Blood
Articles in this Issue
Outcomes of second hematopoietic stem cell transplantation for relapsed myelodysplastic syndrome: An updated analysis of Japanese nationwide transplant registry
Abstract Background Myelodysplastic syndrome (MDS) is associated with dismal outcomes after relapse following hematopoietic stem cell transp...
Beyond overall declines: Unequal trends in multiple myeloma mortality across racial and demographic subgroups in the United States from 2018-2023
Abstract Background: Multiple myeloma (MM) mortality has declined in the United States, yet racial and demographic disparities persist. Cont...
A first-in-human study of stx-0712, a CCR2+ cytotoxicity targeting chimera (CyTAC™) in patients with chronic myelomonocytic leukemia (CMML) and Acute Myeloid Leukemia (AML)
Abstract Background and Significance: CMML is a myeloid neoplasm characterized by hematopoietic stem and progenitor cell (HSPCs) monocytic bi...
Quality of life and organization of care in patients with chronic myeloid leukemia (CML) within the lombardy hematologic network (REL): The CML-OPERAP study
Abstract Background Chronic Myeloid Leukemia (CML) accounts for 10-15% of adult leukemias by incidence, with a rising prevalence of ~3/10000...
Complete donor chimerism following deceased-donor liver transplant in an adolescent with hepatitis-associated severe aplastic anemia
Abstract Aplastic anemia (AA) develops in up to 28% percent of children with indeterminate acute liver failure (ALF), often within two month...
Characterizing the biological function FOXO3 and its role as a predictive biomarker in HTLV-1 related adult T-cell leukemia-lymphoma
Abstract Adult T-cell leukemia-lymphoma (ATL) is a highly aggressive T cell malignancy with dismal prognosis caused by the human T-cell leuk...
GB3226, a novel, orally active, first-in-class small molecule inhibitor of ENL-yeats and FLT3 kinase for the treatment of Relapsed/Refractory Acute Myeloid Leukemia
Abstract Background: The YEATS domain of ENL is an epigenetic reader protein that binds to acetylation sites on histones and exerts transcri...
Disease characteristics and outcomes of acute lymphoblastic leukemia (ALL) in adults with central nervous system (CNS) involvement
Abstract Background: Despite major advances in the treatment of ALL and incorporation of CNS prophylaxis, the risk factors for and outcomes...
Extrafollicular B cell expansion in COVID-19 patients with prothrombotic antibodies linked to inflammatory and Th1 signatures
Abstract Despite the availability of effective vaccines, COVID-19 continues to pose a global health challenge. Severe acute COVID-19 cases a...
Prediction and prevalence of non-anemic iron deficiency (NAID) in early pregnancy
Abstract Background: Non-anemic iron deficiency (NAID) is estimated to affect up to 42% of early pregnancies and is associated with adverse...
Cardiovascular disease risk assessment in Japanese adults with hemophilia: Interim results of a multicenter study
Abstract Background Although patients with hemophilia have historically been considered at low risk for cardiovascular disease (CVD), recent...
Proteomic profiling of amyloid deposits in advanced systemic light-chain (AL) amyloidosis: Insights into clonal light chains, chaperone proteins, and cardiac involvement
Abstract Background: Systemic light-chain (AL) amyloidosis with advanced cardiac involvement is associated with markedly reduced survival. T...
Safety and efficacy of surovatamig (AZD0486) in adolescent and adult patients with relapsed or refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL): Updated Results from the Phase 1/2 SYRUS study
Abstract Introduction: Management of R/R ALL remains challenging. While CD19-targeted therapies haveshown compelling clinical activity, exist...
Improved outcomes in 17,908 acute myeloid leukemia patients across last three decades: Results from the multinational pethema registry
Abstract Background: The therapeutic landscape of acute myeloid leukemia (AML) has evolved substantially over the past three decades. While...
Risk of second primary malignancies and leukemic transformation in patients with Philadelphia chromosome-negative myeloproliferative neoplasms: A population-level US retrospective cohort study
Abstract INTRODUCTION There is sparse population-level data on the risk of second primary malignancy (SPM) and leukemic transformation in Phi...
Phenotypic characterization of chimeric ilt receptor natural killer (CIR-NK) cells targeting HLA-G+ tumors for allogeneic donor identification
Abstract Introduction HLA-G is an immunosuppressing MHC-IB that acts through ILT2 and ILT4 receptors to block allogeneic...
Dysregulation of NF-kb and p73 signal axes in chronic lymphocytic leukemia with gain-of-function mutated p53
Abstract Background: Genetic alterations in TP53 are common in CLL (10% at diagnosis, 40% at relapse) and are thought to be the foremost mar...
Identifying epigenetic vulnerabilities for treatment of HMA refractory myeloid leukemia
Abstract Introduction Epigenetic mutations (e.g. TETE2, ASXL1, DNMT3A) are a frequently occurring class of mutations in Acute Myeloid Leukemi...
Risk of second primary hematological malignancy post chimeric antigen receptor T-cell therapy in diffuse large B-cell lymphoma: Propensity-matched analysis using trinetx database
Abstract Background: Chimeric antigen receptor T-cell (CAR-T) therapy has improved the outcomes for patients with relapsed or refractory dif...
Continuous‑infusion cytarabine for leukoreduction in hyperleukocytic AML: A single‑center retrospective study
Abstract Background: Hyperleukocytosis (WBC > 50 × 10⁹/L) in acute myeloid leukemia (AML) is a medical emergency associated with a ≥2...
Pericapsular nerve block and ablation as a novel pain modifying strategy in sickle cell patients wiht refractory hip pain due to avascular necrosis
Abstract Introduction: People living with sickle cell disease (SCD) have an average of four to six pain crisis episodes requiring hospitaliz...
Registration and characterization of patients with Glucose-6-Phosphate Dehydrogenase Deficiency in Spain: A real-world study of the Spanish Erythropathology Group (GEE)
Abstract Introduction: Enzymatic deficiencies of red blood cells, or erythroenzymopathies, are rare genetic disorders that affect intraeryth...
A single center review of secondary hemophagocytic lymphohistiocytosis treatment and outcomes.
Abstract Authors: Brenda S. Castillo, MD, Stephen Njau, MD, Sarah Monsell, Aaron Boothby, MD, Paul C. Hendrie, MD, PhD, Prakash Vishnu, MD,...
Chronic lymphocytic leukemia mortality among u.S adults aged ≥65: A 56-year trend analysis and demographic disparities
Abstract Introduction: Chronic lymphocytic leukemia (CLL) is the most prevalent form of leukemia among older adults, with mortality trends i...
Clinical significance of RAS-MAPK pathway mutations in Acute Myeloid Leukemia: Insights from a retrospective cohort
Abstract Background Dysregulation of the RAS-MAPK signaling pathway is among the most common molecular abnormalities observed in neoplastic...