Blood
Articles in this Issue
Exploring experiences and perceptions of fertility and reproductive technology among people with sickle cell disease
Abstract Background: Sickle cell disease (SCD) is an autosomal recessive inherited blood disorder that impacts about 100,000 people in the U...
Monotherapy update from Phase 1 portion in Phase1/2 trial of the menin-MLL inhibitor enzomenib (DSP-5336) in patients with relapsed or refractory acute leukemia
Abstract Introduction: Enzomenib (ENZO, DSP-5336) is an investigational, oral small molecule inhibitor of the menin and KMT2A protein intera...
Improvement of signs and symptoms of vulvovaginal chronic graft-versus-host disease with non-ablative radiofrequency therapy
Abstract Introduction: Chronic graft-versus-host disease (cGVHD) is a major cause of late morbidity and mortality following allogeneic hemat...
Clinical outcomes associated with serological subsets of heparin-induced thrombocytopenia
Abstract Background: Heparin Induced Thrombocytopenia (HIT) is an immune-mediated drug reaction classically characterized by platelet activa...
Phosphatidylserine-rich platelet blebs enhance hemostasis after mucous membrane injury but not after skin or vascular injury: Studies with ANO6-deficient mice
Abstract Platelets expose high levels of phosphatidylserine (PS) on large membrane blebs in response to strong agonists. These annexin A5-po...
Genetic risk model to predict outcomes for AML treated with HMA and venetoclax
Abstract Introduction Existing genetic risk models in acute myeloid leukemia (AML) were developed primarily in patients treated with intensi...
Efficacy and safety of zanubrutinib combined with anti-CD20 monoclonal antibody-based regimens as first-line therapy in high-risk follicular lymphoma and marginal zone lymphoma: A single-arm retrospective study
Abstract The incidence of indolent B-cell lymphomas, particularly follicular lymphoma (FL) and marginal zone lymphoma (MZL), continues to ri...
Identifying AML patients most likely to benefit from venetoclax using apoptotic gene ratios
Abstract Venetoclax is widely used to treat patients with acute myeloid leukemia (AML) who are older or those who are not candidates for int...
Deciphering tph cells as prognostic drivers of angioimmunoblastic T-cell lymphoma
Abstract INTRODUCTION Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive malignancy derived from follicular helper T (Tfh) cells, ch...
Real-world efficacy and safety of teclistamab in relapsed or refractory multiple myeloma: Results from 87 patients treated by the polish myeloma group
Abstract BACKGROUND: Multiple myeloma (MM) is a hematologic malignancy with limited treatment options for patients with relapsed/refractory...
Distribution and risk for bleeding in patients with cancer by anticoagulant therapy exposure
Abstract Introduction: Available data suggests that the global risk of bleeding in persons with cancer is high [Englisch et al. Blood 2024]....
Clinical outcomes associated with conditioning regimens in patients with primary central nervous system lymphoma undergoing consolidation autologous stem cell transplantation
Abstract Background: Primary central nervous system lymphoma (PCNSL) is a rare, aggressive extra-nodal non-Hodgkin lymphoma confined to the...
First-in-human randomized placebo-controlled Phase 1 study of RPT1G, a novel hyperbolic NAMPT inhibitor for use in acute leukemias: Safety, pharmacokinetics, and pharmacodynamics in healthy volunteers
Abstract Background. Nicotinamide phosphoribosyltransferase (NAMPT) is a well-known and extensively studied target in oncology. NAMPT cataly...
Animated Patient's guide to Acute Myeloid Leukemia: Assessing patient understanding, shared decision-making, and health outcomes.
Abstract Background: Acute myeloid leukemia (AML) patient education resources that address barriers to health literacy, elucidate the many c...
Single-cell transcriptomics of AL amyloidosis reveals pathogenic mechanisms, immune interactions and altered clonal and polyclonal plasma cell phenotypes
Abstract Background: Systemic light chain (AL) amyloidosis is caused by clonal expansion of plasma cells (PCs) secreting misfolded monoclonal...
Older donor age is not associated with inferior survival in contemporary haploidentical transplantation
Abstract Background: Data regarding the association of donor age with haploidentical hematopoietic stem cell transplant...
Allogeneic CD19-directed CAR T-cell therapy derived from umbilical cord blood for relapsed acute lymphoblastic leukemia
Abstract Background: Chimeric antigen receptor (CAR) T-cell therapy is an effective treatment for relapsed and refractory acute lymphoblasti...
How should fever be managed in adults with sickle cell disease? a quality metrics study and mapping of essential elements to improve care delivery
Abstract Background: Adults with sickle cell disease (SCD) are at high risk for life-threatening bacterial infections due to functional or a...
Prophylactic and preemptive donor lymphocyte infusion (DLI) improves outcomes in refractory AML undergoing allogeneic hematopoietic cell transplantation: A single-center retrospective Study from Latin America
Abstract Relapse remains the leading cause of treatment failure in patients with refractory acute myeloid leukemia (AML) undergoing allogene...
Allogeneic hematopoietic stem cell transplantation in CR1 and continuous Chemotherapy plus FLT3-targeting inhibitor had comparable outcomes in FLT3-ITD mutated Acute Myeloid Leukemia with negative measurable residual disease
Abstract Objectives To compare the outcomes of FLT3-ITD mutated AML patients who underwent allo-HSCT in first complete remission (CR1) with...
Kte-X19 in relapsed or refractory adult B-cell acute lymphoblastic leukemia in the Chinese population: 6-month analysis of a phase II multicenter trial
Abstract Background: Relapsed or refractory B-precursor acute lymphoblastic leukemia (R/R B-ALL) in adults is associated with an unfavorable...
Anti-CD38 immunotherapy assay and monitoring in patients with multiple myeloma: A monocentric pilot study
Abstract Introduction Daratumumab is a humanized monoclonal antibody targeting surface molecule CD38 on myeloma cells. It is widely used due...
Cytogenetic testing in newly diagnosed multiple myeloma (NDMM): Real world evidence of adverse outcomes for high risk groups.
Abstract Aim: To compare baseline characteristics, treatments and outcomes in newly diagnosed multiple myeloma (NDMM) pa...
Lusutrombopag improves platelet engraftment after autologous haematopoietic stem cell transplantation in multiple myeloma: A single-centre retrospective study
Abstract Abstract Title: Lusutrombopag Improves Platelet Engraftment after Autologous Haematopoietic Stem Cell Transplan...
EZH2 inactivation cooperates with HOXA9 to induce leukemic transformation of human t-cell progenitors and sustain high-risk subsets of early t-cell precursor acute lymphoblastic leukemia (ETP-ALL)
Abstract Early T-cell precursor (ETP) acute lymphoblastic leukemia/lymphoma (ALL) is an aggressive hematological malignancy characterized by...