Proceedings of the National Academy of Sciences
Articles in this Issue
Correction for Bawa et al., Prevalence of monogamy at the level of flowers in plants
Intrinsically disordered linkers and terminal domains codrive aciniform spidroin self-assembly through liquid–liquid phase separation
Aciniform silk is a remarkably tough and elastic protein fiber primarily used by spiders to wrap prey and construct the inner layers of egg sacs. While the formation of ampullate and eggcase silks has...
Correction for Kolomenskiy et al., Scaling and mechanical optimality of bristled wings in microinsects
Correction for Quintero, The diffused evolutionary dynamics of morphological novelty
Reply to Koplenig and Wolfer: Global language analyses must account for relationships, location, and unbalanced binary data
Statistical physics of large-scale neural activity with loops
As experiments advance to record from tens of thousands of neurons, statistical physics provides a framework for understanding how collective activity emerges from networks of fine-scale correlations....
Functional genetic elements of a butterfly mimicry supergene
Development requires the coordinated action of many genes across space and time, yet numerous species can develop discrete, alternate phenotypes. Such complex balanced polymorphisms are often controll...
Transpupillary in vivo two-photon imaging reveals enhanced surveillance of retinal microglia in diabetic mice
The retina, located outside the cranium, serves as an ideal structure for investigating information processing within the central nervous system due to its well-organized neurovascular unit comprising...
Goblet cells dictate viral tropism and pathogenesis in nasal and intestinal mucosae
Host determinants are critical for shaping the outcomes of viral mucosal infections and developing effective antiviral strategies. However, the regulatory roles of “nonsusceptible” mucosal cells remai...
Predicting forced responses of probability distributions via the fluctuation–dissipation theorem and generative modeling
We present a flexible data-driven framework for estimating the response of higher-order moments of nonlinear stochastic systems to small external perturbations. The classical generalized fluctuation–d...
Multisensory electronic skin with decoupled pressure–temperature-sensing capabilities for similar object recognition
Multisensory electronic skin (e-skin), which mimics the tactile capabilities of human skin, is pivotal in equipping robots with intelligent perceptual functions. Despite numerous advances in multifunc...
Predicting the way forward for the Global Biodiversity Framework
A multilayered gap junction network is essential for social decision-making
Early-life social experiences can shape adult behavior, yet the underlying neural mechanisms of this plasticity remain incompletely understood. Here, we show that Caenorhabditis el...
The integrated stress response suppresses antiviral RNA interference by autophagy-mediated degradation of the RNA-induced silencing complex
The small interfering RNA (siRNA) pathway is a highly conserved antiviral defense mechanism in vertebrates and invertebrates. Although the core components of this pathway are well characterized, its u...
Disulfide cross-linked redox-sensitive peptide condensates are efficient cell delivery vehicles of molecular cargo
Biomolecular condensates (BCs) are phase-separated viscoelastic hubs within demixed solutions enriched in proteins and nucleic acids. Such condensates, also called membraneless organelles, are increas...
Regulation of an lncRNA <i>irf8</i> by the Ikzf1/Myb complex drives neutrophil development
As critical executors of the immune system, neutrophils provide an immediate inflammatory response for the clearance of debris and microbes, which is essential for the protection of health. Developmen...
A phosphoinositide-mediated switch of GET pathway receptor dimerization in <i>Arabidopsis</i>
The Guided Entry of Tail-Anchored Proteins (GET) pathway facilitates the insertion of tail-anchored (TA) proteins into the ER membrane, but its regulation in plants remains unclear. In...
5′-terminal glycosylation of protein-coding transcripts: An epitranscriptomic modification that prolongs mRNA lifetimes
Glycosylation is among the most common molecular modifications in living organisms, one that affects the function of myriad macromolecules: mostly proteins, lipids, and polysaccharides of various kind...
Search for a parity-violating long-range spin-dependent interaction
High-sensitivity quantum sensors are a promising tool for experimental searches for beyond-Standard-Model interactions. Here, we demonstrate an atomic comagnetometer operating under a resonantly-coupl...
Exceedingly low genetic diversity in snow leopards due to persistently small population size
Snow leopards ( Panthera uncia ) serve as an umbrella species whose conservation benefits their high-elevation Asian habitat. Their numbers are believed to be i...
Nanomedicines targeting protease-activated receptor 2 in endosomes provide sustained analgesia
Although many internalized G protein-coupled receptors (GPCRs) continue to signal, the mechanisms and outcomes of intracellular GPCR signaling are uncertain due to the challenges of measuring organell...
Gene age shapes functional and evolutionary properties of the <i>Drosophila</i> seminal fluid proteome
Seminal fluid proteins (Sfps) are crucial for animal reproductive success, with Sfp-encoding genes believed to be evolutionarily young due to heightened rates of gene loss and gain and rapidly evolvin...
The locus coeruleus maintains core body temperature and protects against hypothermia during dexmedetomidine-induced sedation
Activating the adra2a receptors of the brain’s norepinephrine (NE) system produces NREM-like sleep and hypothermia. Dexmedetomidine (DEX), a selective α2 recept...
Human deep sleep facilitates cerebrospinal fluid dynamics linked to spontaneous brain oscillations and neural events
How sleep maintains our healthy brain function has remained one of the biggest mysteries in neuroscience, medical settings, and daily lives. While cerebrospinal fluid (CSF) during sleep has been impli...
Human MX1 orchestrates the cytoplasmic sequestration of neosynthesized influenza A virus vRNPs
Interferon-inducible Myxovirus resistance 1 (MX1) proteins are known to restrict influenza A virus (IAV) transcription/replication process. Herein, we show that this early restriction was only partial...