Blood
Articles in this Issue
Identifying individuals with DDX41 germline predisposition syndrome
Abstract Background: Deleterious DDX41 germ line variants cause a predisposition syndrome (DDX41-GPS) that increases the risk of myeloid neo...
Efficacy of CAR-T cell therapy in chronic lymphocytic leukemia: A meta-analysis
Abstract INTRODUCTION: Chronic Lymphocytic Leukemia (CLL) is the most common type of leukemia in the adult population in...
Targeting B- and T-cell lymphomas with anti-CXCR5 CAR T cell therapy
Abstract Chimeric antigen receptor (CAR) T cell therapy has shown unprecedented efficacy in B-cell leukemias and lymphomas. However, &gt...
Oxidative stress and hemoglobin-c denaturation drive hemoglobin SC pathophysiology and can be ameliorated by antioxidants and hydroxyurea
Abstract Background: Compound heterozygous Hemoglobin SC (HbSC) disease, historically considered a mild form of sickle cell disease, is now...
Clinically relevant bleeding and heavy menstrual bleeding among patients <21 years old with provoked VTE: Findings from the multinational kids-DOTT trial
Abstract Introduction Clinically relevant bleeding (CRB) remains an adverse outcome of anticoagulation for treatment of...
Monocarboxylate transporter 1 deficient donor T cells rewire metabolism and ameliorate aGVHD lethality
Abstract Introduction Allogeneic hematopoietic stem cell transplantation is limited by complications, including acute gr...
A prospective, single-arm, multicenter clinical study on the efficacy and safety of romiplostim N01 in acclerating platelet engraftment after autologous hematopoietic stem cell transplantation
Abstract Background and Significance: Autologous hematopoietic stem cell transplantation (ASCT) remains a cornerstone of consolidated or sal...
Predicting mortality in ICU patients with acute leukemias: A new risk score
Abstract Introduction: Mortality among patients with hematologic malignancies admitted to the intensive care unit (ICU) ranges from 19% to 8...
CD123-targeted radiotheranostics of Acute Myeloid Leukemia with 89Zr/177Lu-labeled pivekimab
Abstract Introduction CD123, the interleukin-3 receptor alpha chain, is highly-expressed on AML blasts and stem cells but less on normal cou...
National landscape of real-world pediatric blinatumomab care delivery in the United States: A report from the Children's Oncology Group
Abstract Introduction: The Children's Oncology Group (COG) Trial AALL1731 demonstrated a remarkable reduction in relapse risk with the addit...
Safety and efficacy of ibrutinib as a first line agent for Mantle Cell Lymphoma : A systematic review and meta-analysis
Abstract Background Mantle cell lymphoma (MCL) accounts for approximately 5% of all non-Hodgkin lymphomas and is charact...
Novel bispecific epitope anti-CD5 nanobody CAR-T cells for refractory or relapsed T-cell malignancies
Abstract Introduction: Due to the lack of effective therapeutic approaches, refractory/relapse (r/r) aggressive T-cell lymphomas have poor p...
Residual mutations in epigenetic modifiers are associated with poor prognosis and high relapse rate in Acute Myeloid Leukemia
Abstract Background Genetic mutations play a crucial role in the development and progression of Acute Myeloid Leukemia (AML), impacting trea...
Successful retreatment of PNH with switch to ravulizumab and add-on danicopan after experiencing breakthrough hemolysis on pegcetacoplan: A case report
Abstract Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder caused by uncontrolled terminal complement act...
Hematopoietic stem cell transplantation with reduced toxicity myeloablative conditioning regimen for children and adults with sickle cell disease: A brazilian single center experience.
Abstract Background: Sickle cell disease (SCD), characterized by vaso-occlusive crises, hemolysis, endothelial damage, and chronic inflammat...
Morbidities in β-thalassemia intermedia across the spectrum of disease severity: A nationwide study in Türkiye
Abstract Introduction Accumulated data show that anemia caused by ineffective erythropoiesis and iron overload is linked...
Cost-effectiveness of frontline blinatumomab in children with standard-risk B-cell acute lymphoblastic leukemia in Ontario, Canada
Abstract Introduction: The Children's Oncology Group trial AALL1731 (Gupta, NEJM 2025) investigated the addition of the bispecific T-cell en...
Biomarkers of ineffective erythropoiesis in patients with transfusion- dependent thalassemia
Abstract Introduction Transfusion-dependent thalassemia (TDT) is the prototype of ineffective erythropoiesis (IE)-associ...
Consensus on cytokine release syndrome (CRS) monitoring practices: A Delphi approach
Abstract Background Cytokine release syndrome (CRS) is a well-known and potentially fatal side effect of T cell redirecting therapy includin...
Transcriptional and splicing dysregulation by U2AF1 mutations contribute to inflammatory and migratory alterations in MDS
Abstract Recent genomic analyses have revealed that mutations in RNA splicing factors—including SF3B1, SRSF2, U2AF1, and ZRSR2—are among the...
CRS-RS.5p predictive model informs risk stratification and cytokine release syndrome management following glofitamab treatment in patients with relapsed or refractory diffuse large B-cell lymphoma
Abstract Background:Glofitamab is a CD20xCD3 T-cell engaging bispecific antibody with a novel 2:1 (CD20:CD3) format, which redirects T cells...
Budget impact of fixed duration acalabrutinib in combination with venetoclax in previously untreated chronic lymphocytic leukemia patients in the United States
Abstract INTRODUCTION: Chronic lymphocytic leukemia (CLL) has seen significant therapeutic advances with targeted Bruton's tyrosine kinase (...
MSC affect the sensitivity of CML cells to TKIs through mitochondrial transfered via tunneling nanotubes
Abstract Tyrosine kinase inhibitors (TKIs) are highly effective in treating chronic myeloid leukemia (CML), but drug resistance remains a si...
Serum cholesterol levels define an inverted u-shaped relationship with PBSC mobilization and immune balance in healthy donors
Abstract Background: Peripheral blood stem cell (PBSC) mobilization with granulocyte colony-stimulating factor (G-CSF) is the standard appro...
Pre-HCT creatinine defines sex-specific risk for severe TMA after allogeneic transplantation: A report from the MIDAS consortium.
Abstract INTRODUCTION: Severe transplant-associated thrombotic microangiopathy (TMA) is a serious complication of allogeneic hematopoietic c...