Proceedings of the National Academy of Sciences
Articles in this Issue
A common denominator: PTSD, rapid eye movements, and fear extinction
Infrared spectroscopy–based zero-shot learning for identifying reaction intermediates in unseen systems
Identifying reaction intermediates is a critical component of elucidating the mechanisms of chemical reactions. Spectroscopic techniques are instrumental in this identification process. The capacity o...
Logarithmic kinetics and bundling in random packings of elongated 3D physical links
We explore the impact of excluded volume interactions on the local assembly of linear physical networks, where nodes are spheres and links are rigid cylinders with varying length. To focus on the effe...
Influenza A virus NS1 protein mimics oncogenic PI3K resulting in isoform specific cellular redistribution and activation
The nonstructural protein 1 (NS1) of influenza A virus performs a broad variety of proviral activities in the infected cell, primarily mediating evasion from the host innate immune response by being t...
Structural basis for anaerobic alkane activation by a multisubunit glycyl radical enzyme
X-succinate synthases (XSSs) are glycyl radical enzymes (GREs) that catalyze the addition of hydrocarbons to fumarate via radical chemistry, thereby activating them for microbial metabolism. To date,...
Anisotropic stretch biases the self-organization of actin fibers in multicellular Hydra aggregates
During development, groups of cells generate shape by coordinating their mechanical properties through an interplay of self-organization and prepatterning. Hydra displays a striking planar pattern of...
Toward a molecular logic of lipid droplet heterogeneity?
Derailed degradation: LRRK2-dependent exocytosis in Parkinson’s disease
The entities enabling scientific fraud at scale are large, resilient, and growing rapidly
Science is characterized by collaboration and cooperation, but also by uncertainty, competition, and inequality. While there has always been some concern that these pressures may compel some to defect...
Protective antigen–mediated delivery of an anti-CRISPR protein for precision genome editing
Precise control over the dosage of Cas9-based technologies is essential because off-target effects, mosaicism, chromosomal aberrations, immunogenicity, and genotoxicity can arise with prolonged Cas9 a...
Cryptic intronic transcriptional initiation generates efficient endogenous mRNA templates for C9orf72-associated RAN translation
Intronic GGGGCC hexanucleotide repeat expansions in C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia...
Progressively greater biological carbon storage in the deep Atlantic during glacial inception
Changes in oceanic circulation and carbon storage have been implicated as important drivers of atmospheric pCO 2 variability during the last glacial cycle (0 to...
Pelota-mediated ribosome-associated quality control counteracts aging and age-associated pathologies across species
Ribosome-associated quality control (RQC) is a pivotal biological process that governs the fidelity of messenger RNA (mRNA) homeostasis and protein synthesis. Defects in RQC are implicated in cellular...
Immune-responsive gene 1: The mitochondrial key to Th17 cell pathogenicity in CNS autoimmunity
Pathogenic Th17 cells play crucial roles in CNS autoimmune diseases such as multiple sclerosis (MS), but their regulation by endogenous mechanisms remains unknown. Through RNA-seq analysis of primary...
Retraction for Martinez et al., Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells
Eliminating hunger in a world serious about climate mitigation
What will it take to eliminate hunger in a world that is increasingly serious about climate change mitigation? For the past two decades, climate activism and mitigation efforts have largely focused on...
Rapid, interpretable data-driven models of neural dynamics using recurrent mechanistic models
Obtaining predictive models of a neural system is notoriously challenging. Detailed models suffer from excess model complexity and are difficult to fit efficiently. Simplified models must negotiate a...
A recurrent de novo damaging variant in <i>EMP2</i> causes progressive symmetric erythrokeratoderma
Genetic investigation in Mendelian skin disorders featuring generalized or localized skin scaling and redness, known as the ichthyoses, has revealed novel pathways relevant to epidermal integrity, bar...
A genomic test of sex-biased dispersal in white sharks
Mitonuclear discordance has been observed in several shark species. Female philopatry has often been invoked to explain such discordance but has never been explicitly tested. Here, we focus on the whi...
The activity and expression of adenylosuccinate lyase were reduced during modern human evolution, affecting brain and behavior
Adenylosuccinate lyase (ADSL), an enzyme that is crucial for purine biosynthesis, carries an amino acid substitution that is present in almost all humans today but absent in Neandertals and Denisovans...
Prevalence of monogamy at the level of flowers in plants
Different types of genomic conflicts are possible in plants with multiovulate ovaries that produce multiseeded fruits: between the maternal plant and its offspring, among developing seeds, between pat...
Tree rings reveal persistent Western Apache (Ndee) fire stewardship and niche construction in the American Southwest
Identifying the influence of low-density Indigenous populations in paleofire records has been methodologically challenging. In the Southwest United States, well-replicated fire histories suggest that...
Confined colloidal droplets dry to form circular mazes
During drying, particle-laden sessile droplets will leave so-called coffee-stain rings behind. This phenomenon is well known and well understood (Deegan et al ....
Reinstating memories’ temporal context at encoding causes Sisyphus-like memory rejuvenation
As memories age, their immediate retrievability decreases albeit, due to ongoing memory consolidation, their future rate of forgetting weakens. Here, we show in two experiments ( N...