Blood
Articles in this Issue
Pre- or post-CAR-T allogeneic hematopoietic cell transplant provides relapse-free survival benefit for R/R Philadelphia negative B-cell acute lymphoblastic leukemia (B-ALL) successfully treated with brexucabtagene autoleucel in the real world
Abstract Introduction: Brexucabtagene autoleucel (Brexu-cel) is a CD19-targeted chimeric antigen receptor (CAR-)T cell therapy approved for...
Efficacy of brentuximab vedotin combination treatment in patients with relapsed or refractory diffuse large B-cell lymphoma with CD30 <1% expression
Abstract Introduction Diffuse large B-cell lymphoma (DLBCL) is a heterogenous disease with varied expressions of CD30. Brentuximab vedotin (...
Uncovering the genomic landscape of DLBCL in Latin America: First report of two centers from Brazil and Chile
Abstract Background: DLBCL is a biologically heterogeneous disease whose genomic landscape has been extensively mapped in high-income countr...
Comparison of traditional vs novel approach to define cancer-associated bleeding
Abstract Introduction Bleeding is a frequent yet under-captured complication in cancer patients undergoing systemic therapy. While Internati...
Integrating single-cell whole genome and transcriptome sequencing to track the clonal evolution of TP53-mutated myeloid neoplasms
Abstract Introduction: TP53 mutated myeloid neoplasms (MNs) are associated with aberrant copy number variations (CNVs), complex karyotype (C...
IDH1/2 mutations predict a distinct high-risk subset in Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia
Abstract Background: IDH1/2 mutations are very rare in B-cell acute lymphoblastic leukemia (B-ALL), and there are few data on their prognosti...
A post hoc safety analysis of fixed-duration acalabrutinib-venetoclax combinations vs chemoimmunotherapy: Results from the phase 3 AMPLIFY trial
Abstract The AMPLIFY trial assessed fixed-duration (FD) acalabrutinib + venetoclax (AV) or AV + obinutuzumab (AVO) vs fludarabine + cyclopho...
Andean high-altitude dwellers with the NFKB1 haplotype (rs230511) are protected from acute mountain sickness
Abstract Acute Mountain Sickness (AMS) occurs with rapid ascent to high altitudes (>2,500m), where air and oxygen pressures are lower...
Comparative safety and efficacy of first- and second-generation FLT3 inhibitors in newly diagnosed and relapsed AML: A meta-analysis stratified by molecular biomarkers
Abstract Background: FMS-like tyrosine kinase 3 (FLT3) mutation, including tyrosine kinase domain mutation and internal...
Prognostic impact of co-occurring mutations in NPM1-mutated Acute Myeloid Leukemia
Abstract Background: NPM1 is the most commonly mutated gene in adult acute myeloid leukemia (AML). Per ELN 2022, NPM1-mutated AML is classif...
Anti-inflammatory drug pegtarazimod (RLS-0071) demonstrates clinical improvement in lower gastrointestinal acute graft-versus-host disease (aGvHD) and target engagement of key inflammatory marker myeloperoxidase (MPO)
Abstract Introduction: Acute graft versus host disease (aGvHD) remains a common complication for patients receiving allogeneic hematopoietic...
Impact of optimizing the serum ferritin threshold for diagnosis of iron deficiency: A pre- and post-intervention study using EHR data
Abstract Background Iron deficiency (ID), with or without anemia (IDA or IDWA) is one of the most prevalent and underdiagnosed conditions gl...
Malignancy-associated internal jugular venous thrombosis following chemoradiation for oropharyngeal carcinoma
Abstract Background: Head and neck squamous cell carcinoma (HNSCC), particularly HPV-associated oropharyngeal cancer, frequently requires mu...
A new HDAC1/2 degrader increases HbF production in human CD34⁺ cells at non-cytotoxic, differentiation-preserving dose
Abstract Introduction: The reactivation of HBG1/2 gene expression is a validated therapeutic strategy for treating β-hemoglobinopathies, suc...
Effectiveness and prognostic impact of BMI, MRD and CNS involvement in AYA patients with Philadelphia-negative ALL treated using the AYA-15 protocol: Real-world from a tertiary center in the middle east
Abstract Background Pediatric-inspired chemotherapy regimens have improved outcomes in adolescents and young adults (AYA) with acute lymphob...
The dilemma of glycemic control: Hemoglobin A1c or fructosamine as a measurement related to serum iron
Abstract Hemoglobin A1c (HbA1c) is widely recognized as the gold standard biomarker for assessing long-term glycemic control in individuals...
Combination of mitoxantrone hydrochloride liposome with CLAG regimen in patients with relapsed or refractory Acute Myeloid Leukemia: A prospective, single-arm study
Abstract Background:Relapsed or Refractory acute myeloid leukemia (R/R AML) carries a poor prognosis with currently no standard salvage ther...
Bone marrow adipocytes (BMA) as a novel biomarker of molecular response in patients with essential thrombocythemia (ET) and polycythemia vera (PV) treated with pegylated interferon alfa-2A
Abstract Background: The functional importance of bone marrow adipocytes (BMA) is frequently overlooked even though they are critical compon...
Experience of management of patients with acute promyelocytic leukemia (APL) in Armenia.
Abstract Introduction. Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia caused by specific translocation b...
Survival impact of anti-CD38-based quadruplet regimens in transplant-ineligible newly diagnosed multiple myeloma: A network meta-analysis and reconstructed individual patient data meta-analysis
Abstract Introduction: Frontline therapy for transplant-ineligible newly diagnosed multiple myeloma (TI-NDMM) has evolved significantly. Alt...
Metabolic reprogramming via targeting the medium-chain fatty acid receptor enhances the anti-tumor activity of lymphocytes in cancer immunotherapy
Abstract The tumor microenvironment (TME) poses a significant challenge to the success of T cell-based immunotherapies. Upon arrival, follow...
IDH mutant MDS: Proposal for disease subset recognition based on molecular and clinical features, and the availability of targeted therapies
Abstract Introduction IDH1 & IDH2 somatic mutations (MT) are described in in 5-10 % of myelodysplastic syndromes (MDS) cases. Recognition...
Weekend admission and in‑hospital outcomes in cancer-related pulmonary embolism (CAP): A 2016–2022 national inpatient sample study
Abstract Introduction Cancer-related pulmonary embolism (CAP) is a common, lethal complication in patients with solid or hematologic maligna...
Outcomes of patients with mayo stage IIIb systemic AL amyloidosis treated with daratumumab-based frontline therapy
Abstract Introduction Patients with Mayo stage IIIb AL amyloidosis (defined as NT-proBNP>8500 pg/mL and high-sens...
Efficacy and safety of romiplostim N01 combined with cyclosporine in refractory aplastic anemia patients：a multicenter phase II study
Abstract Background: Patients with aplastic anemia (AA) who are refractory to immunosuppressive therapy (IST) combined with thrombopoietin re...