Proceedings of the National Academy of Sciences
Articles in this Issue
Dnmt3a-mediated hypermethylation of FoxO3 promotes redox imbalance during osteoclastogenesis
Redox imbalance contributes to aberrant osteoclastogenesis and osteoporotic bone loss. In this study, we observed lower Forkhead box protein O3 (FoxO3), a transcription factor associated with cellular...
Polymorphic transposable elements contribute to variation in recombination landscapes
Meiotic recombination is a prominent force shaping genome evolution, and understanding why recombination rates vary within and between species has remained a central, though challenging, question. Var...
Cell–matrix feedback controls stretch-induced cellular memory and fibroblast activation
Mechanical stretch can activate long-lived changes in fibroblasts, increasing their contractility and initiating phenotypic transformations. This activation, critical to wound healing and procedures s...
Spiral spin liquid noise
An emerging concept for identification of different types of spin liquids [C. Broholm et al. , Science 367...
A splendid molecular factory: De- and reconstruction of the mammalian respiratory chain
Mitochondrial respiratory complexes I to IV and the F 1 F o -ATP synthase (complex V) are large protein assemblies produ...
Cryo-EM structures reveal the acetylation process of piccolo NuA4
NuA4 is the only essential acetyltransferase in yeast that can catalyze the acetylation of the histones H2A, H2A.Z, and H4, thereby affecting gene transcription. However, the acetylation process of Nu...
Deficiency in platelet 12-lipoxygenase exacerbates inflammation and disease severity during SARS-CoV-2 infection
Platelets, known for maintaining blood balance, also participate in antimicrobial defense. Upon severeacute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, platelets become hyperactivated,...
Epidemic evolutionarily stable strategies within an age-structured host population
To understand infectious disease dynamics, we need to understand the inextricably intertwined nature of the ecology and evolution of pathogens and hosts. Epidemiological dynamics of many infectious di...
Genomics highlight an underestimation of phenology sensitivity to the urban heat island effect
The phenological timing of leaf out in temperate forests is a critical transition point each year that alters the global climate system, which in turn, feeds back to plants, driving leaf out to occur...
<i>Staphylococcus aureus</i> uses a GGDEF protein to recruit diacylglycerol kinase to the membrane for lipid recycling
Staphylococcus aureus is a Gram-positive pathogen responsible for numerous antibiotic-resistant infections. Identifying vulnerabilities in S. aureus...
Conserved leucine-rich repeat proteins in the adhesive projectile slime of velvet worms
The slime of velvet worms (Onychophora) is a protein-based bioadhesive that undergoes rapid, yet reversible transition from a fluid into stiff fibers used for prey capture and defense, but the mechani...
Connectional axis of individual functional variability: Patterns, structural correlates, and relevance for development and cognition
The human cerebral cortex exhibits intricate interareal functional synchronization at the macroscale, with substantial individual variability in these functional connections. However, the spatial orga...
Reinforcement learning–based adaptive strategies for climate change adaptation: An application for coastal flood risk management
Conventional computational models of climate adaptation frameworks inadequately consider decision-makers’ capacity to learn, update, and improve decisions. Here, we investigate the potential of reinfo...
ACOD1-mediated lysosomal membrane permeabilization contributes to <i>Mycobacterium tuberculosis</i> –induced macrophage death
Mycobacterium tuberculosis (Mtb) primarily infects macrophages. In vitro without antibiotics, wild-type Mtb hastens death of the macrophages, but the processes leading to rapid cel...
Hair cell apoptosis and deafness in <i>Tmc1</i> mutations
Transmembrane channel-like protein 1 (TMC1), a pore-forming component of the mechano-electrical transducer (MET) channel in cochlear outer hair cells, is subject to numerous mutations causing deafness...
Functional morphology of gliding motility in benthic diatoms
Diatoms, a highly successful group of photosynthetic algae, contribute to a quarter of global primary production. Many species are motile, despite having no appendages and a completely rigid cell body...
Diversification, niche adaptation, and evolution of a candidate phylum thriving in the deep Critical Zone
The deep subsurface soil microbiome encompasses a vast amount of understudied phylogenetic diversity and metabolic novelty, and the metabolic capabilities and ecological roles of these communities rem...
Bringing pressure-induced superconductivity back to ambient pressure
Systemic signals control infection plasticity in parasitic plants
An atlas of early human mandibular endochondral and osteogenic paracrine signaling regions of Meckel’s cartilage
The mandible, also known as the lower jaw, is the only bone in the skull that can move and is essential for speaking and chewing. Meckel’s cartilage (MC) is a temporary structure that supports the for...
Archaeogenomic insights into commensalism and regional variation in pig management in Neolithic northwest Europe
The relationship between humans and pigs has changed dramatically since their domestication in southwest Asia and subsequent human-induced introduction into Europe. Introgression between incoming sout...
Electric spiking activity in epithelial cells
Epithelial cells (human keratinocyte cells and the canine MDCK cell line), traditionally viewed as electrically non-self-excitable and involved primarily in physiological functions such as barrier pre...
Maintaining cooperation through vertical communication of trust when removing sanctions
An effective way to foster cooperation is to monitor behavior and sanction freeriding. Yet, previous studies have shown that cooperation quickly declines when sanctioning mechanisms are removed. We te...
Agriculture’s impact on water–energy balance varies across climates
Agriculture is a cornerstone of global food production, accounting for a substantial portion of water withdrawals worldwide. As the world’s population grows, so does the demand for water in agricultur...
Iguanas rafted more than 8,000 km from North America to Fiji
Founder-event speciation can occur when one or more organisms colonize a distant, unoccupied area via long-distance dispersal, leading to the evolution of a new species lineage. Species radiations est...