Proceedings of the National Academy of Sciences
Articles in this Issue
Mineral dissolution by dimeric complexes
Mineral dissolution is typically thought to occur by the detachment of monomeric building blocks of the crystal structure, although direct evidence is rare. Using in situ high-speed atomic force micro...
Visualization of spin–orbit-entangled 4f electrons in crystalline materials
Lanthanide 4f electrons are strongly influenced by spin–orbit coupling, resulting in well-defined J multiplets, which are further split by the crystalline elect...
Generative AI for navigating synthesizable chemical space
We introduce SynFormer, a generative modeling framework designed to efficiently explore and navigate synthesizable chemical space. Unlike traditional molecular generation approaches, we generate synth...
The timeframe of prediction for eco-evolutionary dynamics
Generalized convolutional many-body distribution functional representations
Modern machine learning (ML) models of chemical and materials systems with billions of parameters require vast training datasets and considerable computational efforts. Lightweight kernel or decision...
Spatial self-organization of confined bacterial suspensions
Lab studies of bacteria usually focus on cells in spatially extended, nutrient-replete settings, such as in liquid cultures and on agar surfaces. By contrast, many biological and environmental setting...
Turning mass support for environmental goals into action
Taking evo-devo to the next level
Generative AI for computational chemistry: A roadmap to predicting emergent phenomena
The recent surge in generative AI has introduced exciting possibilities for computational chemistry. Generative AI methods have made significant progress in sampling molecular structures across chemic...
Single-cell lysis patterns morphogenesis of eDNA in the matrix of <i>Pseudomonas aeruginosa</i> biofilms
When bacteria form a biofilm, complex behaviors emerge. Biofilm bacteria differ from their free-living counterparts, exhibiting heterogenous, spatiotemporally patterned behavior. Can we explain these...
Supply–demand strategies for near-term climate benefits from hydrogen in the United States
Hydrogen (H 2 ) is a promising energy carrier for decarbonization. However, the greenhouse gas (GHG) mitigation potential of the H 2...
Inequality in air pollution–attributable mortality by income level between and within countries
Air pollution is a major global health threat, with exposure exhibiting substantial heterogeneity across and within regions. While disparities in air pollution exposure by income groups are well docum...
Evolutionary consideration of serial order processing by the normal rodent brain
The granular mid-dorsolateral prefrontal cortex of the primate brain is the final stage in the evolutionary development from the phylogenetically older agranular frontal cortex that lies above the ant...
Retraction for Safdar et al., Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice
Collagen-disrupting attIL12 TIL therapy boosts deep T cell infiltration via dual signaling activation and CCKAR reduction in sarcomas
Tumor-targeted T cell therapies of various types have been booming, but T cell therapy is limited by its inability to penetrate the collagen barrier surrounding tumors. The destruction of tumor collag...
A new era of understanding of the control of thick filament states in the heartbeat
A time-gated PKA–CREB signaling circuit licenses IL-12 responsiveness and Th1 fate in CD4 <sup>+</sup> T cells
Naïve CD4 + T cells differentiate into Th1 cells upon T-cell Receptor (TCR) stimulation in the presence of Interferon gamma (IFN-γ) and Interleukin 12 (IL-12)....
The principles behind equivariant neural networks for physics and chemistry
A distinguishing feature of the neural network models used in Physics and Chemistry is that they must obey basic underlying symmetries, such as symmetry to translations, rotations, and the exchange of...
Methanogenesis inhibition remodels microbial fermentation and stimulates acetogenesis in ruminants
Rumen microbiota enable ruminants to grow on fibrous plant materials, but also produce methane, driving 5% of global greenhouse gas emissions and leading to a loss of gross energy content. Methanogene...
Lattice distortion leads to glassy thermal transport in crystalline Cs <sub>3</sub> Bi <sub>2</sub> I <sub>6</sub> Cl <sub>3</sub>
The glassy thermal conductivities observed in crystalline inorganic perovskites such as Cs 3 Bi 2 I...
Total cancer risk estimates from measured concentrations of volatile organic compounds in industrialized southeastern Louisiana
Communities in southeastern Louisiana are subject to disproportionate environmental health burdens, including elevated risk for cancer, from emissions of industrial hazardous air pollutants (HAPs). Ho...
Unveiling ignis fatuus: Microlightning between microbubbles
Will-o’-the-wisps, ghostly blue flames seen at night in marshlands and long attributed to methane cool flames, have remained scientifically unexplained, a mystery caused by the lack of a known ignitio...
Chemical characterization of C <sub>31</sub> sterols from sponges and Neoproterozoic fossil sterane counterparts
Putative metazoan body fossils from the Precambrian are curiously lacking morphological characteristics that link them unambiguously to extant animal phyla, including sponges. Chemical fossils such as...
Nonuniform water distribution in Jupiter’s midlatitudes: Influence of precipitation and planetary rotation
Knowing the composition of Jupiter’s atmosphere is crucial for constraining Jupiter’s bulk metallicity and formation history. Yet, constraining Jupiter’s atmospheric water abundance is challenging due...