Proceedings of the National Academy of Sciences
Articles in this Issue
Evolution under vancomycin selection drives divergent collateral sensitivity patterns in <i>Staphylococcus aureus</i>
Staphylococcus aureus bacteremia is typically treated empirically with vancomycin, with therapy later tailored based on susceptibility results. However, these tests occur before va...
Nonmuscle myosin 2 turnover in cells is synergistically controlled by the tail and the motor domain
Myosin 2, an actin-dependent motor, is universally responsible for cell contractility due to its ability to form bipolar filaments. Fast turnover of nonmuscle myosin 2 (NM2) filaments is necessary to...
FGF21 acting on the noradrenergic nervous system protects against influenza virus infection
The hormone fibroblast growth factor 21 (FGF21) is induced in murine liver in response to both bacterial and viral infection. In this report, we show that FGF21 is induced by infection with influenza...
Structural insights into the dynamic mechanism of bornavirus polymerase
Borna disease virus 1 (BoDV-1), an emerging zoonotic pathogen from the Bornaviridae family, is neurotropic and can infect a variety of mammalian hosts, includin...
Duplication of a conserved mitochondrial enzyme gene arms parasitoid wasps with venom cytotoxicity and oogenesis regulation
Gene duplication, followed by neofunctionalization, is a key mechanism driving the emergence of evolutionary novelties. Despite its significance, the molecular and functional processes underlying this...
When neighbors play a role: A systems-level analysis of protein interactions conditioning cancer driver mutation effects
Cancer is driven by the accumulation of somatic mutations, including driver mutations that confer a selective advantage to cancer cells. Driver proteins operate within complex interaction networks, an...
An unusual Co–S bond links B <sub>12</sub> chaperones in an interprotein complex
Chaperones in trafficking pathways ensure specificity of transition metal loading and protection against adventitious side reactions. In B 12 , an essential cof...
Novelty as a drive of human exploration in complex stochastic environments
In order to find extrinsic rewards, humans explore their environment even if exploration requires several intermediate, reward-free decisions. It has been hypothesized that intrinsic rewards, such as...
Glycan microarray analysis of <i>Candida</i> -related antibodies in human and mice sera guides biomarker discovery and vaccine development
Invasive, high-mortality yeast infections caused by pathogenic Candida species are the most common fungal nosocomial bloodstream infections. The World Health Or...
Correction for Wang et al., Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility
SARS-CoV-2-derived RNA replicons as safe and effective vaccines
A collection of RNA replicons (RRs) derived from severe acute respiratory syndrome 2 (SARS-CoV-2) for use in vaccine design was constructed by genetic engineering using bacterial artificial chromosome...
Ectopic transcription due to inherited histone methylation may interfere with the ongoing function of differentiated neurons
How mutations in histone modifying enzymes lead to neurodevelopmental defects is unknown. To address this question, we took advantage of the invariant embryonic lineage and adult nervous system in...
<i>Inseparable/IER3IP1</i> are essential for cytokinesis in <i>Drosophila</i> neuroblasts and human cells
To unveil the molecular players that maintain neural stem cell (NSC) homeostasis, we conducted a genetic screen in Drosophila and isolated an uncharacterized ge...
Correction for Pederson, Étienne-Émile Baulieu (1929–2025): Scientist of steroids and champion of women’s reproductive rights
Anion–π interaction–induced phase separation as a prebiotic pathway to oxygenation
Compartmentalization and chemical reactivity serve as the key elements driving prebiotic chemistry for evolution and selection. However, the potential coupling of compartmentalization chemistry with t...
Intranasal hemagglutinin protein boosters induce protective mucosal immunity against influenza A viruses in mice
Licensed parenteral influenza vaccines induce systemic antibody responses and alleviate disease severity but do not efficiently induce local mucosal immune responses. Here, we describe an intranasal b...
Glycosylated cannabinoids in <i>Cannabis sativa</i> and enzyme design to modulate their synthesis
Despite extensive study of its chemical composition and long history of medicinal use, the occurrence of glycosylated cannabinoid derivatives in Cannabis sativa...
SARS-CoV-2 mutant spectrum complexity is an epidemiologically evolvable trait
RNA virus populations consist of complex and dynamic mutant spectra in which most individual genomes differ in one or more positions from the other genomes of the same population. This behavior, known...