Proceedings of the National Academy of Sciences
Articles in this Issue
Comparative transcriptomics reveals a mixed basal, club, and hillock epithelial cell identity in castration-resistant prostate cancer
Inhibiting the androgen receptor (AR) is effective for treatment of advanced prostate cancers because of their AR-dependent luminal epithelial cell identity. Tumors progress during therapy to castrati...
HflX-mediated drug resistance through ribosome splitting and rRNA disordering in mycobacteria
HflX is a highly conserved ribosome-associated GTPase implicated in rescuing stalled ribosomes and mediating antibiotic resistance in several bacteria, including macrolide-lincosamide antibiotic resis...
Mec1-mediated Atg9 phosphorylation regulates the PAS recruitment of Atg9 vesicles upon energy stress
Mec1 plays an essential role in both the DNA damage response and glucose starvation–induced autophagy. We recently reported that Mec1 regulates glucose starvation–induced autophagy through its direct...
An ear for an ear, but only if you are a deomyinid
Abscisic acid signaling gates salt-induced responses of plant roots
Soil salinity presents a dual challenge for plants, involving both osmotic and ionic stress. In response, plants deploy distinct yet interconnected mechanisms to cope with these facets of salinity str...
Synergistic anion–π interactions in peptidomimetic polyethers
Anion–π interactions are crucial in various biological processes, such as enzyme catalysis and ion transport. Despite their significance, the exploitation of anion–π interactions in synthetic polymer...
Profile of Bik-Kwoon Tye
QnAs with Jeremy J. Michalek and Corey D. Harper
CO <sub>2</sub> potentiates echinocandin efficacy during invasive candidiasis therapy via dephosphorylation of Hsp90 by Ptc2 in condensates
Carbon dioxide is a signaling cue critical for fungal pathogenesis. Ptc2, a type 2C protein phosphatase (PP2C), serves as a conserved CO 2 sensor in fungi. By c...
Rapid restoration of potent neutralization activity against the latest Omicron variant JN.1 via AI rational design and antibody engineering
The rapid evolution of the viral genome has led to the continual generation of new variants of SARS-CoV-2. Developing antibody drugs with broad-spectrum and high efficiency is a long-term task. It is...
Free-electron resonance transition radiation via Brewster randomness
Free-electron radiation, such as Cherenkov radiation and transition radiation, can generate light at arbitrary frequencies and is fundamental to diverse applications, ranging from electron microscopy,...
Ethylene-independent modulation of root development by ACC via downregulation of WOX5 and group I CLE peptide expression
In seed plants, the canonical role of 1-aminocyclopropane-1-carboxylic acid (ACC) is to serve as the precursor in the biosynthesis of the phytohormone ethylene, and indeed, ACC treatment is often used...
Microtubule inner proteins of <i>Plasmodium</i> are essential for transmission of malaria parasites
Microtubule inner proteins (MIPs) are microtubule-associated proteins that bind to tubulin from the luminal side. MIPs can be found in axonemes to stabilize flagellar beat or within cytoplasmic microt...
Circadian clock control of interactions between eIF2α kinase CPC-3 and GCN1 with ribosomes regulates rhythmic translation initiation
Misregulation of the activity of GCN2, the kinase that phosphorylates and inactivates translation initiation factor eIF2α, has been implicated in several health disorders, underscoring the need to det...
Variable transduction of thyroid hormone signaling in structures of the mouse brain
L-thyroxine (L-T4) monotherapy is the standard treatment for hypothyroidism, administered daily to normalize TSH levels. Once absorbed, T4 is converted to T3 to alleviate most symptoms. However, this...
Spatial propagation of temperate phages within and among biofilms
Bacteria form groups composed of cells and a secreted polymeric matrix that controls their spatial organization. These groups—termed biofilms—can act as refuges from environmental disturbances and fro...
Black and Latinx workers reap lower rewards than White workers from years spent working in big cities
The large labor markets of big cities offer greater possibilities for workers to gain skills and experience through successively better employment opportunities. This “experience effect” contributes t...
Activation-induced thrombospondin-4 works with thrombospondin-1 to build cytotoxic supramolecular attack particles
Cytotoxic attack particles released by CTLs and NK cells include diverse phospholipid membrane and glycoprotein encapsulated entities that contribute to target cell killing. Supramolecular attack part...
Uncovering the hidden RNA virus diversity in Lake Nam Co: Evolutionary insights from an extreme high-altitude environment
Alpine lakes, characterized by isolation, low temperatures, oligotrophic conditions, and intense ultraviolet radiation, remain a poorly explored ecosystem for RNA viruses. Here, we present the first c...
Fixational eye movements as active sensation for high visual acuity
Perception and action are inherently entangled: our world view is shaped by how we explore our environment through complex and variable self-motion. Even when fixating stable stimuli, our eyes undergo...
Spatial Patterning Analysis of Cellular Ensembles (SPACE) finds complex spatial organization at the cell and tissue levels
Spatial patterns of cells and other biological elements drive physiologic and pathologic processes within tissues. While many imaging and transcriptomic methods document tissue organization, discernin...
Observed declines in upper ocean phosphate-to-nitrate availability
Climate warming is increasing ocean stratification, which in turn should decrease the nutrient flux to the upper ocean. This may slow marine primary productivity, causing cascading effects throughout...
Impact of <i>APOE</i> , <i>Klotho,</i> and sex on cognitive decline with aging
The effects of apolipoprotein E ( APOE ) and Klotho genes, both implicated in aging, on human cognition as a function of...
Intracranial substrates of meditation-induced neuromodulation in the amygdala and hippocampus
Meditation is an accessible mental practice associated with emotional regulation and well-being. Loving-kindness meditation (LKM), a specific subtype of meditative practice, involves focusing one’s at...
Engineering drive–selection balance for localized population suppression with neutral dynamics
While the release of sterile males has been highly successful in suppressing some pest populations, it is impractical for many species due to the males disappearing after a single generation, necessit...