Proceedings of the National Academy of Sciences
Articles in this Issue
Correction for Garaizar et al., Toward understanding lipid reorganization in RNA lipid nanoparticles in acidic environments
CD83 suppresses endogenous March-I-dependent MHC class II ubiquitination, endocytosis, and degradation
MHC class II glycoproteins (MHC-II) bind peptides derived from exogenous antigens and dendritic cells (DCs) present these peptide MHC-II (pMHC-II) complexes to antigen-specific CD4 T cells during immu...
Correction for Christos et al., A model of <i>d</i> -wave superconductivity, antiferromagnetism, and charge order on the square lattice
Mechanisms of photoreceptor protection upon targeting the <i>Nrl–Nr2e3</i> pathway
Acute knockout of the rod photoreceptor transcription factor Nrl delays retinal degeneration in multiple mouse models of blindness, but the downstream transcrip...
Where do fish go and why? For many species, nobody knows
Inhibiting 15-PGDH blocks blood–brain barrier deterioration and protects mice from Alzheimer’s disease and traumatic brain injury
Alzheimer’s disease (AD) and traumatic brain injury (TBI) are currently untreatable neurodegenerative disorders afflicting millions of people worldwide. These conditions are pathologically related, an...
Activation dynamics of ubiquitin-specific protease 7
Ubiquitin-specific protease 7 (USP7) is a deubiquitinating enzyme that plays a crucial role in cellular processes, including the maintenance of genome stability and regulation of antiviral and immune...
A direct computational assessment of vinculin–actin unbinding kinetics reveals catch-bonding behavior
Vinculin forms a catch bond with the cytoskeletal polymer actin, displaying an increased bond lifetime upon force application. Notably, this behavior depends on the direction of the applied force, whi...
Nonenzymatic RNA copying with a potentially primordial genetic alphabet
Nonenzymatic RNA copying is thought to have been responsible for the replication of genetic information during the origin of life. However, chemical copying with the canonical nucleotides (A, U, G, an...
Engineering spin coherence in core-shell diamond nanocrystals
Fluorescent diamond nanocrystals can host spin qubit sensors capable of probing the physical properties of biological systems with nanoscale spatial resolution. Sub-100 nm diamond nanosensors can read...
Correction for Eggertsen et al., Logic-based machine learning predicts how escitalopram attenuates cardiomyocyte hypertrophy
Trait-space patterning is dictated by the tempo and mode of mutation
In large, natural ecosystems, many ( ≳ 1) phenotypically relevant mutants can emerge over the characteristic turnover time of the population. When this is the c...
Partner dependency alters patterns of coevolutionary selection in mutualisms
Coevolution is a ubiquitous driver of diversification in both mutualistic and antagonistic interactions between species. In mutualisms, coevolution can result in trait complementarity between partners...
Macrophages release neuraminidase and cleaved calreticulin for programmed cell removal
Calreticulin (CALR) is primarily an endoplasmic reticulum chaperone protein that also plays a key role in facilitating programmed cell removal (PrCR) by acting as an “eat-me” signal for macrophages, d...
Calcineurin controls the cytokinesis machinery during thermal stress in <i>Cryptococcus deneoformans</i>
Calcineurin is a highly conserved phosphatase that plays a central role in sensing calcium and governing transcriptional, posttranscriptional, and posttranslational signaling networks. Calcineurin is...
Galvanotactic directionality of cell groups depends on group size
Motile cells migrate directionally in the electric field (EF) in a process known as galvanotaxis, an important phenomenon in wound healing and development. We previously reported that individual fish...
Phase separation of RXRγ drives tumor chemoresistance and represents a therapeutic target for small-cell lung cancer
Small-cell lung cancer (SCLC) is the most lethal type of lung cancer, characterized by rapid evolution from chemosensitivity to chemoresistance and limited treatment options. However, the mechanisms u...
The evolution of thermal performance curves in response to rising temperatures across the model genus yeast
The maintenance of biodiversity crucially depends on the evolutionary potential of populations to adapt to environmental change. Accelerating climate change and extreme temperature events urge us to b...
Effective polarization in potassium channel simulations: Ion conductance, occupancy, voltage response, and selectivity
Potassium (K + ) channels are widely distributed in many types of organisms. They combine high efficiency (~100 pS) and K +...
Knowledge of politician stock trading reduces congressional legitimacy and compliance with the law
Institutional legitimacy is essential for democracies, yet public trust and confidence in the United States Congress are at an all-time low. A significant predictor of attitudes toward Congress is per...
Ancient DNA suggests a historical demographic decline and genetic erosion in the Atlantic bluefin tuna
Overexploitation has depleted fish stocks during the past century; nonetheless, its genomic consequences remain poorly understood for most species. Characterizing the spatiotemporal patterns of these...
Can AI weather models predict out-of-distribution gray swan tropical cyclones?
Predicting gray swan weather extremes, which are possible but so rare that they are absent from the training dataset, is a major concern for AI weather models and long-term climate emulators. An impor...
Forecasting range shifts of dioecious plants under climate change
Global climate change has triggered an urgent need for predicting the reorganization of Earth’s biodiversity. For dioecious species (those with separate sexes), it is unclear how commonly unique clima...
Inflammatory cytokine upd3 induces axon length–dependent synapse removal by glia
Many neurodegenerative disorders (NDDs) preferentially affect neurons with long or complex axonal arbors but the cellular and molecular bases for neurite length-dependent vulnerability of neurons to d...
Arteries are finely tuned thermosensors regulating myogenic tone and blood flow
In response to changing blood pressure, arteries adjust their caliber to control blood flow. This vital autoregulatory property, termed vascular myogenic tone, stabilizes downstream capillary pressure...