Blood
Articles in this Issue
Safety and efficacy of elranatamab + nirogacestat in patients with relapsed or refractory multiple myeloma: Results from the Phase 1b MagnetisMM-4 study
Abstract Background Elranatamab (ELRA) is a bispecific antibody (BsAb) targeting B-cell maturation antigen (BCMA) on myeloma cells and CD3 on...
Systematic molecular profiling to identify determinants of response to ibrutinib
Abstract BACKGROUND Whilst the broad clonal architecture of naturally progressing chronic lymphocytic leukemia (CLL) has been described, a co...
Trends and disparities in multiple myeloma mortality in the United States: A 25-year analysis from 1999 to 2023
Abstract Introduction Multiple myeloma (MM) is a hematological malignancy characterized by clonal proliferation of plasma cells within bone...
Practice pattern and outcomes in DLBCL by Genetic Subtypes: Preliminary results from a large-scale real-world study in China
Abstract Introduction: Diffuse large B cell lymphoma (DLBCL) is genetically heterogenous, comprising distinct molecular subtypes (MCD, BN2, N...
Functional drug response profiling predicts clinical outcomes and shows utility for treatment stratification in AML
Abstract Background Selecting the optimal therapy in acute myeloid leukemia (AML) can be clinically challenging—particularly for patients wi...
Efficacy and safety of the LSD1 inhibitor bomedemstat in participants with polycythemia vera (PV) resistant or intolerant to cytoreductive therapy: The Phase 2 shorespan-004 study
Abstract Introduction: PV is a JAK2-driven myeloproliferative neoplasm (MPN) characterized by an erythroid dominant trilineage proliferation...
Major bleeding and stroke in patients with hemophilia and atrial fibrillation
Abstract Background Congenital hemophilias affect about 30,000 US individuals (0.01% of the population) and atrial fibrillation (AF) about 1...
Global assessment of patient and caregiver unmet needs in myeloproliferative neoplasms (MPNs): Findings from the 2024 international assessment
Abstract Background Despite therapeutic advances, patients with myeloproliferative neoplasms (MPNs) continue to face sig...
Revisiting the therapeutic potential of fenretinide in acute erythroid and acute megakaryoblastic leukemias
Abstract N-(4-hydroxyphenyl)retinamide (4-HPR, also known as Fenretinide) is a synthetic derivative of vitamin A with well-established anti-...
Cost-effectiveness of CAR-T cell therapy compared to bispecific T-cell engagers in Relapsed/Refractory multiple myeloma: A retrospective study using a markov model
Abstract Introduction: Multiple myeloma (MM) is considered an incurable malignancy, but with modern therapies, patients can achieve deep and...
Correlation of antral follicle count and antimullerian hormone in women with sickle cell disease
Abstract Background: Ovarian reserve is compromised in adults with sickle cell disease (SCD), but whether SCD treatment exposures drive this...
Safety and preliminary efficacy of combined lenalidomide and CD19 CAR T-cell therapy in relapsed/refractory CLL: A phase I study
Abstract Introduction Despite the clinical efficacy of CD19 CAR-T cells in Non-Hodgkin lymphomas, the clinical efficacy of CD19 CAR T-cell t...
The chromatin remodeler hells regulates transcription-replication conflicts and genome integrity in ALK-negative anaplastic large cell lymphoma
Abstract Transcription and replication both utilize genomic DNA as a template, creating the potential for frequent interference between the...
Pharmacokinetics, pharmacodynamics, and biomarkers of lbl-034, a GPRC5D-targeted T cell engager, in a first-in-human phase Ⅰ/Ⅱ study in relapsed/refractory multiple myeloma
Abstract Introduction: LBL-034 is a humanized IgG1 subtype asymmetric bispecific antibody targeting GPRC5D and CD3 with a 2:1 format. Its aff...
Exploring co-mutations in CML and ph(+) b-ALL with ABL1 variants: Correlations with survival and treatment response.
Abstract Introduction: The impact of co-mutations seen with ABL1 kinase domain mutations is unclear in today's treatment landscape (Branford...
Replication fork remodeling is a therapeutic vulnerability in acute myeloid leukemia
Abstract Objectives: Acute myeloid leukemia (AML) is mostly driven by specific mutations that affect transcription factors and epigenetic re...
Cardiopulmonary complications of DIC in AML: A nationwide inpatient study
Abstract Background: Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults, accounting for approximately 80% of ad...
Optimising MRD-guided treatment: UMRD4 as a half-way treatment timepoint for ibrutinib-venetoclax substantially delays MRD relapse after end of treatment in both IGHV-mutated and IGHV-unmutated CLL.
Abstract Introduction: The FLAIR (ISRCTN01844152) phase III trial for previously untreated fit CLL patients showed that measurable residual...
3-year follow-up of the S1826 study confirms improved progression-free survival with nivolumab-AVD compared to brentuximab vedotin-AVD in advanced stage classic Hodgkin lymphoma
Abstract Introduction: The randomized phase 3 S1826 study demonstrated that, in adolescent and adult patients (pts) with previously untreate...
Longitudinal assessments of simple frailty tools can help predict outcomes of patients undergoing chimeric antigen receptor T-cell (CAR-T) therapy: A prospective pilot study at Princess Margaret Cancer Centre
Abstract Introduction Chimeric Antigen Receptor T-Cell (CAR-T) therapy has become the preferred treatment for patients w...
Influence of air quality on clinical acuity at presentation in pediatric patients with newly diagnosed Acute Myeloid Leukemia
Abstract Introduction: Clinical acuity at presentation is a predictor of mortality and a mediator of racial disparities in early mortality i...
Complement inhibition in post-transplant IgA-mediated autoimmune cytopenia: A pediatric case report
Abstract Background: Autoimmune hemolytic anemia (AIHA) is a well-described complication in pediatric populations and solid organ transplant...
Safety and efficacy of brexucabtagene autoleucel in elderly patients with relapsed or refractory Mantle Cell Lymphoma: A retrospective, multicenter, international study
Abstract Purpose: Mantle cell lymphoma (MCL) predominantly affects older adults, who may be ineligible for intensive therapies. Limited data...
A phase II multi-institutional Study evaluating the safety and efficacy of the combination of lisocabtagene maraleucel and zanubrutinib in patients with richter transformation
Abstract Richter transformation (RT) occurs in ~4% of patients with chronic lymphocytic leukemia/ small lymphocytic lymphoma (CLL) and is as...
Long term follow-up and results of retreatement after obinutuzumab-venetoclax in first-line CLL patients with coexisting conditions
Abstract Introduction In the HOVON 139/GiVe trial previously untreated CLL patients unfit for FCR received 2 cycles of obinutuzumab monothera...