Blood
Articles in this Issue
Morphology guided spatial transcriptomics to study topography of Hodgkin reed sternberg cells interaction with tumor microenvironment and its impact in defining risk of progression in classical Hodgkin lymphoma.
Abstract Introduction Classical Hodgkin Lymphoma (cHL) is one of the most manageable human cancers. The early identifica...
Comprehensive analysis of bridging to CAR-T cell therapy in large B-cell lymphoma with conventional treatment or the CD3xCD20 bispecific antibody glofitamab
Abstract Abstract Introduction Despite evidence supporting the importance of remission prior to CAR-T therapy in relapsed/refractory large B-...
A real world study of inotuzumab ozogamicin for the treatment of B-cell acute lymphoblastic leukemia: Multi-center result from SH-ALL group
Abstract Background： Inotuzumab ozogamicin(INO) is an antibody-drug conjugate for CD22-positive acute B-cell lymphoblastic leukemia(B-ALL)....
Real-world safety and discontinuation patterns of ibrutinib in B-cell malignancies: A 9-year experience from Qatar
Abstract Background: Ibrutinib, the first approved Bruton's tyrosine kinase inhibitor, is used in the management of first-line and relapsed/...
Ruxolitinib combined with P-gemox in adult patients with newly diagnosed aggressive natural killer cell leukemia
Abstract Background Aggressive natural killer cell leukemia (ANKL) is a rare and fulminant hematologic malignancy characterized by a median...
Treatment patterns and outcomes of primary central nervous system lymphoma treated with high-dose methotrexate with or without autologous stem cell transplantation or whole brain radiation in the rea-world setting
Abstract Introduction: Primary central nervous system lymphoma (PCNSL) is a rare non-Hodgkin lymphoma with a high relapse risk in the absenc...
Deciphering the IKZF1 and MAP4K2 protein interactome in RASMut multiple myeloma reveals a novel regulatory pathway of IKZF1
Abstract Background: RAS pathway mutations are common in multiple myeloma (MM) and linked to MAP4K2 upregulation, a potential therapeutic ta...
Olverembatinib-mediated deep remission improves allogeneic stem cell transplantation outcome in patients with blast crisis chronic myeloid leukemia: First real-world practice report
Abstract Introduction: Despite therapeutic advances, blast crisis chronic myeloid leukemia (BC-CML) remains poor outcomes. Long-term surviva...
Allogeneic HSC and regulatory T cell (Orca-T) engineered cell therapy following reduced intensity conditioning: Results of a single center Phase 1 study
Abstract Introduction: The combination of Orca-T, an investigational allogeneic T-cell immunotherapy, with myeloablative conditioning (MAC)...
T-cell tolerant fraction as a predictor of graft-versus-host disease in murine and human allogeneic hematopoietic cell transplantation
Abstract Background: Allogeneic hematopoietic cell transplantation (HCT) is curative in a variety of hematologic malignancies, through recon...
Molecular response of Acute Myeloid Leukemia to induction with CPX-351 and its impact on prognosis
Abstract Background: CPX-351 has emerged as a preferred induction therapy for patients (pts.) with acute myeloid leukemi...
The impact of high-grade B-cell lymphoma morphology compared with diffuse large B-cell lymphoma in a cohort from bra-DLBCL, a multicenter, real-world study from Brazil
Abstract AbstractIntroduction High-grade B-cell lymphoma (HGBL), not otherwise specified (NOS), is an aggressive B-cell...
Clinical and genetic features of primary hemophagocytic lymphohistiocytosis: A single-center analysis
Abstract Background and Purpose Primary hemophagocytic syndrome (pHLH) is a rare hereditary immunodeficiency disease. At...
Caplacizumab as a pre-emptive therapy in thrombotic thrombocytopenic purpura: A proactive strategy to reduce morbidity
Abstract Introduction: Acquired Thrombotic thrombocytopenic purpura (aTTP) is a life-threatening condition in which prompt treatment can sig...
Real-world evidence demonstrates superior overall survival and favorable safety of avapritinib over midostaurin in newly diagnosed advanced systemic mastocytosis
Abstract Background: Advanced systemic mastocytosis (AdvSM), a hematologic malignancy driven by activating KIT mutations...
Does intensive consolidation confer a clinical advantage over continued less intensive therapy in elderly patients with Acute Myeloid Leukemia in first remission following azacitidine plus venetoclax induction?
Abstract Background The combination of venetoclax with azacitidine (VEN-AZA) has been widely utilized to treat newly diagnosed patients with...
Dysregulated proteasome proteostasis acts as a driver of light chain amyloidosis
Abstract Light chain amyloidosis (AL) is the most common subtype of systemic amyloidosis in the United States, with 4,500 new cased diagnose...
Baricitinib reveals LGALS3BP as a novel pathogenic factor and therapeutic target in immune thrombocytopenia
Abstract Introduction Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by immune-mediated platelet destruction...
Pre-CAR-T pulmonary function test and respiratory comorbidities have limited predictive value for survival, toxicities, and respiratory complications
Abstract Introduction Pre-hematopoietic cell transplantation pulmonary function tests (PFT) are routinely performed for...
Co-targeting menin and RAS in KMT2A-r/NPM1c AML with activated RTK//RAS/MAPK signaling
Abstract Alteration in hematopoietic transcription programming and activation of signaling transduction pathways frequently co-occur to driv...
Biallelic TP53 alterations predict poorer survival in Mantle Cell Lymphoma: Insights from a national real-world cohort high-touch project
Abstract Background: Mantle Cell Lymphoma (MCL) is an uncommon B-cell lymphoma with a heterogenous disease course. While relapse is common,...
Characteristics of patients with Relapsed/Refractory multiple myeloma (RRMM) in europe and the US
Abstract Introduction: Multiple myeloma (MM) significantly contributes to global disease burden. To facilitate tailoring of treatment strate...
When growth hormone deficiency isn't the answer: A case of gaucher disease
Abstract Background : Gaucher disease (GD) is a rare autosomal recessive lysosomal storage disorder caused by mutations in the GBA gene. Thi...
High event-free (EFS) and overall survival (OS) after non-total body irradiation (TBI) conditioning and allogeneic hematopoietic cell transplantation (HCT) in next-generation-sequencing minimal residual disease (NGS-MRD) negative B-acute lymphoblastic leukemia (B-ALL): Results from the EndRAD trial (PTCTC ONC1701)
Abstract Introduction: HCT is an established curative treatment for children, adolescents, and young adults (CAYA) with high-risk/relapsed B...
A prospective, multicenter, randomized, controlled clinical trial comparing polatuzumab vedotin, zanubrutinib, lenalidomide, and rituximab (Pola-ZR2) versus zanubrutinib, lenalidomide, and rituximab (ZR2) in the treatment of previously untreated, elderly patients with diffuse large B-cell lymphoma (NCT06522555)
Abstract Background: Elderly patients with diffuse large B-cell lymphoma (DLBCL) often tolerate standard chemoimmunotherapy poorly, emphasizi...