Blood
Articles in this Issue
Artificial intelligence and machine learning applications in iron deficiency anemia: A systematic review (2015‑2025)
Abstract Background: Iron deficiency anemia (IDA) affects approximately 1.2 billion people worldwide, yet ferritin-based diagnosis is confou...
Targeting inflammation in sickle cell disease: Association of GLP-1 agonist use with improved survival and reduced sickle cell crisis and cardiopulmonary complications
Abstract Sickle cell disease (SCD) is a hereditary hemoglobinopathy characterized by chronic hemolysis, vaso-occlusion, and a systemic infla...
Impact of obesity on response to first line treatment in primary immune thrombocytopenia - data from Latin America population
Abstract Introduction Although Immune thrombocytopenia (ITP) natural history and treatment have been well characterized,...
Identify high-risk disease in multiple myeloma through single-cell transcriptomic detection of highly proliferative (PR) cells
Abstract Despite recent advances in multiple myeloma (MM) treatment, a subset of patients continues to experience early disease progression...
Optimal dose and duration of venetoclax for induction therapy in acute myeloid leukemia and myelodysplastic syndrome: A systematic review and meta-analysis
Abstract Background Venetoclax, a selective BCL-2 inhibitor, has become a key component of induction therapy for newly d...
Tailoring pediatric to adult care transition from high to low-resource settings: A user-centered design approach
Abstract Background Brazil is home to one of the largest populations of individuals with sickle cell disease (SCD) in the world, with an est...
Combinations of high risk cytogenetic events in multiple myeloma drive distinct immune remodeling patterns and worse outcomes
Abstract Introduction: Multiple Myeloma (MM) is a complex hematologic malignancy, where patients often display one or more potentially high...
Cervical cancer screening outcomes in adolescents and young adults with sickle cell disease age 21–29: A retrospective chart review
Abstract Background: Cervical cancer screening is essential for early detection and prevention, particularly among adole...
Blood heavy-metal levels and risk of hematologic cancer in u.S. adults: Nhanes 2021–2023
Abstract Blood Heavy-Metal Levels and Risk of Hematologic Cancer in U.S. Adults: NHANES 2021–2023 Background: Heavy meta...
MRD-guided ibrutinib plus venetoclax improves outcomes in CLL patients with TP53, ATM, or NOTCH1 aberrations compared to ibrutinib and FCR: Results from the Phase III NCRI FLAIR trial
Abstract Introduction: We have previously reported improved survival in patients (pts) with recurrent gene mutations following treatment wit...
Very low risk for secondary malignancies with btkis in Waldenström macroglobulinemia: A retrospective real-world multicenter study.
Abstract The prolonged survival of patients with Waldenström Macroglobulinemia (WM), together with the increasing use of chemoimmunotherapy...
Rhabdomyolysis in patients taking isocitrate dehydrogenase inhibitors for R/R Acute Myeloid Leukemia
Abstract Mutations in isocitrate dehydrogenase (IDH1, IDH2) are present in ~20% of adult patients with acute myeloid leukemia (AML) (Im, 201...
The ribosome biogenesis inhibitor CX-5461 increases platelet count in humans and enhances murine megakaryopoiesis
Abstract Treatment of sub-optimal platelet production and thrombocytopenia remains a major clinical challenge and thrombocytopenia is a comm...
Impact of renal impairment and lymphodepletion regimen on outcomes after CAR T-cell therapy in relapsed/refractory multiple myeloma
Abstract Introduction Chimeric Antigen Receptor (CAR) T cell therapy has revolutionized treatment for relapsed/refractory multiple myeloma (...
TIM3-Galectin9 axis drives CSF-1R–independent senescent macrophage and TSCM crosstalk in chronic graft-versus-host disease
Abstract Background: Chronic graft-versus-host disease (cGVHD) remains a major cause of morbidity post-allogeneic hematopoietic cell transpla...
Prevalence of iron deficiency in pregnant women with inherited bleeding disorders: A retrospective analysis
Abstract Introduction: Women with an inherited bleeding disorder (IBD) are at an increased risk of developing iron deficiency with or withou...
First-line consolidation with cemacabtagene ansegedleucel (cema-cel) in patients with large B-cell lymphoma (LBCL) and minimal residual disease (MRD) after response to standard therapy: The pivotal, randomized, open‑label Phase 2 ALPHA3 study
Abstract Background and Significance: R-CHOP as first-line (1L) therapy for LBCL has a cure rate of ~60%. However, ~10% of patients (pts) hav...
Treatment with acalabrutinib in IGHV mutated setting and presence of splenomegaly are the main predictors of faster lymphocyte count decrease in CLL during monotherapy with cbtki
Abstract BACKGROUND Covalent Bruton's tyrosine kinase inhibitors (cBTKi) have revolutionized the treatment of Chronic Lymphocytic Leukemia (...
Finding ferritin footprints in 5-fluorouracil-induced cardiotoxicity
Abstract Introduction Fluoropyrimidines including 5-fluorouracil (5-FU) are used in the treatment of patients with gastrointestinal malignan...
The bispecific blind spot: Uncovering real-world inequities in diffuse large B-cell lymphoma, follicular lymphoma, and multiple myeloma therapy access
Abstract Introduction: Bispecific antibodies (BsAbs) and CAR T-cell therapy (CAR T) represent significant advancements in hematologic malign...
IgG2a-formatted 4-1BB agonism combined with S100A9 inhibition enhances T cell activation and tumor control in a preclinical model of multiple myeloma
Abstract Introduction Immunotherapy has shown clinical promise in multiple myeloma (MM), but relapse remains common, largely due to the immu...
CELF2-deficient mutations promote B-cell lymphoma development by inducing a germinal center B-cell fate
Abstract RNA-binding proteins (RBPs) are key regulators in the processes of RNA transcription and translation. As an important member of RBP...
Treatment intensity and transplant independently predict survival in TP53-mutated myeloid neoplasms: A large retrospective cohort study of clinical and genomic factors
Abstract Introduction: Mutations in TP53 are recurrent in myeloid neoplasms and are often associated with complex cytogenetics, therapy-rela...
Toxicity profile of epcoritamab and glofitamab in aggressive B-cell lymphoma: A real-world analysis of CRS and icans in a single-center cohort
Abstract Background: Cytokine-release syndrome (CRS) and immune-effector-cell–associated neurotoxicity syndrome (ICANS) remain the principal...
A novel multi-target NGS application for molecular monitoring of measurable residual disease in Acute Myeloid Leukemia
Abstract Background . Measurable residual disease (MRD) in Acute Myeloid Leukemia (AML) is a prognostic indicator used in clinical practice f...