Blood
Articles in this Issue
Academic advantage without survival benefit? a national cancer database analysis of primary effusion lymphoma
Abstract Background: Primary effusion lymphoma (PEL) is a rare and aggressive HHV8-associated B-cell lymphoma that typically presents as mal...
Incidence of cardiac-related deaths among patients aged ≥65 years with B-cell malignancies treated with ibrutinib
Abstract Background Ibrutinib (ibr) is associated with an increased risk of fatal and serious cardiac failure in clinical trials, likely due...
Efficacy and safety of azacitidine plus LDAC in newly diagnosed, frail elderly patients with Acute Myeloid Leukemia
Abstract Effective treatment options remain limited for elderly patients with acute myeloid leukemia (AML) , particularly for those with sig...
Eculizumab vs control therapies in paroxysmal nocturnal hemoglobinuria: A meta-analysis of six randomized trials
Abstract Introduction: Eculizumab, a terminal complement C5 inhibitor, has significantly changed the treatment paradigm for paroxysmal noctu...
Early peripheral blood blast clearance is a prognostic marker for early treatment response and long-term outcome in pediatric Acute Myeloid Leukemia
Abstract Background: Bone marrow (BM) aspirates during and after induction chemotherapy are established but cumbersome prognostic tools for...
Rising mortality from Acute Myeloid Leukemia attributable to tobacco use in the United States, 1999–2020: A CDC wonder analysis
Abstract Background: Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with multifactorial etiology, in which environment...
Qualitative assessment of predictors of response to immunosuppressive therapy in aplastic anemia: A systematic literature review
Abstract Introduction Aplastic anemia (AA) is a rare hematologic disorder. Recommended treatments include hematopoietic...
Golidocitinib combined with CHOP in newly-diagnosed peripheral T-cell lymphoma: Preliminary Results from A phase 1/2 clinical trial
Abstract Background： Peripheral T-cell lymphoma (PTCL) comprises a group of heterogeneous and aggressive non-Hodgkin lymphomas associated w...
WU-CART-007, a CD7-directed allogeneic CAR-T cell therapy for R/R T-cell acute lymphoblastic leukemia/lymphoma: Phase 1/2 correlative data and long-term follow-up update
Abstract Background: WU-CART-007 (WU-007), an allogeneic CD7-targeted CAR-T cell therapy, is under evaluation for relapsed/refractory T-cell...
Anti-CD94 monoclonal antibody DR-01 induced response in a refractory primary CNS T-cell lymphoma
Abstract Primary central nervous system (CNS) lymphoma is an extranodal non-Hodgkin lymphoma affecting the brain, spine, cerebrospinal fluid...
Analysis of the role of baseline PET/CT in a prospective study of unselected patients: The UK MCL biobank
Abstract Introduction: Mantle cell lymphoma (MCL) comprises 5-6% of NHL and has heterogenous clinical outcomes. There is...
Differences in insurer payments for hematology part B drugs between traditional Medicare and Medicare advantage
Abstract Background: Many medications administered to Medicare patients with hematological conditions are Part B drugs, including monoclonal...
Lentiviral hematopoietic stem and progenitor cell gene therapy for Wiskott-Aldrich Syndrome: Early access experience in Italian patients based on 648/1996 law
Abstract Background Wiskott-Aldrich Syndrome (WAS) is a rare, X-linked immunodeficiency, also characterized by microthrombocytopenia, eczema...
PET imaging biomarkers predict survival in peripheral T-cell lymphoma: A systematic review and meta-analysis.
Abstract Background Peripheral T-cell lymphomas (PTCLs) are aggressive and heterogeneous lymphoid malignancies with poor prognoses and limit...
Chronic opioid medication use is associated with healthcare utilization and fatigue in adults with sickle cell disease
Abstract Background Chronic sickle cell pain is linked to poorer quality of life, depressive symptoms, anxiety, and slee...
High concentrations of 17β-estradiol suppress CORO7 and impair megakaryocyte proplatelet formation in individuals with immune thrombocytopenia during pregnancy
Abstract Introduction Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by isolated thrombocytopenia. ITP during pregnan...
Delayed and sustained minimal residual disease response predictsfavorable outcomes in newly diagnosed multiple myeloma
Abstract Minimal residual disease (MRD) negativity is a well-established prognostic marker in multiple myeloma (MM), yet the clinical releva...
Proof of concept and mechanistic evaluation of lbl-034, a potent GPRC5D-targeting T cell engager with affinity-optimized, sterically engineered anti-CD3 arm, in a multiple myeloma xenograft mouse model
Abstract Introduction T-cell mediated therapies have demonstrated promising efficacy in multiple myeloma (MM), exemplified by the recent US...
Machine learning uncovers invariant evolutionary molecular trajectories in MDS.
Abstract Distinct molecular underpinnings in diverse cases of MDS may result in similar prognosis and therefore outcome-supervised prognosti...
Preliminary results from a phase 1/1b first-in-human study of BGB-21447, a next-generation BCL2 inhibitor, in patients with B-cell non-Hodgkin lymphoma
Abstract Introduction: B-cell lymphoma 2 (BCL2)–mediated resistance to the intrinsic apoptosis pathway is a key factor in the pathogenesis a...
Immunotherapy resistant ALL cells exhibit selective dependence on glutamine and specific transporters for growth and survival
Abstract Introduction: Acute lymphoblastic leukemia (ALL) needs newer therapeutic options, especially in patients that fail targeted immunot...
Mothers of children with fetal/neonatal alloimmune thrombocytopenia (FNAIT) develop significant psychological distress
Abstract Background: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare maternal-fetal disorder, resulting from parental plate...
Robust assessment of early MRD levels could further improve treatment outcomes in low-risk patients of pediatric acute lymphoblastic leukemia: The Report of Taiwan Pediatric Oncology Group (TPOG)-ALL Study
Abstract Treatment modification, including but not limited to deintensifcation, for pediatric acute lymphoblastic leukemia (ALL) without com...
Sparse whole genome sequencing and machine learning of AML genomes reveals novel, clinically relevant genetics.
Abstract Copy Number Alterations (CNAs), including chromosomal gains and losses, shape the genetics and clinical management of acute myeloid...
ALTseqTM, a rapid (< 48 hours) whole genome sequencing clinical test for Acute Myeloid Leukemia (AML)
Abstract AML accounts for one-third of adult leukemias. With an incidence of approximately 22, 000 new cases/year, AML is projected to cause...