Blood
Articles in this Issue
Selenocysteine dependency renders central nervous system leukaemia therapeutically sensitive to ferroptosis
Abstract Background and significance: Central nervous system (CNS) directed therapy in acute lymphoblastic leukemia (ALL) remains a formidab...
BPI-2358 reprograms immunosuppressive macrophages and impairs leukemic progression in MN1-overexpressing AML In Vivo
Abstract Acute myeloid leukemia (AML) is an aggressive hematologic malignancy characterized by the accumulation of immature myeloid cells in...
Phase 1, open-label, multi-center trial of RPT1G in patients with Relapsed/Refractory Acute Myeloid Leukemia and high-risk Myelodysplastic Syndromes/neoplasms
Abstract Background: Nicotinamide phosphoribosyltransferase (NAMPT) controls how cells use energy and is central to human biology. NAMPT is...
Clinical characteristics, demographics, and survival outcomes in newly diagnosed CUX1-mutated Acute Myeloid Leukemia
Abstract Background: The CUX1 gene, known as CUT-like homeobox 1, is located on chromosome 7q22.1 and encodes several protein isoforms, part...
Adherence to the 2018 world cancer research fund/American institute for cancer research cancer prevention recommendations and mortality among blood cancer survivors
Abstract Background: Survivors of hematologic malignancies face elevated mortality risk, yet the impact of modifiable lifestyle factors on t...
Single-center retrospective analysis of maribavir in the treatment of refractory and drug-intolerant cytomegalovirus viremia and cytomegalovirus disease after allogeneic hematopoietic stem cell transplantation
Abstract Background Cytomegalovirus (CMV) infection is a common complication following allogeneic hematopoietic stem cell transplantation (a...
Combined KIT D816V and HαT blood testing: Development and validation of a targeted non-invasive work-up to guide invasive testing for systemic mastocytosis
Abstract Background: Systemic Mastocytosis (SM) is a rare myeloid neoplasm (prevalence of 0.01%) characterized by a clonal mast cell expansi...
Low incidence of agvhd with ptcy, tacrolimus and post-engraftment low dose ATG-based GvHD prophylaxis in haplo-identical donor transplantation and establish of new predict score for grade II-iv agvhd
Abstract Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative therapy for hematological malignancies while acute graft-ve...
Immune aging and macrophage inhibitory factor (MIF) – mediated stromal rewiring drives pre-malignant evolution in smoldering multiple myeloma
Abstract Background: Smoldering Multiple Myeloma (SMM) is an asymptomatic plasma cell disorder with high risk of progression, characterized b...
Baseline characterization of nutrition counseling and modifiable cardiovascular risk factors among childhood cancer survivors through EHR-linked data analytics
Abstract Background: Approximately 50% of childhood cancer survivors (CCS) will develop therapy-related cardiovascular (...
Single-dose IV ferric derisomaltose improves hematologic and patient-reported outcomes in pregnant individuals with iron deficiency anemia
Abstract Background: Iron deficiency anemia (IDA) affects over 40% of pregnancies worldwide and is associated with fatigue, reduced quality...
Development of a novel multiomic sequencing approach to characterize infused donor memory-like NK cells in an immune compatible environment
Abstract Background Cytokine-induced memory-like natural killer (mem-NK) cells have an enhanced capacity for proliferation and persistence c...
Chronic myeloid leukemia (CML) evolution is not encoded in single-cell microstates, but emerges from population-level macrostates
Abstract CML progression is defined by increased disease burden and potential for transformation to blastic phase (BP), yet the mechanisms a...
Incidence of severe infections in patients with multiple myeloma treated with immunoglobulin-replacement therapy
Abstract Introduction: Secondary immunodeficiency (SID) is an increasing concern in patients with multiple myeloma (MM). SID may be caused b...
Molecular subclusters across the continuum of myelodysplastic neoplasms and acute myeloid leukaemia define distinct clinical entities
Abstract Introduction The distinction between myelodysplastic neoplasms (MDS) and acute myeloid leukaemia (AML) is becom...
What can PTEN expression tell us about CML progression?
Abstract The introduction of tyrosine kinase inhibitors (TKIs) has revolutionized the natural course of Chronic Myeloid Leukemia (CML), sign...
Real-world treatment patterns of elranatamab in patients with multiple myeloma in Japan: Findings from the EVEREST study
Abstract Background Elranatamab is a B-cell maturation antigen (BCMA)-CD3–directed bispecific antibody approved in Japan for the treatment o...
High-throughput screening uncloaks actionable compounds for ttmv::rara AML
Abstract Abstract Acute myeloid leukemia (AML) with TTMV::RARA fusion, which exhibits clinical features resembling acute promyelocytic leuke...
Pregnancy and delivery outcomes in women with Hemophilia A and B: A multicenter cohort study from the Italian association of haemophilia centers
Abstract Introduction: Hemophilia A and B are traditionally recognized as X-linked recessive disorders that primarily affect males. However,...
BCMA-targeted CAR T-cell therapy in refractory autoimmune diseases: Initial Results from a Phase 1 clinical trial
Abstract Introduction: Chimeric antigen receptor (CAR) T-cell therapy offers a promising, targeted approach for treating severe, refractory...
EBV status of lymphoma specimens from Ethiopia: Initial categorization of pathology and epigenetic state of EBV
Abstract Background: Epstein-Barr virus (EBV) is an oncogenic herpesvirus that infects nearly all individuals by adulthood, with over 90% of...
Selinexor enhances the effect of venetoclax on Acute Myeloid Leukemia stem and progenitor cells by disrupting lysosomal function
Abstract Background: AML is a hematologic malignancy that originates from leukemia stem cells (LSCs) which maintain their self-renewal abilit...
Real-world experience with IDH inhibitors in Acute Myeloid Leukemia: A german multicenter analysis with a focus on differentiation syndrome
Abstract Introduction Mutations in IDH1 or IDH2 occur in 15-20% of acute myeloid leukemia (AML) cases and promote leukem...
Erythrocyte membrane-camouflaged JAK1 inhibitor for the treatment of hemophagocytic lymphohistiocytosis
Abstract Background: Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome driven by aberrantly activ...
Favorable outcomes including post-transplant survival are seen independent of baseline skin burden in treatment-naïve patients (pts) with blastic plasmacytoid dendritic cell neoplasm (BPDCN) treated with tagraxofusp (TAG): Subgroup analysis of a pivotal Trial
Abstract Introduction BPDCN is an aggressive orphan malignancy characterized by CD123 expression and involvement of the skin, bone marrow (B...