonic field i...
The estimated cost of preventing extinction and progressing recovery for Australia’s priority threatened species
The global extinction crisis is intensifying rapidly, driven by habitat loss, overexploitation, climate change, invasive species, and disease. This unprecedented loss of species not only threatens eco...
Estimating the legibility of international borders
Researchers in the social sciences are interested in the consequences of institutions, increasingly on a global scale. Institutions that may be negotiated between states can have consequences at a mic...