Proceedings of the National Academy of Sciences
Articles in this Issue
Revisiting lipid nanoparticle composition and structure: A critical take on simulation approaches
Boosted recovery of rare earth elements from mining wastes and discarded NdFeB magnets by tributyl phosphate–grafted ZIF-8
The escalating demand for rare earth elements (REEs) highlights the necessity for their sustainable recovery from waste streams and secondary resources. However, this process requires materials with e...
Ancient ocean coastal deposits imaged on Mars
The northern lowlands of early Mars could have contained a significant quantity of liquid water. However, the ocean hypothesis remains controversial due to the lack of conclusive evidence from the Mar...
Climate change is leading to an ecological trap in a migratory insect
Many insect migrants rely on favorable seasonal winds to carry out long-range latitudinal migrations. In East China, the annual advance and retreat of the East Asian summer monsoon produces ideal cond...
Structural variant and nucleosome occupancy dynamics postchemotherapy in a HER2+ breast cancer organoid model
The most common chemotherapeutics induce DNA damage to eradicate cancer cells, yet defective DNA repair can propagate mutations, instigating therapy resistance and secondary malignancies. Structural v...
A proper definition of the paddlewheel effect affirms its existence
CTCF regulates global chromatin accessibility and transcription during rod photoreceptor development
Chromatin architecture facilitates accurate transcription at a number of loci, but it remains unclear how much chromatin architecture is involved in global transcriptional regulation. Previous work ha...
Chemical genetic interactions elucidate pathways controlling tuberculosis antibiotic efficacy during infection
Successful tuberculosis therapy requires treatment with an unwieldy multidrug combination for several months. Thus, there is a growing need to identify novel genetic vulnerabilities that can be levera...
Component mechanisms of Gaia: Biogeochemical cycles are special
3A or not 3A: Cytidine deaminases in the etiology of the CAG-repeat expansion diseases
Reply to Trollmann et al.: Perspective on LNP structure and simulation
Rethinking postdoc careers through the science of science
Abrupt changes in algal biomass of thousands of US lakes are related to climate and are more likely in low-disturbance watersheds
Climate change is predicted to intensify lake algal blooms globally and result in regime shifts. However, observed increases in algal biomass do not consistently correlate with air temperature or prec...
The AaFoxA factor regulates female reproduction through chromatin remodeling in the mosquito vector Aedes aegypti
Female mosquitoes are vectors of many devastating human diseases because they require blood feeding to initiate reproduction. Thus, elucidation of molecular mechanisms managing female mosquito reprodu...
No evidence for Peto’s paradox in terrestrial vertebrates
Larger, longer-lived species are expected to have a higher cancer prevalence compared to smaller, shorter-lived species owing to the greater number of cell divisions that occur during their lifespan....
Limited and biased global conservation funding means most threatened species remain unsupported
The conservation of biodiversity represents a global challenge as the world experiences its sixth mass extinction. Understanding how conservation efforts are allocated is paramount to effectively prot...
Ancient genomes reveal trans-Eurasian connections between the European Huns and the Xiongnu Empire
The Huns appeared in Europe in the 370s, establishing an Empire that reshaped West Eurasian history. Yet until today their origins remain a matter of extensive debate. Traditional theories link them t...
Robust encoding of stimulus–response mapping by neurons in visual cortex
Neural activity in sensory cortex is modulated by behavioral and cognitive factors, and this modulation is thought to contribute to the selection of specific sensory information needed to achieve beha...
RORγt-expressing dendritic cells are functionally versatile and evolutionarily conserved antigen-presenting cells
Conventional dendritic cells (cDCs) are potent antigen-presenting cells (APCs) that integrate signals from their environment allowing them to direct situation-adapted immunity. Thereby they harbor gre...