Blood
Articles in this Issue
Post-transplant cyclophosphamide (PTCy) versus other graft-versus-host disease prophylaxis strategies in reduced intensity allogeneic stem cell transplantation from related and matched unrelated donors in patients with acute myeloid leukemia and myelodysplastic syndromes: A study from the french society of bone marrow transplantation (SFGM-TC) registry
Abstract Graft-versus-host disease (GVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantati...
CD7 chimeric antigen receptor T cells for relapsed/refractory T-cell lymphomas: Single-arm, open-label, phase I study
Abstract Background: The prognosis of refractory/relapsed T-cell lymphoma is extremely poor, especially for the patients who failed to allog...
Long-term transfusion-free duration and impact on transfusion-related burdens: Results from the ongoing ENERGIZE-T open-label extension study of mitapivat in transfusion-dependent alpha- or beta-thalassemia
Abstract Introduction: While regular transfusions and iron chelators have improved survival and outcomes in individuals with thalassemia, th...
Elucidating gene alterations driving hematopoietic dysfunction in PNH via patient-derived ips cell modeling and whole-genome sequencing
Abstract Introduction Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, life-threatening hematologic disorder caused...
Unconventional mechanism of estrogen-induced thrombosis: The role of tissue factor and non-canonical pathways
Abstract Venous thromboembolism (VTE) is the third leading cause of cardiovascular mortality in the U.S., affecting ~900,000 individuals and...
Long-term outcomes, survival predictors and up-front treatment patterns in 568 elderly diffuse large b-cell lymphoma patients from LATAM: Is R-CHOP still the first choice for treating patients older than 60 years?
Abstract Introduction: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, occurring preferentially in...
Prognostic impact of molecular genetic and cytogenetic alterations in newly diagnosed acute myeloid leukemia treated with azacitidine and venetoclax: A real-world cohort study
Abstract Introduction:Azacitidine and venetoclax (Aza-Ven) is the standard of care for older or unfit patients (pts) with newly diagnosed AM...
A randomized phase 2 trial of CPX-351 vs. CLAG-m (Cladribine, High-Dose Cytarabine, G-CSF, and Mitoxantrone) in medically less-fit adults with previously untreated acute myeloid leukemia (AML) or other high-grade myeloid neoplasms
Abstract Background: While treatment options have significantly expanded for medically less-fit adults with newly diagnosed AML over the las...
A myeloid transcriptional signature stratifies outcomes in newly diagnosed ETP-ALL
Abstract Background T-cell acute lymphoblastic leukemia (T-ALL) accounts for ~25% of adult ALL and is classified by immunophenotypic (IP) ma...
Azacitidine (AZA) and venetoclax (VEN) combination for the treatment of immune mediate inflammatory diseases (IMID) associated with myeloid neoplasms (MN)
Abstract Background: IMID occurring in patients with MN, particularly studied in France by our MINHEMON group, are associated with substanti...
De novo secondary central nervous system lymphoma: A real-world cohort study over two decades
Abstract Secondary central nervous system lymphoma (SCNSL) involves CNS spread of systemic lymphoma, occurring at diagnosis (de novo) or at...
Spanish real-life practice confirms zanubrutinib as a safe and effective option in relapsed or refractory marginal zone lymphoma: Results of a cohort of 118 patients on behalf of GELTAMO.
Abstract Introduction: There is no established standard of care for relapsed or refractory (R/R) marginal zone lymphoma...
Sickle cell disease in europe: A cross-border real-world data analysis from the radeep registry
Abstract Introduction Advances in understanding the pathophysiology and clinical heterogeneity of sickle cell disease (S...
Development and validation of a novel pathologically-based prognostic model for primary central nervous system lymphoma
Abstract Background: Although the IELSG and MSKCC prognostic scoring systems for PCNSL are widely used, their clinical applicability remains...
Valemetostat monotherapy in patients with relapsed or refractory B-cell lymphoma: Final results of the Phase 2 valym study from the lysa
Abstract Introduction. B-cell lymphomas comprise a broad spectrum of diseases, with clinical courses ranging from frequently relapsing indol...
Artificial intelligence-based diagnosis of myelodysplastic syndromes/neoplasms using bone marrow
Abstract Background: Accurate diagnosis of myelodysplastic syndromes (MDS) relies on hematopathologist evaluation of bone marrow (BM) specim...
Serum ferritin changes in iptacopan-treated patients with paroxysmal nocturnal hemoglobinuria
Abstract Introduction: Patients with paroxysmal nocturnal hemoglobinuria (PNH) often develop iron deficiency (ID) due to chronic intravascul...
Tafasitamab-containing regimens in relapsed/refractory diffuse large B-cell lymphoma: A real-world retrospective case series
Abstract Introduction: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma (Br J Haematol 2024;205(6):2...
Immune reconstitution after venetoclax-based treatments in CLL
Abstract Background: Chronic lymphocytic leukemia (CLL)-associated hypogammaglobulinemia is well-established. A degree of humoral immune rec...
IL-2 mutein-mediated improvement of CAR T function in Relapsed/Refractory diffuse B cell lymphoma
Abstract Although chimeric antigen receptor (CAR)-T cell therapy has transformed the treatment landscape of B-cell malignancies, many patien...
Utilization and outcome disparities in autologous hematopoietic stem celltransplantation among patients with multiple myeloma in the United States
Abstract Background: Hematopoietic cell transplantation (HCT) is a complex and cost-intensive, but life-saving procedure...
Real-world treatment and safety outcomes of patients with Mantle Cell Lymphoma in the United States
Abstract Background: Mantle cell lymphoma (MCL) is an aggressive and rare form of B-cell non-Hodgkin's (NHL) lymphoma and accounts for 5-10...
Efficacy of venetoclax in the treatment of relapsed/refractory light-chain amyloidosis
Abstract Background Venetoclax (Ven) has shown promising efficacy in light-chain (AL) amyloidosis, particularly among patients with t(11;14)...
Real-world application of AI in expediting paroxysmal nocturnal hemoglobinuria diagnosis
Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, chronic, potentially life-threatening hematological disorder that is associate...
Inflammatory Waldenström macroglobulinemia is associated with monocyte dysregulation and IL-1β production
Abstract Background Waldenström macroglobulinemia (WM) is a rare, indolent B-cell neoplasm characterized by bone marrow...