Proceedings of the National Academy of Sciences
Articles in this Issue
PCNA is a nucleotide exchange factor for the clamp loader ATPase complex
All life requires loading ring-shaped sliding clamp protein complexes onto DNA. The sliding clamp loader is a conserved AAA+ ATPase that binds the sliding clamp, opens the ring, and places it onto DNA...
Andreev versus tunneling spectroscopy of unconventional flat-band superconductors
Andreev spectroscopy is one of the few phase-sensitive experiments done on moiré graphene superconductors (SC) that can shed light on the pairing symmetry. Its interpretation however is unclear, as Sc...
Correction for Dong et al., Hybridoma-inspired strategy crafts tailored multifunctional exosomes for precision therapy
Active nematic pumps
Microfluidics involves the manipulation of flows at the microscale, typically requiring external power sources to generate pressure gradients. Alternatively, harnessing flows from active fluids, which...
Correction for Ma et al., Intercellular propagation of RIPK1/RIPK3 amyloid fibrils
Detection of anyon braiding through pump–probe spectroscopy
We show that the braiding of anyons in a quantum spin liquid leaves a distinct dynamical signature in the nonlinear pump–probe response. Using a combination of exact diagonalization and matrix product...
Structure and encapsulation of carbonic anhydrase within the α-carboxysome
Carboxysomes in cyanobacteria and certain proteobacteria enable efficient CO 2 fixation by encapsulating ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisc...
Electrically driven first-order phase transition of a 2D ionic crystal at the electrode/electrolyte interface
Liquid electrolytes adsorbed at the surface of metallic electrodes display a multitude of structures that can largely differ from the parent bulk system, both in terms of composition and local organiz...
SERK5 genetically compensates for the loss of BAK1 and BKK1 in regulating elf18-triggered immune signaling in <i>Arabidopsis</i>
SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASEs (SERKs), particularly BRASSINOSTEROID INSENSITIVE1-ASSOCIATED KINASE 1 (BAK1) (SERK3) and BKK1 (SERK4), function as pleiotropic coreceptors to transduce ext...
Retraction for Murmu et al., Dynamic antagonism between RNA-binding protein CUGBP2 and cyclooxygenase-2-mediated prostaglandin E <sub>2</sub> in radiation damage
CASKIN2 mediates PTPσ-orchestrated transsynaptic mechanisms at excitatory synapses
Presynaptic active zones (AZs) perform essential functions in orchestrating speedy and accurate neurotransmission. Despite extensive studies on their molecular constituents, it remains unclear how tra...
Correction for Rigney et al., A vasopressin circuit that modulates mouse social investigation and anxiety-like behavior in a sex-specific manner
Wildfires have created instability within risk transfer markets. Here’s a path forward
Designing unique mechanical modes through an extension of the quantum hopping method
We extend the hopping method, traditionally used in condensed matter physics to calculate electron distribution in crystalline structures, to mechanical systems. This extension offers an efficient and...
Correction for Qiu et al., <i>miR444b.2</i> –HsfA1– <i>AOC1</i> module mediates heat priming–enhanced blast resistance in rice
Rewilding microbiology
Correction to Supporting Information for Giossi et al., Arkypallidal neurons in the external globus pallidus can mediate inhibitory control by altering competition in the striatum
The SWI/SNF chromatin-remodeling subunit DPF2 regulates macrophage inflammation in intestinal injury via the CACNA1D-mediated MAPK pathway
The immune system plays a pivotal role in pathogenesis of intestinal injury and subsequent regenerative processes, particularly macrophages, orchestrate the inflammatory response and tissue repair. He...
A unified framework for identification of cell-type-specific spatially variable genes in spatial transcriptomic studies
Characterizing cell-type-specific spatially variable genes (SVGs) within tissue context is essential for exploring the landscape of complex biological systems in spatial transcriptomic (ST) studies. I...
Time-of-day modulation in mosquito response persistence to carbon dioxide is controlled by Pigment-Dispersing Factor
Each year, hundreds of millions of people are sickened by diseases that are transmitted through mosquito bites, including dengue, Zika, and malaria. Mosquito biting does not occur uniformly throughout...
Angle dependence as a unifying feature of root graviresponse modules
Gravitropism, the patterning of postembryonic growth in relation to the gravity vector, allows plants to optimize the use of limited and nonhomogenous resources in their immediate environment. Since t...
MC1R determines healing outcomes in acute and chronic cutaneous wounds
Chronic wounds (CWs) represent a major clinical challenge, characterized by persistent inflammation and failed repair. While proresolving pathways are known to regulate inflammatory responses, their p...
METTL3-dependent m6A RNA methylation suppresses aberrant mammary epithelial differentiation and neoplastic transformation
The mechanisms underlying sustained proliferation and aberrant cellular plasticity that drive early breast tumorigenesis remain unclear. Using CRISPR knockout (KO) screens, we systematically character...
FZD7 expression marks mammary tumor–initiating cells
The WNT signaling pathway has long been implicated in tumorigenesis across multiple cancer types, including breast cancer. However, the complexity arising from the large number of WNTs and their recep...
Estimated impact of 2022–2023 influenza vaccines on annual hospital burden in the United States
During the COVID-19 pandemic early years, infection prevention measures suppressed transmission of seasonal influenza and other respiratory viruses. The early onset and moderate severity of the US 202...