Proceedings of the National Academy of Sciences
Articles in this Issue
De novo design of potent inhibitors of clostridial family toxins
Clostridioides difficile remains a leading cause of hospital-acquired infections, with its primary virulence factor, toxin B (TcdB), responsible for severe colitis and recurrent di...
PPT1 is a negative regulator of STING signaling in cancer cells and its inhibition reactivates immune surveillance in cold tumors
Immunotherapy modalities have revolutionized cancer treatment for a number of metastatic and treatment-refractory tumor types. Still, many malignancies that lack T cell infiltration and are termed imm...
The discovery of adzuki bean ( <i>Vigna angularis</i> ) in eastern China during the 9th millennium BP and its domestication in East Asia
Adzuki bean ( Vigna angularis ) is a key legume widely cultivated in East Asia, prized for both its nutritional value and nitrogen-fixing properties. This paper...
VOC injection into a house reveals large surface reservoir sizes in an indoor environment
The total partitioning capacity of indoor surface reservoirs determines the mechanism by which humans receive nondietary exposure to organic contaminants, via inhalation, dermal uptake, and dust inges...
Triple checkpoint blockade of PD-1, Tim-3, and Lag-3 enhances adoptive T cell immunotherapy in a mouse model of ovarian cancer
The five-year survival rate for ovarian cancer patients remains below 50%, underscoring the need for innovative therapies. One promising approach involves engineering T cells to specifically target pr...
Characterization of exoplanets in the James Webb Space Telescope era
Motor expertise modulates cortical activation during imagery of simple and complex actions
Motor imagery (MI) engages neural systems that overlap with actual movement and is widely used in sport and rehabilitation. Yet conflicting findings suggest that experts show either reduced (neural ef...
A first look at rocky exoplanets with JWST
Rocky exoplanet characterization has been a top priority for early James Webb Space Telescope (JWST) science operations. Several milestones have been achieved, including the most precise rocky planet...
Software-Enhanced Drugs™: The third platform reshaping drug development
Strategic planning of prevention and surveillance for emerging diseases and invasive species
Emerging infectious diseases and biological invasions pose increasing threats to public and ecosystems health. Proactive measures—such as prevention and surveillance taken before initial detection of...
Incentivizing teamwork to promote sustainability
There are a variety of contexts in which “pitching in” to address environmental or resource management problems could benefit from individuals or firms working not just on their own but also working t...
Reply to Fleming: Not a gossamer web
Counterfactual history
The potential impacts of human genetics on virus emergence
Human monogenic traits can confer resistance to viral infection in exposed individuals or predisposition to severe disease in infected individuals. Enhanced susceptibility can be driven directly by mu...
Reply to Lakhan and Wicks: Placement of drug–software combinations within VISTA’s platform taxonomy
Action painting under spectroscopic light: Excited-state exchange interactions behind the vibrant blue in Jackson Pollock’s <i>Number 1A, 1948</i>
Number 1A, 1948 by Jackson Pollock is a quintessential example of his action painting technique where ropes of color, drips of black, and pools of white coalesce into the layered d...
IFN-inducible human phospholipid scramblase 1 (PLSCR1) protein restricts HIV-1 infection by inhibiting membrane fusion
Human phospholipid scramblase 1 (PLSCR1) is an interferon-stimulated gene (ISG) that inhibits viral infections through various mechanisms. Here, we identify PLSCR1 as a host restriction factor that in...
Oxytocin and vasopressin enhance social pain empathy via common and distinct of neural expressions, genetic pathways, and networks
Witnessing social distress of others evokes social pain empathy, a complex process engaging cognitive, affective, and motivational dimensions. Although hypothalamic neuropeptides oxytocin (OXT) and ar...
Versatile <i>Xenopus tropicalis</i> model with targeted integration of human <i> BRAF <sup>V600E</sup> </i>
Targeting exogenous gene integrations in animals often exhibits low efficiency, limiting the development of gene knock-in models. Theoretically, by screening founder generation individuals based on th...
RNA triple helix assembled by the poly(A) tail enhances retrotransposon mobilization by preventing RNA deadenylation
Transposable elements (TEs), ubiquitous mobile DNAs, are largely repressed by cellular mechanisms such as epigenetic silencing and RNA decay, yet some retain the ability to transpose. The...
Nav1.8: Intrinsic limits on the functional effect of abrogation in DRG neurons
Voltage-gated sodium channel Nav1.8 plays a crucial role in regulating excitability of small dorsal root ganglion (DRG) neurons and is an emerging target for pain therapeutics. Using dynamic clamp, we...
A <i>Campylobacter jejuni</i> sensor phosphatase–driven two-component system integrates metabolic phosphodonors as cues in signal transduction
Canonical bacterial two-component signal transduction systems (TCSs) detect cues by sensors with opposing kinase and phosphatase activities to alter the level of phosphorylation of cognate response re...
Fast calculation of small-angle scattering profiles of dense protein solutions modeled at the all-atom level
The small-angle scattering (SAS) profile of a dense protein solution contains rich information about interprotein interactions, but extracting this information has been extremely challenging. In previ...
The genome of the vining fern <i>Lygodium microphyllum</i> highlights genomic and functional differences between life phases of an invasive plant
Functional and genomic studies on the differences between the gametophyte and sporophyte life phases of plants remain scarce, yet unraveling these dynamics is crucial to understanding the biology of p...
A diverse family of bacterial deubiquitinases is defined by the <i>Coxiella burnetii</i> effector EmcB
The obligate intracellular pathogen Coxiella burnetii encodes a deubiquitinase called EmcB that prevents signaling by the host immune sensor Retinoic acid Induc...