Blood
Articles in this Issue
Area deprivation index as a predictor of survival and treatment disparities in older adults with Acute Myeloid Leukemia: A population-based Study
Abstract Introduction: Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with poor prognosis, particularly in older adult...
Dermatologic toxicities associated with talquetamab in patients with Relapsed/Refractory multiple myeloma: A systematic review and meta-analysis
Abstract Introduction Multiple myeloma (MM) is an incurable malignancy, and the management of relapsed/refractory (RR) c...
Hydroxyurea sequesters the histone methyltransferase G9a at stressed replication forks to reactivate fetal hemoglobin
Abstract Perturbations to S phase that lead to replication stress can induce clinically relevant changes in cell state, such as differentiat...
Optimal trispecific CAR construct simultaneously targets BCMA, GPRC5D, and CD38 to treat antigen-heterogeneous multiple myeloma
Abstract Introduction: BCMA, GPRC5D, and CD38 are highly and independently expressed on malignant plasma cells in relapsed/refractory multip...
Synthetic oligonucleotides contain synthesis errors that are propagated into the genome by editing through homology-directed repair
Abstract Single-stranded oligonucleotides (ssODNs) serve as donor templates for gene editing through targeted endonuclease cleavage and homo...
CD19 CAR-T cell therapy in AML1-ETO positive Acute Myeloid Leukemia: A multi-omics analysis of response determinants
Abstract Background: CD19-directed CAR-T therapy has demonstrated remarkable clinical efficacy in B-cell malignancies, leading to multiple F...
Therapy-related AML (t-AML) on the rise: A national perspective on evolving trends, treatment outcomes, and prognostic implications in hospitalized patients
Abstract Introduction: Therapy-related Acute Myeloid Leukemia (t-AML) is defined as a type of Acute Myeloid Leukemia (AML) that arises from...
Intravital imaging of the spatiotemporal dynamics of fibrinolysis in a murine model of vascular injury
Abstract Fibrinolysis plays a key role in maintaining hemostatic balance by removing unnecessary or excessive thrombi, thereby maintaining v...
Physicians perceptions of fixed-duration epcoritamab + lenalidomide and rituximab regimens in relapsed/refractory follicular lymphoma: Insights from the epcore NHL-2 trial
Abstract Introduction: Follicular lymphoma (FL) is an indolent, yet incurable subtype of non-Hodgkin lymphoma characterized by frequent rela...
Response to Hetrombopag Among patients with acute and persistent primary immune thrombocytopenia: A real-world study in China
Abstract Background: Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by low platelet counts (PC), which increases the...
Identification of red cell distribution width as a key predictor of leukemic transformation in polycythemia vera and essential thrombocythemia: A machine learning approach involving 10,560 cases
Abstract Background Red blood cell distribution width (RDW) is an easily accessible diagnostic test that is underutilized as a prognostic ma...
High expression of GFP on hematopoietic stem cells acts as a neoantigen triggering increased T cell-mediated clearance and reduced self-renewal
Abstract Murine transplantation studies are the gold standard to assess functional potential of normal and malignant hematopoietic stem cell...
Safety and effectiveness of brentuximab vedotin in Chinese adult patients with classical Hodgkin's lymphoma: Results from a multicenter, prospective, observational, real-world study
Abstract Introduction: Brentuximab vedotin (BV), a CD30-specific antibody-drug conjugate (ADC), is approved for the treatment of previously...
HLA mismatch-derived epitopes predict acute graft-versus-host disease risk after unrelated donor transplantation
Abstract Background: Complete and precise HLA matching of unrelated donors reduces the risk of complications following allogeneic hematopoie...
Downregulation of midnolin mediating non-ubiquitin protein degradation and its role in myelomagenesis.
Abstract To identify novel tumor suppressor genes that play critical roles in controlling myeloma cell proliferation and survival, we perfor...
Immune tolerance induction after haploidentical stem cell transplant following organ transplantation in sickle cell disease
Abstract Background: Sickle cell disease (SCD) is debilitating inherited hemoglobinopathy leading to progressive, age-dependent multi-organ...
LSD1 inhibition enhances venetoclax efficacy in Acute Myeloid Leukemia via metabolic rewiring
Abstract Introduction: Acute myeloid leukemia (AML) is an aggressive hematological malignancy with poor outcomes. Venetoclax, a BCL2 inhibito...
Dnmt3a-mutant hematopoietic stem cells generate alloreactive T cells with graft vs host disease and graft vs leukemia effects
Abstract Clonal hematopoiesis (CH) is an age-related phenomenon caused by expansion of a hematopoietic stem cell (HSC) clone with an acquire...
Characterization and risk factors of anticoagulation-related bleeding in patients with thrombotic antiphospholipid syndrome: An analysis using a synthetic real-world data platform
Abstract Introduction: Antiphospholipid Syndrome (APS) is a systemic autoimmune condition associated with an elevated risk of both arterial...
ASC4OPT 96-week results: Asciminib once or twice daily continues to be highly efficacious and demonstrates favorable safety in patients with chronic myeloid leukemia and suboptimal response, resistance or intolerance to two or more tyrosine kinase inhibitors
Abstract Introduction: The primary results of the ASC4OPT study (NCT04948333), assessing asciminib 40 mg twice daily (BID) and 80 mg once da...
Front-line consolidation with CAR-t therapy in newly diagnosed adult ph-negative b-acute lymphoblastic leukemia: Results from a prospective, phase 2 study
Abstract Background: Achieving deep remission is crucial for durable responses in B-cell acute lymphoblastic leukemia (B-ALL). Our group has...
Ibrutinib plus blinatumomab in Relapsed/Refractory B-cell acute lymphoblastic leukemia: Results of A phase 2 study
Abstract Background: Blinatumomab (BLIN), a CD19xCD3 bispecific T-cell engager, improves outcomes in relapsed/refractory B-cell acute lymphob...
Venetoclax plus hypomethylating agent as first- and second-line treatment in patients with AML: A single-center experience
Abstract Venetoclax combined with a hypomethylating agent is the standard of care for patients with newly diagnosed acute myeloid leukemia (...
Pacritinib in transplant-eligible myelofibrosis: Final analysis of the phase 2 HOVON-134 trial
Abstract Introduction: Current EBMT/ELN-guidelines recommend pre-transplant spleen-directed management with JAK-inhibitors in symptomatic my...
First-line treatment with low-dose ruxolitinib, pirfenidone, and low-dose calcineurin inhibitors leads to significant improvement in patients with bronchiolitis obliterans syndrome after allogeneic transplantation
Abstract Introduction Bronchiolitis obliterans syndrome ( BOS ) is a clinical syndrome characterized by new-onset persistent airflow limitat...