Proceedings of the National Academy of Sciences
Articles in this Issue
Derepression of transposable elements in the mouse prefrontal cortex disrupts social behavior
The neurobiological origins of social behaviors are poorly understood. Previous studies have linked the function of a single Krüppel-associated box zinc finger protein (KZFP), ZFP189, in the mouse pre...
Crucial roles of mesenchymal <i>Gata2</i> in murine epididymal development
Androgens drive the morphogenesis and differentiation of the Wolffian duct (WD) into the epididymis, an essential organ for male reproduction, by binding to the androgen receptor (AR). However, it rem...
Correction for Goteti et al., Collective neural network behavior in a dynamically driven disordered system of superconducting loops
Correction for Wang et al., Engineering bacteria for cancer immunotherapy by inhibiting IDO activity and reprogramming CD8+ T cell response
Correction to Supporting Information for Han et al., CASKIN2 mediates PTPσ-orchestrated transsynaptic mechanisms at excitatory synapses
The “machinal bypass” and how we’re using AI to avoid ourselves
David John “Davo” Mangelsdorf (1958–2025): A life of science, friendship, and joy
David John “Davo” Mangelsdorf passed away on August 3, 2025, in Dallas, Texas at age 67 from an unexpected postsurgical complication. Davo made transformative contributions to nuclear receptor and met...
Structural insights into human signal peptide peptidase
The signal peptide peptidase (SPP) remains the only intramembrane protease family that is yet to be structurally characterized. Here, we report the cryoelectron microscopy (cryo-EM) structures of huma...
Lab on an end: Micromanipulation using the acoustohydrodynamic pillar array as an end effector
The concept of microfluidics has shown considerable promise for advancing chemistry, diagnostics, and biology. However, there have been no guaranteed routes of microfluidics that can achieve widesprea...
Turncoat antibodies unmasked in a model of autoimmune demyelination: From biology to therapy
Autoantibodies contribute to many autoimmune diseases, yet there is no approved therapy to neutralize them selectively. A popular mouse model, experimental autoimmune encephalomyelitis (EAE), could se...
Correction for Agrawal and Dehaene, From retinotopic to ordinal coding: Dissecting the cortical stages of visual word recognition
Flat-band tuning and emergent itinerant magnetism in Sr(Co <sub> 1− <i>x</i> </sub> Pd <sub> <i>x</i> </sub> ) <sub>2</sub> As <sub>2</sub>
The interplay between magnetism and flat-band (FB) instability is a central theme in quantum materials research. A striking example is the emergence of magnetic order in a nominally nonmagnetic compou...
Learning to learn ecosystems from limited data
A fundamental challenge in developing data-driven approaches to ecological systems for tasks such as state estimation and prediction is the paucity of the observational or measurement data. For exampl...
A further modification of the elastic field of an edge dislocation
A previous modification removed a nonphysical divergence of the elastic displacement field of an edge dislocation. The traditional elastic equations are correct to linear elastic order. However, there...
Evolution of repressive sequences within an enhancer contributed to morphological diversity in crucifer plants
Cis -regulatory sequences, such as enhancers, play a crucial role in morphological evolution, but how their diversification leads to evolution of novel expression patterns that und...
An abundant membrane protein in the NCAM superfamily is required for epithelial organization in sea anemone embryos
Assembly of cells into epithelial layers marks the early steps of tissue organization and embryonic development in most animals. Although several conserved proteins are known to be essential for epith...
Cryo-EM structure of the Rift Valley fever virus envelope protein in complex with a potent neutralization antibody
Entry of Rift Valley fever virus (RVFV) into host cells is mediated by the viral glycoproteins Gn and Gc. Structural details and assembly mechanism of Gn and Gc on the surface of RVFV remain unclear....
Four-hour thunderstorm nowcasting using a deep diffusion model for satellite data
Convection (thunderstorm) develops rapidly within hours and is highly destructive, posing a significant challenge for nowcasting and resulting in substantial losses to infrastructure and society. Afte...
Asymmetrical recognition and processing of double-strand breaks formed during DNA replication
DNA end resection to generate 3′ single-stranded DNA (ssDNA) overhangs is the first step in homology-directed mechanisms of double-strand break (DSB) repair. While end resection has been extensively s...
MLKL/retromer axis controls PD-L1 recycling to compromise antitumor immunity during VCP inhibition–induced necroptosis
The activation of the vesicular trafficking system, including endosomal recycling and extracellular vesicle (EV) release, represents an adaptive mechanism in cancer cells to counteract cellular stress...
Beyond static pores: A dynamic mechanism of antimicrobial action
The kinesin-4 protein KIF27 forms a cytoskeletal scaffold at the transition zone to promote motile cilia structural integrity
Motile cilia are eukaryotic organelles with essential chemo- and mechanosensing functions across evolution, from single cell organisms to humans. Motile cilia of the mammalian nervous, respiratory, an...
DIS3L2-mediated RNA surveillance and extracellular vesicle packaging prevent innate immune activation by aberrant cellular RNAs
Although most studies of the RNAs within extracellular vesicles (EVs) have focused on messenger RNA (mRNA) and microRNAs (miRNAs), recent analyses have revealed that transfer RNAs (tRNAs) and other no...
Mysterium vitreum: Revealing the hidden polyhedral order of glass
Cognition varies across the calendar year in multiple large-scale datasets
Children’s cognitive abilities vary across short and long timescales, from circadian fluctuations to year-by-year developmental changes. “Summer slide” refers to seasonal variation in academic perform...