Proceedings of the National Academy of Sciences
Articles in this Issue
Alternative cGAS signaling promotes herpes simplex encephalitis
During infection, foreign DNA is sensed by cyclic GMP-AMP synthase (cGAS) leading to the production of cGAMP, STING-dependent type I interferon and proinflammatory cytokine expression, and autophagy....
Dynamic early recruitment of GAK–Hsc70 regulates coated pit maturation
Clathrin-mediated endocytosis (CME) begins with the assembly of clathrin onto the plasma membrane. These structures grow and stabilize to form clathrin-coated pits (CCPs), which invaginate and accumul...
Evolution of the essential gene <i>MN1</i> during the macroevolutionary transition toward patterning the vertebrate hindbrain
The tight link between brain and skull formation is a fundamental aspect of vertebrate evolution and embryogenesis. Their developmental synchronization is essential for structural and functional integ...
The cellular dance that splits vessels
Modulation of human dorsal root ganglion neuron firing by the Nav1.8 inhibitor suzetrigine
Nav1.8 voltage-gated sodium channels are strongly expressed in human primary pain-sensing neurons (nociceptors) and a selective Nav1.8 inhibitor VX-548 (suzetrigine) has shown efficacy for treating ac...
Longitudinal associations between birth-to-six cortical growth and childhood neurocognitive function
The human cortex undergoes immense change in the first years of life, doubling in thickness within the first year and evidencing the greatest change within the first 5 y. While substantial research ha...
Reply to Siqueira-Batista and Gómez: Underscoring the importance of biosafety for the return of Martian samples
Formation of giant ER sheets by pentadecanoic acid causes lipotoxicity in fission yeast
Excess amounts of saturated fatty acids (FAs) are toxic to organisms, a condition termed lipotoxicity, which is often accompanied by pleiotropic cellular and tissue dysfunction. Here, we show that pen...
Toward elucidating the mechanism of cochlear stimulation by infrared light
Synthesizing decades of research into one tree for birds
Self-reproduction as an autonomous process of growth and reorganization in fully abiotic, artificial and synthetic cells
We investigate mechanisms for the observed nonlinear growth in the number of polymer vesicles generated during a photo-Reversible Addition-Fragmentation Chain Transfer-based polymerization-induced sel...
Martian samples, hazards, and biosecurity: Between science and bioethics
High-affinity detection of biotinylated endogenous neuroligin-1 at excitatory and inhibitory synapses using a tagged knock-in mouse
Neuroligins (NLGNs) are important cell adhesion molecules mediating trans-synaptic contacts between neurons. However, the high-yield biochemical isolation and visualization of endogenous NLGNs is hamp...
Two endogenous <i>Dictyostelium discoideum</i> chemorepellents use different mechanisms to induce repulsion
The directed movement of eukaryotic cells is critical for processes such as development and immune responses. While much is known about chemoattraction, much less is known about chemorepulsion. The eu...
The IL-18 receptor is expressed on murine small-intestinal enterochromaffin cells and executes a recovery program upon injury
Upon injury, epithelial-derived IL-18 is released and induces an inflammatory response in underlying IL18R1 + lamina propria cells. Notably,...
Stimulus representations in visual cortex shaped by spatial attention and microsaccades
Microsaccades (MSs) are commonly associated with covert spatial attention, yet their impact on cortical processing of visual objects remains unclear. Rhesus macaques, randomly cued to attend to a targ...
A viral necrosome mediates direct RIPK3 activation to promote inflammatory necroptosis
Necroptosis is an inflammatory programmed cell death pathway triggered by RIPK3 activation through one of the upstream RHIM-domain-containing proteins including RIPK1, TRIF, and ZBP1. Whether necropto...
A whole-scale volatile-depleted lunar interior
The extent of moderately volatile elements (MVE) depletion and its effects on the Moon’s evolutionary history remain contentious, partly due to unintentionally biased sampling by the Apollo missions f...
Mgat4b-mediated selective <i>N</i> -glycosylation regulates melanocyte development and melanoma progression
Melanocyte development involves key pathways that are often recapitulated during melanoma initiation, highlighting the importance of understanding these regulatory processes. Our study identifies...