Proceedings of the National Academy of Sciences
Articles in this Issue
Redox dye–mediated fluorescence energy transfer of carbon nanotube–based nanosensors
Single-walled carbon nanotubes (SWCNTs) exhibit nonphotobleaching, near-infrared (NIR) fluorescence suitable for bioimaging applications. In particular, SWCNT fluorescence quenching induced by biopoly...
ANGPTL3/8 is an atypical unfoldase that regulates intravascular lipolysis by catalyzing unfolding of lipoprotein lipase
Lipoprotein lipase (LPL) carries out the lipolytic processing of triglyceride-rich lipoproteins (TRL) along the luminal surface of capillaries. LPL activity is regulated by the angiopoietin-like prote...
Realizing a topological diode effect on the surface of a topological Kondo insulator
Introducing the concept of topology into material science has sparked a revolution from classic electronic and optoelectronic devices to topological quantum devices. The latter has potential for trans...
Uncovering bighorn sheep life-history trajectories in multidimensional trait space
Individual heterogeneity shapes ecoevolutionary processes at multiple scales. Yet, the scarcity of long-term life-history data and limitations in classic statistical tools hinder our capacity to uncov...
Highly spatial–temporal electrochemical profiling of molecules trafficking at a single mitochondrion in one living cell
Simultaneous profiling of multiple molecules trafficking at a single organelle and the surrounding cytosol within a living cell is crucial for elucidating their functions, necessitating advanced techn...
The PBAP chromatin remodeling complex mediates summer diapause via H3K4me3-driven juvenile hormone regulation in <i>Colaphellus bowringi</i>
Diapause, a developmental arrest mechanism, helps animals to survive seasonal changes via endocrine regulation. While obligate diapause is genetically programmed, facultative diapause is typically tri...
Trans-synaptic modulation of cholinergic circuits tunes opioid reinforcement
Opioids trigger structural and functional neural adaptations of the reward circuit that lead to dependence. Synaptic cell adhesion molecules (CAMs) play a pivotal role in circuit organization and pres...
Wdr5-mediated H3K4 methylation facilitates HSPC development via maintenance of genomic stability in zebrafish
During fetal stage, hematopoietic stem and progenitor cells (HSPCs) undergo rapid proliferation with a tight control of genomic stability. Although histone H3 lysine 4 (H3K4) methylation has been repo...
Correction for Xu et al., BCL6 promotes glioma and serves as a therapeutic target
Tumor immune evasion: Systemic immunosuppressive networks beyond the local microenvironment
MITD1 is a brain-specific interferon-inducible factor that inhibits flavivirus replication
West Nile virus (WNV) and Usutu virus (USUV) are closely related mosquito-borne neurotropic flaviviruses that share common transmission cycle and can infect humans. However, while human infections by...
Energy landscape analysis of the development of the chromosome structure across the cell cycle
During mitosis, there are significant structural changes in chromosomes. We used a maximum entropy approach to invert experimental Hi-C data to generate effective energy landscapes for chromosomal str...
<i>Chlamydomonas</i> FBB18 is a ubiquitin-like protein essential for the cytoplasmic preassembly of various ciliary dyneins
Motile cilia are organelles found on many eukaryotic cells that play critical roles in development and fertility. Human CFAP298 has been implicated in the transport/assembly of ciliary dyneins, and de...
Structural assembly of the PAS domain drives the catalytic activation of metazoan PASK
PAS domains are ubiquitous sensory modules that transduce environmental signals into cellular responses through tandem PAS folds and PAS-associated C-terminal (PAC) motifs. While this conserved archit...
Substrate recognition by a peptide-aminoacyl-tRNA ligase
The continuing discovery of new peptide-aminoacyl-tRNA ligases (PEARLs) has unveiled a diverse array of enzymes with the unique potential to append amino acids to the C terminus of substrate peptides...
Rippled metamaterials with scale-dependent tailorable elasticity
Thermally induced ripples are intrinsic features of nanometer-thick films, atomically thin materials, and cell membranes, significantly affecting their elastic properties. Despite decades of theoretic...
Molecular mechanisms underlying the evolution of a color polyphenism by genetic accommodation in the tobacco hornworm, <i>Manduca sexta</i>
How organisms evolve under extreme environmental changes is a critical question in the face of global climate change. Genetic accommodation is an evolutionary process by which natural selection acts o...
The origin of sulfur in Canary Island magmas and its implications for Earth’s deep sulfur cycle
The global sulfur cycle plays a critical role in the redox evolution of Earth’s surface and upper mantle, yet the distribution and origin of sulfur in the mantle remains largely unconstrained. El Hier...
Androgen receptors in corticotropin-releasing hormone neurons mediate the sexual dimorphism in restraint-induced thymic atrophy
Sexual dimorphism in immune responses is well documented, but the underlying mechanisms remain incompletely understood. Here, we identified a subset of corticotropin-releasing hormone (CRH) neurons th...
TAOK1 promotes filament formation in HR repair through phosphorylating USP7
Poly-ADP-ribose polymerase (PARP) inhibitors are vital therapeutic agents that exploit synthetic lethality, particularly effective in tumors with homologous recombination (HR) defects. However, broade...
Comprehensive mutant chemotyping reveals embedding of a lineage-specific biosynthetic gene cluster in wider plant metabolism
Plants produce diverse specialized metabolites with important ecological functions. It has recently become apparent that the genes for many of these pathways are not dispersed in plant genomes, but ra...
Entropy is an important design principle in the photosystem II supercomplex
Photosystem II (PSII) can achieve near-unity quantum efficiency of light harvesting in ideal conditions and can dissipate excess light energy as heat to prevent the formation of reactive oxygen specie...
The file drawer problem in social science survey experiments
The file drawer problem—often operationalized in terms of statistically significant results being published and statistically insignificant not being published—is widely documented in the social scien...
John Brauman (1937–2024): Physical organic chemist, sage, and servant of science
Hardware-optimal quantum algorithms
Quantum hardware is inherently fragile and noisy. We find that the accuracy of traditional quantum error correction algorithms can be improved depending on the hardware. Given different hardware speci...