Proceedings of the National Academy of Sciences
Articles in this Issue
Hypermutable hotspot enables the rapid evolution of self/non-self recognition genes in <i>Dictyostelium</i>
Cells require highly polymorphic receptors to perform accurate self/non-self recognition. In the amoeba Dictyostelium discoideum ,...
Occludin acts as a dynein adaptor regulating permeability and collateral angiogenesis
Previous studies of the tight junction protein occludin (OCLN) suggest that multiple phosphorylation sites on the carboxy-terminal domain contribute a regulatory role in vascular barrier properties. H...
Designing strongly coupled polaritonic structures via statistical machine learning
Strong coupling photonics, in which coupling strengths significantly exceed decay factors, holds great promise for applications in energy conversion and information processing. However, the effective...
Climate change has already made the United States poorer
The climate is already changing. The present study shows that these changes have already affected the U.S. economy. It develops a formal framework that accounts for how climate change has affected eac...
Cilia-driven epithelial folding and unfolding in an early diverging animal
Multicellular organisms utilize epithelial folding to achieve remarkable three-dimensional forms. During embryonic development, stereotypical epithelial folds emerge from underlying active cellular an...
Quantifying the contributions of climate change and adaptation to mortality from unprecedented extreme heat events
Understanding the mortality effects of the most extreme heat events is central to climate change risk analysis and adaptation decision-making. Accurate representation of these impacts requires account...
Potential yield and food provisioning gains from rebuilding the world’s coral reef fish stocks
Many coral reefs have fish stocks that are depleted below the level at which sustainable production is maximized. Lower production means that millions of people are losing out on potential food, incom...
Physical exercise increases binding of POMC to blood extracellular vesicles
Physical exercise affects multiple physiological processes, including those regulated by hormones, such as energy balance, stress responses, and pain perception. The prohormone precursor proopiomelano...
Domestication is adaptive evolution in response to human use
Toward a general understanding of thermal performance curves in biology
Reply to Loh: Evaluating anger as a mediator of criticism’s effect on social media engagement using the interventional effects approach
Individual incentives that promote collective intelligence
A collaborative group can often outperform a single individual in complex problem solving, even when information is limited. This phenomenon, called collective intelligence, can be achieved by enginee...
Reply to Kohl: Moving beyond the 19th-century view of domestication
Promoters of cooperation in evolutionary games
Evolutionary games provide a flexible mathematical framework for many problems in biology and social evolution. Prisoners’ dilemma, and in particular, the important special case of donation games, rep...
Leaf beetles employ tryptophan to detoxify the chemical defenses of poplar trees
Herbivorous insects have evolved many fascinating adaptations to overcome the chemical defenses of their host plants. This study employed targeted and untargeted metabolomics, coupled with isotope lab...
Dynamic functional connectivity following cochlear implantation: Predicting speech outcomes and exploring brain network dynamics
Cochlear implants (CIs) have transformed hearing restoration for individuals with severe or profound hearing loss, yet outcomes vary widely and remain difficult to predict. This study introduces an ap...
Rising rates of wildfire building destruction in the conterminous United States
Many regions of the world have seen an increase in highly destructive wildfires, driven by well-documented increases in burned area and growth of housing in the wildland–urban interface (WUI), which e...
Medial entorhinal VIP-expressing interneurons receive input from the thalamic anterior dorsal nucleus and are critical for spatial memory
Vasoactive intestinal peptide (VIP) cells have emerged as a crucial component of the inhibitory network, facilitating interregional communication, particularly in the context of associative memory. To...