Proceedings of the National Academy of Sciences
Articles in this Issue
Rolling two-dimensional covalent organic framework (COF) sheets into one-dimensional electronic and proton-conductive nanotubes
Mimicking the interconvertible carbon allotropes of 2-dimensional (2D) graphene and 1-dimensional (1D) carbon nanotubes (CNTs), herein we report the in situ transformation of 2D π-conjugated covalent...
Is killing animals an effective way to regulate populations?
Regulatory mimicry of cyclin-dependent kinases by a conserved herpesvirus protein kinase
Herpesviruses encode conserved protein kinases (CHPKs) that target cellular cyclin-dependent kinase (CDK) phosphorylation sites; thus, they are termed viral CDK-like kinases. Tyrosine 15 in the GxGxxG...
In the flow, how fluid dynamics shapes amyloid formation
Steeper social discounting after human basolateral amygdala damage
Translational research suggests that the basolateral part of the amygdala (BLA) computes some of the core processes underlying social preferences, but its precise role in prosocial choice remains uncl...
Correction to Supporting Information for Nishiguchi et al., Vortex reversal is a precursor of confined bacterial turbulence
Sex chromosome evolution in haploid plants: Microchromosomes, disappearing chromosomes, and giant chromosomes
As in many diploid organisms with genetic sex determination, haploid-dominant organisms have also evolved sex chromosomes or extensive genomic regions that lack genetic recombination. An understanding...
Generating the polymorph landscapes of amyloid fibrils using AI: RibbonFold
The concept that proteins are selected to fold into a well-defined native state has been effectively addressed within the framework of energy landscapes, underpinning the recent successes of structure...
CD70 recruitment to the immunological synapse is dependent on CD20 in B cells
CD20 is a four-transmembrane protein expressed at the surface of B cells from late pro-B cells to memory B cells, with the exception of plasma cells. Its expression pattern makes it an attractive ther...
Protein Phosphatase 1 Regulatory Subunit 3C integrates cholesterol metabolism and isocitrate dehydrogenase in chondrocytes and neoplasia
Enchondromas are common bone tumors composed of chondrocytes originating from growth plate cells which can progress to malignant chondrosarcoma. Mutations in the genes encoding isocitrate dehydrogenas...
The evolution of robustness and fragility during long-term bacterial adaptation
Theory predicts that well-adapted populations may evolve mechanisms to counteract the inevitable influx of deleterious mutations. While mutational robustness can be directly selected in the laboratory...
Genomic signatures associated with the evolutionary loss of egg yolk in parasitoid wasps
Trait regression and loss have occurred repeatedly in numerous lineages in response to environmental changes. In parasitoid wasps, a megadiverse group of hymenopteran insects, yolk protein reduction o...
The Q226L mutation can convert a highly pathogenic H5 2.3.4.4e virus to bind human-type receptors
H5Nx viruses continue to wreak havoc in avian and mammalian species worldwide. The virus distinguishes itself by the ability to replicate to high titers and transmit efficiently in a wide variety of h...
Mechanism of allosteric activation in human mitochondrial ClpP protease
Human ClpP protease contributes to mitochondrial protein quality control by degrading misfolded proteins. ClpP is overexpressed in cancers such as acute myeloid leukemia (AML), where its inhibition le...
Iconicity as an organizing principle of the lexicon
The view that words are arbitrary is a foundational assumption about language, used to set human languages apart from nonhuman communication. We present here a study of the alignment between the seman...
European Neolithic farmers interbred their domestic pigs with wild boar
The multifaceted roles of the transcriptional coactivator TAZ in extravillous trophoblast development of the human placenta
Insights into the molecular processes that drive early development of the human placenta is crucial for our understanding of pregnancy complications such as preeclampsia and fetal growth restriction,...
A rare variant in <i>GPR156</i> associated with depression in a Mennonite pedigree causes habenula hyperactivity and stress sensitivity in mice
Major depressive disorder (MDD) is a leading cause of disability worldwide. Risk for MDD is heritable, and the genetic structure of founder populations enables investigation of rare susceptibility all...
Temperature thresholds induce abrupt shifts in biodiversity and ecosystem services in montane ecosystems worldwide
Montane ecosystems are crucial for maintaining global biodiversity and function that sustain life on our planet. Yet, these ecosystems are highly vulnerable to changing temperatures and may undergo cr...
SNX10 deficiency impairs sensitivity to anti-HER2 antibody–drug conjugates via altering HER2 trafficking in HER2-positive breast cancer
Antibody–drug conjugates (ADCs) are a rapidly developing therapeutic approach in cancer treatment that has shown remarkable efficacy in breast cancer. Despite the promising efficacy of anti-HER2 ADCs,...
Design principles for self-organization of mitotic spindle bipolarity
Tearing down the house of mosquito-transmitted viruses
Introducing the Special Feature on housing differences and inequality over the very long term
Molecular design of a therapeutic LSD analogue with reduced hallucinogenic potential
Decreased dendritic spine density in the cortex is a key pathological feature of neuropsychiatric diseases including depression, addiction, and schizophrenia (SCZ). Psychedelics possess a remarkable a...
A plant CLE peptide and its fungal mimic promote arbuscular mycorrhizal symbiosis via CRN-mediated ROS suppression
CLAVATA3/EMBRYO SURROUNDING REGION-related (CLE) peptides have emerged as key regulators of plant–microbe interactions, including arbuscular mycorrhizal (AM) symbiosis. Here, we identify...