Blood
Articles in this Issue
The research on the immune microenvironment of patients with relapse or refractory diffuse large b faced drug resistance to CD20/CD3 bispecific antibodies
Abstract Introduction: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma (NHL), which is highly hetero...
Gene-regulatory axes of diffuse large B-cell lymphoma subtypes
Abstract Introduction: Diffuse large B-cell lymphoma (DLBCL) is stratified into genetic subtypes (MCD, BN2, A53, N1, EZB, ST2) that differ i...
primary mediastinal B-cell lymphoma: Survival trends and statistics
Abstract Introduction Primary mediastinal B cell lymphoma (PMBCL) is a rare subtype of large Bcell lymphoma. It accounts for approximately 5...
Superior efficacy and persistence of Orca-T-allogeneic CAR19/22 versus autologous CAR19/22 in high-risk adult B-ALL
Abstract Background: Adults with high-risk (HR), relapsed/refractory (r/r) B-ALL who receive CAR-T often require consolidative allogeneic HC...
PHF19 inhibition increases IMiDs sensitivity by epigenetically regulating IRF4 and MYC in multiple myeloma
Abstract Immunomodulatory drugs (IMiDs) are a cornerstone of multiple myeloma (MM) therapy. However, drug resistance remains a major obstacl...
Aberrant clonal plasma cells bypass the proteasome proteostasis by endoplasmic reticulum associated protein degradation
Abstract Dysregulated proteostasis is the hallmark of clonal plasma cell disorders (PCD), including amyloidosis (AL), monoclonal gammopathy...
Representation of older adults in registrational trials associated with therapeutic approvals in follicular lymphoma
Abstract Introduction: Follicular lymphoma (FL) is a disease of older adults (age≥65 years, yrs) (OA) with a median age at diagnosis of 64 y...
Total marrow irradiation based conditioning for allogeneic hematopoietic stem cell transplantation in elderly or frail patients with hematological malignancies: A single center analysis
Abstract Background：Allogeneic hematopoietic stem-cell transplantation (allo-HSCT) remains the only potentially curative therapy for many h...
Efficacy and safety of pegylated interferon alfa-2b in myeloproliferative neoplasms: A multicenter retrospective study of 210 patients
Abstract Background： Pegylated interferon alfa-2b (Peg-IFN-α-2b) may induce molecular remission in myeloproliferative neoplasms (MPN) throu...
Comparative CRS risk across CAR-T constructs in DLBCL in real-world cohorts
Abstract Background Cytokine release syndrome (CRS) is a common and potentially life-threatening toxicity associated wit...
Real-world safety and efficacy of avatrombopag in adults with immune thrombocytopenia: A systematic review and meta-analysis.
Abstract Introduction Primary immune thrombocytopenia (ITP) is classically associated with bleeding risk but also presen...
Impact of HIV status on clinical outcomes in Hodgkin lymphoma: A national database study
Abstract Background: Patients with Human Immunodeficiecy Virus (HIV) are at increased risk for Hodgkin Lymphoma (HL). Re...
A phase 1b trial of the EZH2 inhibitor tazemetostat combined with CAR T cell therapy in B cell lymphomas
Abstract Background: Chimeric antigen receptor (CAR) T cells have remarkable efficacy in B cell lymphomas, but most patients eventually rela...
CAR-t cell therapy in TP53-mutated CNS lymphoma: Overcoming a high-risk genetic barrier
Abstract Background: Central nervous system lymphoma (CNSL) is a rare but aggressive subtype of lymphoma that presents significant therapeuti...
Exploratory study: Iron trends in aging women with sickle cell disease
Abstract A subset of individuals with sickle cell disease (SCD) develop progressive iron overload with age due to increased lifetime blood t...
Characterising the leukaemic microenvironment in a mouse model of infant AML with prenatal KMT2A-MLLT3 expression
Abstract Infant acute myeloid leukaemia (AML) is an aggressive form of paediatric leukaemia diagnosed in children under two years of age. In...
Plasmapheresis facilitates soluble BCMA clearance and contributes to reversing primary resistance to anti-BCMA immunotherapy in multiple myeloma
Abstract Introduction: Despite potent efficacy of bispecific antibodies against the B-cell maturation antigen (BCMA) in multiple myeloma (MM...
Safety of lumbar puncture in adult patients with acute lymphoblastic leukemia and thrombocytopenia: A retrospective study
Abstract Introduction: Acute lymphoblastic leukemia (ALL) requires lumbar punctures (LPs) for central nervous system (CNS) diagnosis and tre...
Adenosine pathway as a therapeutic target in diffuse large B cell lymphoma
Abstract Purine metabolites have emerged as important mediators of B cell function and tumor immunity. However, their effect on B-cell lymph...
Long-term follow-up reveals sustained benefit of dual CD19/CD22 CAR T-cell therapy alone or combined with autologous stem cell transplantation in TP53-altered relapsed/refractory B-cell non-Hodgkin lymphoma
Abstract Introduction TP53 alterations are recognized molecular markers of high-risk disease in patients with relapsed o...
Pre-existing clonal hematopoiesis in CAR-T recipients is not associated with increased immunotoxicity and inflammatory serum signatures
Abstract Introduction: Clonal hematopoiesis of indeterminate potential (CHiP) represents a myeloid precursor lesion described by the presenc...
Double-dose axicabtagene ciloleucel (Axi-Cel-2) as second-line therapy for high-risk relapsed or refractory large B-cell lymphoma (r/rLBCL): Interim results from a Phase 1b study
Abstract Background Axicabtagene ciloleucel(axi-cel) has improved outcomes in relapsed or refractory large B-cell lymphoma(r/rLBCL); however...
Efficacy, safety, and NGS analysis of orelabrutinib combined with obinutuzumab in untreated marginal zone lymphoma
Abstract Introduction Existing studies have demonstrated that combining BTK inhibitors with anti-CD20 monoclonal antibodies yields favorable...
Phase 1b/2 study of axatilimab in combination with azacitidine in advanced Phase MPN, MDS/ MPN overlap and high-risk CMML
Abstract Background & Significance: Effective management strategies are urgently needed for patients (pts) with MDS/MPN overlap syndrome...
Assessment of the prognostic value of FDG PET-derived markers and responses in POLARIX
Abstract Background: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease and accurate outcome prediction is essential for optim...