Blood
Articles in this Issue
Intermediate and high-risk clonal hematopoiesis in germline predisposition families
Abstract INTRODUCTION Approximately 10% of adults diagnosed with myelodysplastic neoplasms (MDS) or acute myeloid leukem...
Risk stratification, prognostic factors, outcomes and quality of life assessment in patients with primary polycythemia
Abstract Background: Polycythemia Vera(PV) is a chronic myeloproliferative neoplasm (MPN) characterized by clonal erythrocytosis. In the con...
Pregnancy outcomes among women with sickle cell disease: A propensity score-matched analysis approach using the national inpatient sample (2017-2022)
Abstract Introduction: Pregnancies complicated by sickle cell disease (SCD) are associated with significant maternal and fetal risks. While...
MMF is associated with higher non-relapse mortality and inferior survival in AML/MDS patients receiving peripheral blood matched allogeneic stem cell transplantation with post-transplant cyclophosphamide based gvhd prophylaxis
Abstract Introduction. Results of our previous studies have suggested that the use of mycophenolate mofetil (MMF) for graft-versus-host dise...
Genomic and transcriptomic signatures of extramedullary multiple myeloma reveal possible drivers of therapeutic resistance
Abstract Background: Extramedullary disease (EMD) is an aggressive manifestation of multiple myeloma (MM) associated with inferior overall s...
Acute Myeloid Leukemia (AML) with TP53 alteration and outcomes after allogeneic hematopoietic stem cell transplantation: A CIBMTR registry study
Abstract Background: Acute myeloid leukemia (AML) with TP53 alteration (TP53alt), including deletion (TP53del) detected by cytogenetics (CG)...
Serum exo-miR584-5p mediates drug resistance in diffuse large B-cell lymphoma by upregulating the drug metabolism-CYP450 pathway, promoting high P450 expression, and remodling its intracellular localization.
Abstract Background Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma. Although stan...
Hematobot: Retrieval‑augmented large language model‑based assistants for therapy, toxicity and frailty management in multiple myeloma by the spanish society of hematology and hemotherapy (SEHH)
Abstract Background Generative artificial intelligence (GenAI) powered by large language models (LLMs) and retrieval-aug...
Patient-derived amyloidogenic light chain triggers cardiovascular toxicity In Vivo and reveals ICAM-1 as a novel potential biomarker in patients with AL amyloidosis
Abstract Background and aims: In light chain (AL), the circulating immunoglobulin light chains (LCs) have been suggested to provoke cardioto...
Impact of angiotensin converting enzyme inhibitors (ACEis) and angiotensin receptor blockers (ARB) on tumor lysis syndrome, acute kidney injury, and rasburicase use in patients undergoing chemotherapy for hematologic malignancies
Abstract Introduction Angiotensin-converting enzyme inhibitors (ACEis) and angiotensin receptor blockers (ARBs) are wide...
Asciminib versus second generation TKI in newly diagnosed chronic Phase chronic myeloid leukemia: A meta analysis
Abstract Introduction: Chronic Myeloid Leukemia (CML) is categorized as a myeloproliferative neoplasm, with a global annual incidence of app...
Association between momelotinib exposure and hemoglobin improvement in patients with myelofibrosis and anemia: An exposure-response and time-to-event analysis
Abstract Introduction: Anemia is a prevalent and progressive manifestation of myelofibrosis (MF) with substantial impacts on patient quality...
Clinical outcomes in spliceosome-mutant myelodysplastic neoplasms and Acute Myeloid Leukemia
Abstract Spliceosomes facilitate the removal of non-coding introns from precursor messenger RNA via a macromolecular complex to form mature...
Lisocabtagene maraleucel (liso-cel) demonstrates superior efficacy across inflammatory risk subgroups in second-line (2L) large B-cell lymphoma (LBCL): A retrospective analysis of the TRANSFORM study
Abstract Introduction: The InflaMix (INFLAmmation MIXture) model classifies the disease of patients with R/R LBCL as inflamed or noninflamed...
Ectopic EBV infection in T cells following allogeneic hematopoietic stem cell transplantation: Clinical outcomes and immunological characterization
Abstract Background: Epstein-Barr virus (EBV) infection is a common complication after allogeneic hematopoietic stem cell transplantation (a...
Epithelial growth factor like-7 (EGFL7) regulates hematopoiesis stem cell (HSC) activation via AP-1 suppression
Abstract Limitations in the availability and expansion of hematopoietic stem cell (HSC) are a critical barrier for treating hematological di...
Bleeding disorder of unknown cause: Is there a role for expanded platelet testing?
Abstract Introduction: Only 30% of patients (pts) presenting with abnormal bleeding symptoms receive a clear diagnosis,...
Belantamab mafodotin (belamaf) in combination with bortezomib, lenalidomide, and dexamethasone (VRd) for patients (pts) with transplant-ineligible (TI) newly diagnosed multiple myeloma (NDMM): A focus on treatment efficacy and management/resolution of ocular events in the Phase 1 dreamm-9 study
Abstract Introduction: Belamaf is an antibody-drug conjugate approved in multiple countries as part of combination regimens for relapsed/ref...
Time-stratified risk of second primary solid malignancies among follicular lymphoma survivors in the United States
Abstract Introduction: Survivors of follicular lymphoma (FL) face an elevated risk of developing second primary malignancies (SPMs). The ris...
Treatment patterns in patients aged 80+ years with LBCL: Propensity score analysis reveals comparable outcomes between R-CHOP and R-mini-CHOP
Abstract Introduction Although chemo-free regimens are increasingly used in elderly patients with large B-cell lymphoma (LBCL), most still r...
Treatment patterns and clinical outcomes in patients with lower-risk Myelodysplastic Syndromes rreated with first-line luspatercept: Findings from a medical record review in France and Germany
Abstract Background: In patients with lower-risk myelodysplastic syndrome (LR-MDS), luspatercept has demonstrated significant clinical benef...
CFP1 controls H3K4me3-mediated chromatin architecture to promote v(D)j recombination in early B cell development
Abstract V(D)J recombination is a fundamental process in B lymphocyte development that generates a diverse immunoglobulin (Ig) repertoire th...
A FXIa-modified clot waveform analysis for estimation of factor VIII level and emicizumab concentration in hemophilia A
Abstract Background Hemophilia A treatment options include factor VIII (FVIII) substitution and non-factor therapies, li...
A single-center retrospective study of ixazomib-based regimens as maintenance therapy in newly diagnosed multiple myeloma
Abstract Background Multiple myeloma (MM) remains incurable, and maintenance therapy is critical for sustaining remission and improving surv...
Community health worker contacts for high utilizer vs. other sickle cell patients in an adult sickle cell disease medical home
Abstract Background Medical center-based Community Health Workers, also known as Patient Navigators (PNs), often increase patient engagement...