Proceedings of the National Academy of Sciences
Articles in this Issue
Sirt6 prevents the age-related decline of H <sub>2</sub> S through the control of one-carbon metabolism
Mice overexpressing Sirt6 or fed a caloric restriction (CR) diet live longer with improved health. CR increases Sirt6 levels, and its beneficial effects are mediated by the gasotransmitter H...
Forward genetic screening in engineered colorectal cancer organoids identifies regulators of metastasis
Metastatic outgrowth requires that cancer cells delaminate from the primary tumor, intravasate, survive in circulation, extravasate, migrate to, and proliferate at a distal site. Recurrent genetic dri...
Physiologically based pharmacokinetic model for CAR-T cell delivery and efficacy in solid tumors
Abnormal blood vessels limit the delivery and function of endogenous T cells as well as adoptively transferred Chimeric Antigen Receptor (CAR)-T cells in tumor microenvironment (TME). We recently show...
Diffuse pacemaker mechanism with distinctive organization drives pulsation in the octocoral <i>Xenia umbellata</i>
The unique, hypnotic pulsation behavior of certain soft corals of the Xeniidae family, the result of rhythmic opening and closing of their tentacles, has fascinated scientists since the 18th century....
Regulation of epithelial tissue homeostasis by active transepithelial transport
Epithelia are intricate tissues whose function is intimately linked to mechanics. While mechanobiology has primarily focused on factors such as cell-generated contractility and mechanical properties o...
General laws of biodiversity: Climatic niches predict plant range size and ecological dominance globally
A longstanding question in ecology asks whether or not species that achieve large geographic ranges also have large climatic niche breadths. Using a dataset of ~250,000 terrestrial plant species spann...
Mechanomedicine: Present state and future promise
Two recent conferences on mechanotransduction in biology and medicine showcased remarkable progress in this field and the potential for bringing mechanobiology into the clinic. In this Perspective, we...
PAK2-driven cytoskeleton–endosome dynamics control macrophage hyperphagia and SIRPA engagement
Macrophages rely on dynamic cytoskeletal rearrangements to respond to their environment. This plasticity supports biomechanical transitions and functional polarization, mediating tissue homeostasis, a...
Electrokinetic nanoparticle transport in an interconnected porous environment: Decoupling cavity escape and directional bias
Electrokinetic transport of nanoparticles in porous media is crucial for separation technologies, but the boundary-field coupling effects in three-dimensional (3D) interconnected porous spaces remain...
Machine-learning models based on histological images from healthy donors identify imageQTLs and predict chronological age
Histological images offer a wealth of data. Mining these data holds significant potential for enhancing disease diagnosis and prognosis, though challenges remain, especially in noncancer contexts. In...
Erythroid precursors regulate local oxygen tension and repair outcomes in the bone marrow niche
Oxygen tension dynamically regulates stem cell fate and tissue regeneration, yet how local oxygen availability is controlled within the bone marrow niche remains poorly understood. While bone marrow i...
Testing whether connectivity stabilizes metacommunities and rescues declining diversity in a 25-y grassland study
Theory predicts that metacommunities, or connected ensembles of local communities, can be stabilized by dispersal in the face of environmental changes. Using a 25-y dataset from 80 grassland sites emb...
Neither inaccurate nor biased in later life: Age-related differences in the accuracy and bias of facial trustworthiness judgment
People tend to form impressions of others’ trustworthiness based on their facial appearance and make trust-related decisions accordingly. In such face-based trustworthiness judgments (FBTJs), older ad...
High-energy impact and vapor recondensation history of the angrite parent body revealed by nickel isotopes
The angrite parent body (APB) is the most volatile-depleted among known differentiated bodies in the Solar System, yet the mechanisms responsible remain poorly constrained. Here, we present high-preci...
Strategy for coordinating near-term PM <sub>2.5</sub> , ozone, and CO <sub>2</sub> mitigation in China
China faces the challenge of simultaneously improving fine particulate matter (PM 2.5 ) and ozone (O 3 ) air quality whi...
Early female germline development in <i>Xenopus laevis</i> : Stem cells, nurse cells, and germline cysts
In Drosophila, germline cysts arise through synchronous mitotic divisions and acquire a polarized architecture organized by the fusome, which guides oocyte specification and supports meiotic progressi...
Auxin transport positions stem cells in the vascular cambium during normal development and regeneration
The vascular cambium contains bifacial stem cells producing secondary phloem in one and secondary xylem to the opposite direction. In Arabidopsis roots, these s...
Spatial variation in the mutation rate within the plant shoot apical meristem
The potential impact of new mutations on organismal function and evolution depends on the developmental fate of the affected cells. Stem cells in the shoot apical meristem form much of the plant body,...
Genome synthesis, assembly, and rebooting of therapeutically useful high G+C% mycobacteriophages
Bacteriophages show therapeutic promise for treating bacterial pathogens including nontuberculous mycobacteria (NTM). A major impediment is the paucity of therapeutically useful phages and the great v...
The invisible subsoil compaction risk under no-till farming
No-till (NT) is a key component of conservation agriculture aiming at producing crops with minimal soil disturbance. This land management practice offers numerous economic and ecological advantages ov...
Forecasting weather and health heat impact
Fluorescein-based dyes are not valid reporters of oxidative stress in bacteria, and conclusions based on their use must be reconsidered
Dihydrodichlorofluorescein derivatives have been employed as reporters of intracellular reactive oxygen species (ROS) in innumerable studies. Their use in bacteria has led investigators to conclude th...
Warming waters herald a submarine eruption
Pressure-induced redox reversal of iron and the distribution of elements in deep Earth
We demonstrate a remarkable change in the chemical bonding of iron under pressure that underlies the distribution of elements in the Earth’s mantle and core. Using a massive-scale, first-principles st...
Design strategies for ion-sieving charge mosaic membranes toward sustainable lithium extraction
Membrane-based technologies are essential for realizing sustainable ion-sieving processes such as lithium extraction. Much effort was devoted to designing new membrane materials, whereas the effect of...