Proceedings of the National Academy of Sciences
Articles in this Issue
Validating new limits for human thermoregulation
Recent projections suggest that large geographical areas will soon experience heat and humidity exceeding limits for human thermoregulation. The survivability limits modeled in that research were base...
Reconciling ecology and evolutionary game theory or “When not to think cooperation”
Evolutionary game theory (EGT)—overwhelmingly employed today for the study of cooperation in various systems, from microbes to cancer and from insect to human societies—started with the seminal 1973 p...
Removing masculine defaults in the hiring process
Onboard recordings reveal how bats maneuver under severe acoustic interference
Echolocating bats rely on active acoustic sensing to perceive their environment. When multiple bats fly together, echolocating simultaneously, the calls emitted by nearby conspecifics could interfere...
Microparticle impact–induced bond strength in metals peaks with velocity
Supersonic impact of metallic microparticles onto metallic substrates generates extreme interfacial deformation and high contact pressures, enabling solid-state metallic bonding. Although higher impac...
Biphasic mechanochemistry of single-chain polymerization
Mechanical forces can induce chemical reactions, produce chemical signals, and alter reaction kinetics. Here, using magnetic tweezers–based single-molecule force spectroscopy, we study the force effec...
Bilateral astrocyte reaction to unilateral insult in the optic projection to the brain
Anatomy of a range contraction: Flow–phenology mismatches threaten salmonid fishes near their trailing edge
Climate change is redistributing life on Earth, with profound impacts for ecosystems and human well-being. While repeat surveys separated by multidecadal intervals can determine whether observed shift...
A mechanically resilient soft hydrogel improves drug delivery for treating post-traumatic osteoarthritis in physically active joints
Intra-articular delivery of disease-modifying osteoarthritis drugs (DMOADs) is likely to be most effective in the early stages of post-traumatic osteoarthritis (PTOA), when symptoms are minimal, and p...
Peto’s paradox revisited (revisited, revisited, revisited, and revisited yet again)
Cotranslational membrane insertion of the voltage-sensitive K <sup>+</sup> channel KvAP
Voltage-sensor domains (VSDs), found in many voltage-sensitive ion channels and enzymes, are composed of four transmembrane helices (TMHs), including the atypical, highly positively charged S4 helix....
Single cell–resolved cellular, transcriptional, and epigenetic changes in mouse T cell populations linked to age-associated immune decline
Splenic T cells are pivotal to the immune system, yet their function deteriorates with age. To elucidate the specific aspects of T cell biology affected by aging, we conducted a comprehensive multi–ti...
Quirks of cognition explain why we dramatically overestimate the size of minority groups
Americans dramatically overestimate the size of African American, Latino, Muslim, Asian, Jewish, immigrant, and LGBTQ populations, leading to concerns about downstream racial attitudes and policy pref...
The rising income gradient in life expectancy in Sweden over six decades
This study examines the long-term association between income and life expectancy in Sweden between 1960 and 2021. The study is based on register data that include all Swedish permanent residents aged...
Therapeutic targeting of the NOTCH1 and neddylation pathways in T cell acute lymphoblastic leukemia
Gamma Secretase Inhibitors (GSIs) effectively block oncogenic Notch homolog-1 (NOTCH1), a characteristic feature of T cell acute lymphoblastic leukemias (T-ALL). However, their clinical application ha...
Cryo-EM structure of cyanopodophage A4 reveals a pentameric pre-ejectosome in the double-stabilized capsid
Upon infection, the podophages usually eject a couple of proteins from the capsid to form a transmembrane ejectosome on the host cell membrane that facilitates the ejection of viral genome. However, i...
Optogenetic stimulation of the dorsal striatum bidirectionally controls seizures
Despite a century of development of antiseizure medications, up to a third of people with epilepsy do not achieve seizure freedom with drug therapy. Deep brain stimulation is of growing use, but just...
Demographic interactions between the last hunter-gatherers and the first farmers
Demographic interaction processes play a pivotal role during episodes of cultural diffusion between different populations, particularly when these episodes can lead to competition for the same resourc...
Painting rich six-dimensional pictures using polarized fluorescence microscopy
Quina lithic technology indicates diverse Late Pleistocene human dynamics in East Asia
The Late Pleistocene of Eurasia is key for understanding interactions between early modern humans and different types of archaic human groups. During this period, lithic technology shows more diversit...