Blood
Articles in this Issue
A perturb-seq map of a differentiation hub reveals synergistic vulnerabilities in KMT2A-rearranged AML
Abstract Introduction: KMT2A-rearranged (KMT2A-r) acute myeloid leukemia (AML) is characterized by epigenetic dependencies, yet it often rem...
Geriatric assessment in hematology (GAH) scale for survival prognostication and early treatment discontinuation in older adults: Final results from the spanish hematogeriatric registry
Abstract Introduction: Comprehensive geriatric assessment (CGA) is the “gold standard” for determining frailty in older patients with hemato...
Peripheral blast count at apheresis as a risk factor for survival following tisagenlecleucel in children and young adults
Abstract Precursor B-cell acute lymphoblastic leukemia (B-ALL) is the most common childhood malignancy. Relapsed or refractory (R/R) B-ALL c...
Impact of antibiotic exposure on CAR-T cell therapy outcomes: Analysis in multiple Myeloma and lymphoma
Abstract Background: The gut microbiome is known to play a significant role in cancer immunotherapy. Antibiotic use can disrupt the intestina...
Impact of new or worsening anemia and thrombocytopenia on clinical outcomes in JAK inhibitor–naive myelofibrosis patients treated with ruxolitinib
Abstract Introduction: Myelofibrosis (MF) is characterized by splenomegaly, constitutional symptoms, and cytopenias such as anemia and thromb...
Fat pad biopsy versus target organ biopsy in systemic AL amyloidosis detection
Abstract Fat pad biopsies (bx) are routinely used in the diagnostic work-up for AL amyloidosis due to their feasibility and low complication...
Distinct and non-overlapping epigenetic signatures differentiate MPN subtypes and reveal hydroxyurea-induced remodeling
Abstract Background Myeloproliferative neoplasms (MPNs) including polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis (...
Impact of ruxolitinib on corticosteroid treatment patterns in 1147 patients with chronic graft-versus-host disease in real-world practice in the United States: A long-term follow-up analysis
Abstract Background: Ruxolitinib (RUX) is an oral, selective Janus kinase (JAK)1/JAK2 inhibitor approved for chronic graft-versus-host disea...
Target antigen density may impact clinical response in patients with relapsed/refractory multiple myeloma undergoing treatment with elotuzumab and belantamab mafodotin
Abstract Background: NCT05002816 is an ongoing phase Ib/II trial evaluating the safety, tolerability and preliminary efficacy of the unique...
Loss-of-function alterations in TRAF3 drive BTK/PLCG2-independent ibrutinib resistance in CLL
Abstract Bruton's tyrosine kinase inhibitors (BTKis) have transformed the treatment of Chronic Lymphocytic Leukemia (CLL), yet many patients...
Real-world changes in CLL treatment patterns following collaborative educational initiatives delivered in community settings
Abstract Background: Modern therapeutics in use for chronic lymphocytic leukemia (CLL), including covalent BTK inhibitors (cBTKi), time-limi...
Daunorubicin and cytarabine liposomal (CPX-351) plus glasdegib for newly diagnosed secondary Acute Myeloid Leukemia: Results of University of California hematologic malignancies consortium trial 1913
Abstract Intro Secondary acute myeloid leukemia (sAML) from antecedent hematologic disorders or prior cytotoxic therapy is associated with a...
Clinicopathological characteristics of high-grade B-cell lymphomas through Bone marrow evaluation
Abstract High-grade B-cell lymphoma (HGBCL) is primarily diagnosed and classified through tissue biopsy. However, in a small subset of cases...
Golcadomide (GOLCA), a potential, first-in-class, oral CELMoD™ agent, ± rituximab (R) in patients with Relapsed/Refractory follicular lymphoma (R/R FL): Phase 1/2 study extended follow-up Results
Abstract Introduction While outcomes in patients with R/R FL have improved with T-cell–redirecting treatments (e.g. CAR...
Adverse outcomes of acute pericarditis in patients with active multiple myeloma: Insights from a national inpatient cohort
Abstract Background: Current literature suggests that patients with hematologic malignancies are predisposed to poorer cardiovascular diseas...
Rural-urban disparities in survival rates in adult Hodgkin lymphoma: A population-based study
Abstract Introduction Hodgkin's lymphoma is known to have favorable survival outcomes; however, limited data exist regar...
Quality initiative in first-line chronic lymphocytic leukemia /small lymphocytic lymphoma assessing the use of 2nd generation BTKi therapy and impact on cardiac medical conditions patients experience on treatment
Abstract Background: Given the introduction of 2nd generation safer and more tolerable BTKis to treat first- line Chronic Lymphocytic Leukem...
A prospective study reveals feasibility and merits of drug profiling-guided precision therapy for children with high-risk leukemias
Abstract Introduction Children with relapsed or refractory acute leukemias have limited treatment options and portend a dismal prognosis. Fu...
Modification of post-trogocytosis effects to Enhance CAR-t cell persistence
Abstract Trogocytosis is currently defined as a rapid membrane exchange process that occurs during cell-cell contact. Although widely report...
Lbl-076, a first-in-class GPRC5DxCD38xCD3 trispecific T cell engager (TCE) for the treatment of relapsed/refractory multiple myeloma
Abstract Background: Despite significant therapeutic advancements, multiple myeloma (MM) remains incurable. Most patients ultimately relapse...
Older adults with multiple myeloma can drive CAR safely
Abstract Introduction: Multiple myeloma (MM) is a bone marrow malignancy that predominantly involves older adults. CAR-T is a highly effecti...
Increased risk of venous thromboembolism and hypertensive disorders during pregnancy in sickle cell disease patients: A meta-analysis focused on actionable outcomes
Abstract There is a paucity of evidence-based interventions to improve outcomes in pregnancy in sickle cell disease (SCD) patients despite a...
Causal role of gut microbiota in immune thrombocytopenia: A systematic review of mendelian randomization studies
Abstract Background Gut dysbiosis has been repeatedly linked to immune thrombocytopenia (ITP), but confounding and reverse causation hamper...
Lipid nanoparticle-based delivery of gene therapy targeting the RUNX1::RUNX1T1 fusion oncogene in acute myeloid leukemia
Abstract Acute myeloid leukemia (AML) with RUNX1::RUNX1T1 was one of the first types of AML to be defined by a translocation leading to the...
Redefining post-CD19 CAR T-cell surveillance with ctdna: Real-world insights from post- axi-cel and liso-cel therapy
Abstract Introduction: Circulating tumor DNA (ctDNA)-based measurable residual disease (MRD) assessment is a promising noninvasive biomarker...