Blood
Articles in this Issue
Effect of white blood count and absolute monocyte count on kidney function in chronic myelomonocytes leukemia (CMML)
Abstract Introduction Kidney injury is a common finding in patients with myeloproliferative neoplasms (MPN) such as CMML. Its etiology is mu...
CPX-351 versus venetoclax plus hypomethylating agents for newly diagnosed acute myeloid leukemia: A systematic review and meta-analysis
Abstract Introduction: Acute myeloid leukemia (AML) is one of the most common types of acute leukemia. Since the median age at diagnosis is...
Selective degradation of oncogenic signaling nodes by momelotinib-based protacs exerts potent anti-leukemic response in B-ALL, AML, and MF while sparing normal cells
Abstract Despite notable advancements in developing targeted tyrosine kinase inhibitors (TKIs) therapy for hematologic malignancies such as...
Describing the feasibility and acceptability of an electronic adherence monitor to measure hydroxyurea adherence among youth with sickle cell disease
Abstract Background: Prescription and claims data suggest hydroxyurea (HU) adherence is low among >50% of youth w...
Perioperative use of efanesoctocog alfa in Hemophilia A: A dual-center real-world study
Abstract Background: Persons with Hemophilia A (PWH) are at high risk of bleeding during and after surgery. Standard per...
MSK-impact heme accurately reproduces diffuse large B-cell (DLBCL) dlbclass cluster classification across clinical scenarios, including diagnosis, relapse, and histological transformation
Abstract Background: Molecular classifications of diffuse large B-cell lymphoma (DLBCL) can identify patient groups that benefit from distin...
Integrative analysis of the interplay between peripheral immune landscape and leukemic blast adaptation in Acute Myeloid Leukemia
Abstract Introduction and aims: With the rapid development of immunotherapeutic strategies in acute myeloid leukemia (AML), it has become in...
A comparison of overall survival and quality of life in MDS patients treated with azacytidine vs decitabine: A propensity matched registry Study
Abstract Background Myelodysplastic neoplasms (MDS) are a group of clonal malignancies of hematopoietic stem cells where progressive cytopeni...
Trends in chronic lymphocytic leukemia mortality among older adults with renal failure in the United States: A 25-year retrospective study.
Abstract Background: Renal failure is a frequent comorbidity in patients with chronic lymphocytic leukemia (CLL), contributing to poor outco...
DATA structuring and performance indicators for decision making in oncology and hematology
Abstract Background: Digital transformation in Brazilian hospitals has heightened the demand for high-quality data and strategic indicators...
Novel insights in therapeutic antibody therapies using advanced microscopy techniques
Abstract Introduction Immunotherapies have shown exceptional potential in achieving deep and durable remissions in Multiple Myeloma (MM). Ho...
Tuscany Study demonstrates safety and efficacy of tuspetinib plus standard of care venetoclax and azacitidine in patients with newly diagnosed AML ineligible for induction chemotherapy
Abstract BACKGROUND The combination of venetoclax (VEN) with azacitidine (AZA) improves response rates and overall survival in newly diagnos...
Clinical use of genome-wide hi-c sequencing for assessment of structural variants in diffuse large B-cell lymphoma
Abstract Introduction: Diffuse large B-cell lymphoma (DLBCL) is a common and aggressive B-cell malignancy with heterogeneous genomic finding...
Asciminib as initial therapy with addition of lower dose tyrosine kinase inhibitors (TKIs) for patients with chronic myeloid leukemia who do not achieve optimal response or a deep molecular remission
Abstract Background: Asciminib, an allosteric inhibitor of BCR::ABL1, has the potential to promote deeper molecular response (DMR) with redu...
Effects of antibiotic prophylaxis in first-line therapy of advanced stage classic Hodgkin lymphoma: An analysis of the GHSG HD21 study
Abstract Introduction: The benefit of antibiotic prophylaxis (ABP) during chemotherapy for cancer remains controversial. The growing resistan...
Real-world sequencing of anti-BCMA CAR T-cells and bispecific T-cell engagers in Relapsed/Refractory multiple myeloma: A multi-country analysis
Abstract Background Multiple myeloma (MM) is the second most common hematologic malignancy, driven by uncontrolled plasm...
Phase 3 study (inMIND) of tafasitamab plus lenalidomide and rituximab for relapsed or refractory follicular lymphoma: Clinical characteristics and outcomes by age
Abstract Introduction: Incidence of follicular lymphoma (FL) increases with age and patients (pts) often relapse, requiring multiple lines of...
TSC-101 eliminates recipient hematopoietic cells and demonstrates potential for improved relapse-free survival in patients with AML, ALL, or MDS undergoing allogeneic HCT: Updated results from the Phase 1 (ALLOHA) trial
Abstract Disease relapse is the leading cause of death after reduced-intensity conditioning (RIC)-based allogeneic hematopoietic cell transp...
Impact of pulmonary hypertension on in-hospital outcomes among patients hospitalized with multiple myeloma: A 2015–2022 national inpatient sample analysis
Abstract Background: Pulmonary hypertension (PH) is a serious disease that complicates a range of hematologic and cardiovascular disorders....
Real-world analysis of thromboprophylaxis use during autologous hematopoietic stem cell transplantation for lymphoma and multiple myeloma
Abstract Background Patients with hematologic malignancy who undergo treatment become thrombocytopenic, and thromboprophylaxis (VTE ppx) is o...
Efficacy of frontline fixed duration chemotherapy in MAPK-pathway altered adult langerhans cell histiocytosis: A multi-institutional international retrospective study
Abstract Introduction: Langerhans Cell Histiocytosis (LCH) is a rare histiocytic neoplasm, with approximately 90% of patients exhibiting alt...
ABC: Highly active and entirely calcineurin and m-TOR inhibitor-free gvhd prevention regimen
Abstract Background: We previously reported results of posttransplant cyclophosphamide (PTCy) and bortezomib (CyBor) combination in graft-ve...
Outcomes with chimeric antigen receptor-t cell therapy in relapsed/refractory b-cell acute lymphoblastic leukemia: A systematic review and meta-analysis
Abstract Introduction: B-cell acute lymphoblastic leukemia (B-ALL) has a very high relapse rate, with dismal median overall survival (mOS) a...
A genome-wide CRISPR activation screen identifies novel γ-globin regulators
Abstract β-hemoglobinopathies, the most common monogenetic blood disorders, result from defective function or inadequate production of β-glo...
Cognitive and physical disability after traumatic brain injury in patients with sickle cell disease: A national cohort study from the all of us research program
Abstract Background: Traumatic brain injury (TBI) in patients with sickle cell disease (SCD) has never been studied despite potential biolog...