Blood
Articles in this Issue
An updated UK real-world analysis of factors affecting outcome following brexucabtagene autoleucel for relapsed or refractory adult acute lymphoblastic leukemia
Abstract Background The UK Adult ALL CAR-T panel - established May 2023 - promotes equity of access and consistent eligibility assessment fo...
Optimal dosing of vobramitamab duocarmazine, a CD276 (B7-H3) antibody-drug conjugate, leads to durable eradication of Acute Myeloid Leukemia in preclinical xenograft models
Abstract CD276 (B7-H3) is an immune checkpoint inhibitor aberrantly expressed in a majority of solid tumors and hematologic malignancies, wi...
α-synuclein aggregates inhibit reticulocyte maturation
Abstract Anemia is highly associated with Parkinson's disease (PD), yet the underlying mechanisms linking PD to erythropoiesis remain poorly...
Comparing the efficacy and safety of the ABC-14 regimen (Azacitidine, Venetoclax, and Chidamide) with traditional “3+7” intensive induction regimen or AB-14 regimen (Venetoclax Combined with Azacitidine) in newly diagnosed AML: Study protocol for a prospective, multicenter, randomized, open-label clinical trial
Abstract Background Induction therapy is the first critical step in the overall treatment of Acute myeloid leukemia (AML). The “3+7” regimen...
A chemotherapy-free regimen of sintilimab, rituximab, and lenalidomide ± polatuzumab vedotin in elderly patients with newly diagnosed diffuse large B-cell lymphoma
Abstract Our previous pilot study demonstrated that the combination of sintilimab, rituximab, and lenalidomide (sR2) is effective and well t...
Cdc42 controls spatial organization of autophagy in hematopoietic stem cells
Abstract Autophagy is a fundamental cellular process essential for hematopoietic stem cell (HSC) maintenance by removing damaged organelles/...
The infection spectrum in newly diagnosed Acute Myeloid Leukemia patients treated with venetoclax-based or conventional chemotherapy: A real-world retrospective study
Abstract To better characterize the infection risk profile associated with venetoclax-based regimens in AML, we conducted a retrospective an...
Immune reconstitution and infectious complications following CAR-T cell therapy
Abstract Background: CAR-T therapies have dramatically improved outcomes of relapsed/refractory B cell lymphoma patients (pts). However, thi...
HBB-mafk axis drives lipid metabolism reprogramming and tumor progression in diffuse large B-cell lymphoma
Abstract Background: Diffuse large B cell lymphoma (DLBCL), a heterogeneous disease, constitutes the most common subtype of non-Hodgkin lymp...
Biphasic effects of cyclophosphamide on l-asparaginase hypersensitivity and resistance in mice
Abstract Background: L-Asparaginase (ASNase), a crucial drug for childhood acute lymphoblastic leukemia (ALL) treatment, frequently causes a...
A platelet-activating, HPA-1a-specific maternal alloantibody identifies a pathogenic subpopulation with the potential to exacerbate fetal/neonatal alloimmune thrombocytopenia
Abstract Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a potentially life-threatening condition caused by maternal alloantibodies di...
Early identification of patients likely to benefit from paroxysmal nocturnal hemoglobinuria workup using machine learning on large-scale real-world data.
Abstract Background Paroxysmal Nocturnal Haemoglobinuria (PNH) is a rare (3.81 per 100K), treatable clonal hematopoietic...
Comprehensive mutational profiling and clinical outcome of adults AML with NUP98 rearrangement
Abstract Acute myeloid leukemia (AML) harboring NUP98 rearrangements (NUP98r) is recognized as a distinct entity in the 2022 WHO classificat...
A mammalian protein-based coacervate platform enables scalable engineering for CAR-T therapy
Abstract The advancement of CAR-T cell therapies has reshaped treatment strategies for hematologic malignancies, yet the production of genet...
Total effect of gestational hypertension on neonatal iron deficiency in very-preterm infants.
Abstract Background: Gestational hypertension (GH) is a major risk factor for adverse maternal and perinatal morbidity and outcomes, includi...
Monitoring MRD and clinical utility of DNMT3A R882 in AML by multiplex droplet digital PCR
Abstract ObjectiveCurrent clinical detection of the DNMT3A R882 variant is usually by NGS and sanger sequencing, but the traditional methods...
Noninvasive detection and monitoring of multiple myeloma by urinary surface-enhanced raman spectroscopy and machine learning
Abstract Abstract Background: Multiple myeloma (MM) is the second most common hematologic malignancy, characterized by high relapse rates an...
Dysfunction of the neurovascular unit (NVU) presents a novel indicator for CNS injury after allogeneic hematopoietic stem cell transplantation
Abstract Introduction: Graft-versus-host-disease (GVHD) is a common complication after allogeneic hematopoietic stem cell transplantation (HS...
EO2463 (EO) peptide immunotherapy combined with rituximab (R) for first-line treatment of low-tumor burden follicular lymphoma (FL): A feasibility evaluation in Study EONHL1-20/sidney (NCT04669171)
Abstract Background Single-agent R is a common 1st-line therapy for patients (pts) with FL, especially those with low-tumor burden advanced s...
Transient hepatic reconstitution of thymic factors using mRNA rejuvenates T cell immunity, and improves vaccination and cancer immunotherapy responses in aged hosts
Abstract Introduction: Aging impairs immune function and leads to increased vulnerability to infection, malignancy, and vaccine failure.Immu...
Alternating cycles of quiescent and proliferative cell states determine stemness and leukemia-initiation capacity in acute lymphoblastic leukemia
Abstract Background and significance. Stemness in acute myeloid leukemia (AML) is determined by a clonal hierarchy with rare, phenotypically...
Treatment strategies and outcomes in pediatric patients with immune thrombocytopenia (ITP) undergoing surgical procedures: A multicenter study
Abstract Introduction: Children with immune thrombocytopenia (ITP) may have an increased risk of perioperative bleeding. However, current IT...
Prolonged elranatamab treatment interruption in patients with relapsed or refractory multiple myeloma (RRMM) is feasible: A retrospective analysis from MagnetisMM-3
Abstract Background Elranatamab (ELRA) is a B-cell maturation antigen (BCMA)-CD3 bispecific antibody indicated for the treatment of adult pa...
Synergistic effects of ASXL1 and BCOR on hematopoiesis and MDS/AML progression
Abstract Background: Myelodysplastic syndromes (MDS) and MDS-transformed acute myeloid leukemia (AML) are hematologic malignancies that pose...
Comparative outcomes of CAR-T therapy in elderly (≥70 Years) versus younger (<70 Years) patients with relapsed/refractory multiple myeloma: A real-world propensity-matched cohort study
Abstract Background: Chimeric antigen receptor T-cell (CAR-T) therapies represent a major advance in the management of relapsed/refractory m...